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Jing  Huang, Ph.D.

Jing Huang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Huang has extensive experience in transcriptional and epigenetic regulation in stem cells and cancer. His earlier work has contributed to resolving a long-standing controversy over the role of p53 in embryonic stem cells and embryonic development. His current research is focused on embryonic stem cells and mesenchymal stem cells. He mainly studies osteosarcoma and breast cancer. Dr. Huang hopes to gain insights from his studies that may contribute to novel therapies for both stem cell diseases and cancer. To achieve these goals, Dr. Huang’s team employs biochemical, molecular, epigenetic, and genomic approaches as well as mouse models.

Areas of Expertise

1) embryonic stem cells 2) mesenchymal stem cells 3) p53 4) epigenetics 5) genomics 6) sarcoma

Publications

Selected Key Publications

The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J
Nature Communications. 2019. [ Journal Article ]

cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma

He Y, Zhu W, Shin MH, Gary J, Liu C, Dubois W, Hoover SB, Jiang S, Marrogi E, Mock B, Simpson RM, Huang J.
Stem Cell Reports. 8(6): 1630-1644, 2017. [ Journal Article ]

A RUNX2-mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells

Min Hwa Shin, Yunlong He, Eryney Marrogi, Sajida Piperdi, Ling Ren, Chand Khanna, Richard Gorlick, Chengyu Liu, Jing Huang
PLOS Genetics. 12(2): e1005884, 2016. [ Journal Article ]

An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

Li M, Gou H, Tripathi BK, Huang J, Jiang S, Dubois W, Waybright T, Lei M, Shi J, Zhou M, Huang J
Cell Stem Cell. 16(6): 669-683, 2015. [ Journal Article ]

Distinct regulatory mechanisms and functions of p53-activated and p53-repressed DNA damage response genes in embryonic stem cells

Li M, He Y, Dubois W, Wu X, Shi J, Huang J.
Mol Cell. 46: 30-42, 2012. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - RUNX proteins, breast cancer, osteosarcoma Ph.D. or equivalent, M.D. or equivalent Jing Huang huangj3@mail.nih.gov
Post-doctoral Fellow - Gene expression, epigenetics, tumor organoids Ph.D. or equivalent Jing Huang huangj3@mail.nih.gov

Team

Predoctoral Fellow (Graduate Student)
Waseem Abdulmannan Alzamzami
Research Biologist
Shunlin Jiang, M.D.
Staff Scientist
Navdeep Malik, Ph.D.
Postdoctoral Fellow (Visiting)
Yu-Chou Tseng, Ph.D.
Postdoctoral Fellow (Visiting)
Hualong Yan, Ph.D.