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Jing  Huang, Ph.D.

Jing Huang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Head, Cancer and Stem Cell Epigenetics Section

RESEARCH SUMMARY

Dr. Huang’s group explores transcriptional and epigenetic regulation in stem cells and cancer. His earlier research focused on understanding the role of p53 in embryonic stem cells and embryonic development. Currently, the team is dedicated to identifying and targeting transcriptional and epigenetic vulnerabilities in osteosarcoma and breast cancer, aiming to develop innovative therapeutic strategies. To achieve this objective, Dr. Huang's team investigates the functions of several transcription factors (p53, CBFB, and RUNXs) and employs various approaches, including molecular, biochemical, epigenetic, and genomic techniques, as well as utilizing mouse models and human samples.

Areas of Expertise

Publications

Selected Recent Publications

Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

Navdeep Malik , Young-Im Kim , Hualong Yan , Yu-Chou Tseng , Wendy du Bois , Gamze Ayaz , Andy D Tran , Laura Vera Ramírez , Howard H Yang , Aleksandra M Michalowski , Michael Kruhlak , Maxwell Lee , Kent W Hunter , Jing Huang
Cancer Research. 2023. [ Journal Article ]

CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer

Malik N, Yan H, Yang HH, Ayaz G, DuBois W, Tseng YC, Kim YI, Jiang S, Liu C, Lee M, Huang J
PLOS Genetics. 12(2): e1009553, 2021.
Full-Text Article
[ Journal Article ]

Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress

Yan H, Malik N, Kim YI, He Y, Li M, Dubois W, Liu H, Peat TJ, Nguyen JT, Tseng YC, Ayaz G, Alzamzami W, Chan K, Andresson T, Tessarollo L, Mock BA, Lee MP, Huang J
EMBO Reports. 22(6): e52122, 2021.
Full-Text Article
[ Journal Article ]

The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J
Nature Communications. 2019. [ Journal Article ]

An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

Li M, Gou H, Tripathi BK, Huang J, Jiang S, Dubois W, Waybright T, Lei M, Shi J, Zhou M, Huang J
Cell Stem Cell. 16(6): 669-683, 2015. [ Journal Article ]

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