Search all CCR Clinical Trials
Below is a list of all open NCI Center for Cancer Research (CCR) clinical trials, including studies that are currently recruiting patients (i.e. Open - Recruiting) as well as trials that will be recruiting soon (i.e., Open - Not yet Recruiting). Most recently opened trials are listed first.
All CCR clinical trials take place at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland.
Clinical trials at the NIH Clinical Center are open to patients with cancer, HIV, or immunodeficiency disorders, regardless of where they live in the United States.
-
A Phase I/II Study of Bintrafusp alfa (M7824) and M9241 in Combination with Docetaxel in Adults with Metastatic Castration Sensitive and Castration Resistant Prostate Cancer
Open - Not yet Recruiting Summary Not Yet Available. Call Referral Contact.NCI Protocol ID NCI-21-C-0001Investigator Ravi A. Madan, M.D. -
Understanding the Patient Experience: Symptom Burden in Pediatric Patients Receiving Chimeric Antigen Receptor (CAR) T-cell Therapy
Open - Recruiting Summary Not Yet Available. Call Referral Contact.NCI Protocol ID NCI-00-0-067Investigator Haneen Shalabi, D.O.Share this trial: Referral ContactsContact Name Phone Number NCI Pediatric Leukemia Lymphoma BMT Team (240)760-6970 -
Phase II Study of combination of Trametinib (MEK inhibitor) and Hydroxychloroquine (HCQ) (autophagy inhibitor) in Patients with KRAS Mutation Refractory Bile Tract Carcinoma (BTC).
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0152Investigator Tim F. Greten, M.D. -
A Phase 1 Study of Venetoclax with Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies#xD;
Open - Not yet Recruiting Summary Not Yet Available. Call Referral Contact.NCI Protocol ID NCI-20-C-0162Investigator Mark Roschewski, M.D. -
Prospective Study of Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0161Investigator Andrew M. Blakely, M.D.Share this trial: Referral ContactsContact Name Phone Number Cathleen Hannah 240-409-8860 NIH Foregut team 240-858-3610 -
A phase 1/2, open label, dose-escalation, safety and tolerability study of NC410 in subjects with advanced or metastatic solid tumors
Open - RecruitingNCI Protocol ID NCI-20-C-0098Investigator Marijo Bilusic, M.D., Ph.D. -
Phase I/II trial investigating the safety, tolerability, pharmacokinetics, immune and clinical activity of SX-682 in combination with TriAdeno vaccine regimen and M7824 (TGF-b “trap”/PD-L1; Bintrafusp alpha) in advanced solid tumors (STAT).
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0155Investigator James L. Gulley, M.D., Ph.D. -
Phase II Trial of Olaparib (LYNPARZA) plus Durvalumab (IMFINZI) in EGFR-Mutated Adenocarcinomas that Transform to Small Cell Lung Cancer (SCLC) and Other Neuroendocrine Tumors.
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0149Investigator Anish Thomas, MBBS, M.D. -
Phase II Randomized Trial of Bethesda Protocol compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0150Investigator Jeremy L. Davis, M.D. -
Phase II Trial of Combination Immunotherapy in Subjects with Advanced Small Bowel and Colorectal Cancers
Open - RecruitingNCI Protocol ID NCI-20-C-0138Investigator Julius Strauss, M.D. -
A Phase II Study of Bintrafusp alfa (M7824) in Checkpoint Inhibitor Naïve and Refractory Subjects with Urothelial Carcinoma
Open - RecruitingNCI Protocol ID NCI-20-C-0142Investigator Andrea B. Apolo, M.D. -
A first-in-human phase I single-agent dose-escalation, food effect and dose expansion study of oral ONC206 in recurrent and rare primary central nervous system neoplasms
Open - Recruiting Summary Not Yet Available. Call Referral Contact.NCI Protocol ID NCI-20-C-0069Investigator Mark R. Gilbert, M.D. -
A Pilot Study of E7 TCR T Cell Induction Immunotherapy for Stage IIB-IVA Cervical Cancer
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0116Investigator Christian S. Hinrichs, M.D. -
Natural History Study of Children and Adults with Neuroendocrine Neoplasms (NENs)
Open - RecruitingNCI Protocol ID NCI-20-C-0139Investigator Jaydira Del Rivero, M.D. -
A Phase 1 Study of Romidepsin, CC-486 (5-azacitidine), Dexamethasone, and Lenalidomide (RAdR) for Relapsed/refractory T-cell Malignancies
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0127Investigator Milos Miljković, M.D., M.Sc. -
Natural History Study of Children and Adults with Adrenocortical Cancer
Open - RecruitingNCI Protocol ID NCI-20-C-0110Investigator Jaydira Del Rivero, M.D. -
Prospective Evaluation of High Resolution Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients with BAP1 Tumor Predisposition Syndrome#xD;
Open - Not yet RecruitingNCI Protocol ID NCI-20-C-0106Investigator David S. Schrump, M.D., M.B.A. -
Phase I/II Trial of HPV Vaccine PRGN-2009 Alone or in Combination with Anti-PD-L1/TGF-ß trap (M7824) in Subjects with HPV Positive Cancers
Open - RecruitingNCI Protocol ID NCI-20-C-0104Investigator Julius Strauss, M.D.Share this trial: Referral ContactsContact Name Phone Number -
A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects with Thymoma and Thymic Carcinoma
Open - RecruitingNCI Protocol ID NCI-20-C-0097Investigator Arun Rajan, M.D.Share this trial: Referral ContactsContact Name Phone Number -
Investigation of the B- and T-cell repertoire and immune response in patients with acute and resolved COVID-19 infection
Open - RecruitingNCI Protocol ID NCI-20-C-0103Investigator Robert J. Kreitman, M.D.