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Jing  Huang, Ph.D.

Jing Huang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Huang has extensive experience in transcriptional and epigenetic regulation in stem cells and cancer. His earlier work has contributed to resolving a long-standing controversy over the role of p53 in embryonic stem cells and embryonic development. His current research is focused on embryonic stem cells and mesenchymal stem cells. He mainly studies osteosarcoma and breast cancer. Dr. Huang hopes to gain insights from his studies that may contribute to novel therapies for both stem cell diseases and cancer. To achieve these goals, Dr. Huang’s team employs biochemical, molecular, epigenetic, and genomic approaches as well as mouse models.

Areas of Expertise

Embryonic and Mesenchymal Stem Cells
p53
Epigenetics

Publications

Selected Key Publications

CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer

Malik N, Yan H, Yang HH, Ayaz G, DuBois W, Tseng YC, Kim YI, Jiang S, Liu C, Lee M, Huang J
PLOS Genetics. 12(2): e1009553, 2021.
Full-Text Article
[ Journal Article ]

Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress

Yan H, Malik N, Kim YI, He Y, Li M, Dubois W, Liu H, Peat TJ, Nguyen JT, Tseng YC, Ayaz G, Alzamzami W, Chan K, Andresson T, Tessarollo L, Mock BA, Lee MP, Huang J
EMBO Reports. 22(6): e52122, 2021.
Full-Text Article
[ Journal Article ]

The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J
Nature Communications. 2019. [ Journal Article ]

An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

Li M, Gou H, Tripathi BK, Huang J, Jiang S, Dubois W, Waybright T, Lei M, Shi J, Zhou M, Huang J
Cell Stem Cell. 16(6): 669-683, 2015. [ Journal Article ]

Distinct regulatory mechanisms and functions of p53-activated and p53-repressed DNA damage response genes in embryonic stem cells

Li M, He Y, Dubois W, Wu X, Shi J, Huang J.
Mol Cell. 46: 30-42, 2012. [ Journal Article ]

Job Vacancies

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Team

Research Biologist
Shunlin Jiang, M.D.
Postdoctoral Fellow (Visiting)
Hualong Yan, Ph.D.
Postdoctoral Fellow (Visiting)
Sasha Wang, M.D.

News

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