Cancer Signaling and Pathways

Signaling pathways control cell functions including cell division and cell death. Abnormal activation of these signaling pathways may lead to diseases such as cancer. For example, mutations in the genes that encode Ras proteins, a family of growth-promoting enzymes, can send cells’ growth-signaling pathways into overdrive and are thought to fuel more than 30 percent of human cancers. CCR researchers are studying cancer signaling pathways to understand precisely how they are activated with the goal of developing new, targeted cancer treatments to disrupt these pathways. We invite you to meet some of our principal investigators conducting research in this area.