Jing  Huang, Ph.D.

Jing Huang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Huang's research expertise lies in studying transcriptional and epigenetic regulation in both stem cells and cancer. His previous work as an independent investigator has been studying the role of p53 in embryonic stem cells and embryonic development. His current primary effort is identifying and targeting transcriptional and epigenetic vulnerabilities in osteosarcoma and breast cancer, aiming to develop new therapeutic strategies for these diseases. To achieve this goal, Dr. Huang's team focuses on several transcription factors (p53, CBFB, and RUNXs) and utilizes a variety of approaches, including molecular, biochemical, epigenetic, and genomic techniques, as well as mouse models and human samples.

Areas of Expertise

Embryonic and Mesenchymal Stem Cells


Selected Recent Publications

Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

Navdeep Malik , Young-Im Kim , Hualong Yan , Yu-Chou Tseng , Wendy du Bois , Gamze Ayaz , Andy D Tran , Laura Vera Ramírez , Howard H Yang , Aleksandra M Michalowski , Michael Kruhlak , Maxwell Lee , Kent W Hunter , Jing Huang
Cancer Research. 2023. [ Journal Article ]

CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer

Malik N, Yan H, Yang HH, Ayaz G, DuBois W, Tseng YC, Kim YI, Jiang S, Liu C, Lee M, Huang J
PLOS Genetics. 12(2): e1009553, 2021.
Full-Text Article
[ Journal Article ]

Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress

Yan H, Malik N, Kim YI, He Y, Li M, Dubois W, Liu H, Peat TJ, Nguyen JT, Tseng YC, Ayaz G, Alzamzami W, Chan K, Andresson T, Tessarollo L, Mock BA, Lee MP, Huang J
EMBO Reports. 22(6): e52122, 2021.
Full-Text Article
[ Journal Article ]

The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J
Nature Communications. 2019. [ Journal Article ]

An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells

Li M, Gou H, Tripathi BK, Huang J, Jiang S, Dubois W, Waybright T, Lei M, Shi J, Zhou M, Huang J
Cell Stem Cell. 16(6): 669-683, 2015. [ Journal Article ]

Job Vacancies

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Congratulations to Hualong, who won an Outstanding Oral Presentation Award for his study of epigenetic regulation and therapeutic strategy of osteosarcoma!

Hualong and Young-Im are selected by the 2023 CCR-FYI Colloquium to give an oral presentation. Congratulations to both! 

Payel joined the team. Welcome!

Hualong received a 2023 FARE award. Congratulations!

Young-Im received a 2022 FARE award. Congratulations!