Christopher J. Melani, M.D.

Christopher J. Melani, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Lymphoid Malignancies Branch


Dr. Melani is a Staff Clinician and a clinical researcher specializing in lymphoma. His areas of interest include the use of novel therapies and drug combinations for the treatment of lymphomas as well as novel methods of molecular monitoring of disease and response to treatment, such as circulating tumor DNA (ctDNA).

Areas of Expertise

Clinical Trials
Novel Drug Use

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.


Selected Recent Publications

PD-1 Blockade in Mediastinal Gray-Zone Lymphoma

Melani C, Major A, Schowinsky J, Roschewski M, Pittaluga S, Jaffe ES, Pack SD, Abdullaev Z, Ahlman MA, Kwak JJ, Morgan R, Rabinovitch R, Pan Z, Haverkos BM, Gutman JA, Pollyea DA, Smith CA, Wilson WH, Kamdar M.
New Engl J Med. 377(1): 89-91, 2017. [ Journal Article ]

DA-EPOCH-R in Primary Mediastinal B-Cell Lymphoma; Analysis of End of Therapy FDG-PET and Outcome

Melani CJ, Advani R, Chen CC, Walters KM, Venzon D, Steinberg SM, Shovlin M, Jaffe ES, Pittaluga S, Roschewski M, Wilson WH, Dunleavy K.
Blood. in press, 2017. [ Journal Article ]

Molecular Monitoring of Cell-Free Circulating Tumor DNA in Non-Hodgkin Lymphoma

Melani C, Roschewski M.
Oncology (Williston Park, NY). 30(8): 731-8, 2016. [ Journal Article ]

Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma

Lionakis MS, Dunleavy K, Roschewski M, Widemann BC, Butman JA, Schmitz R, Yang Y, Cole DE, Melani C, Higham CS, Desai JV, Ceribelli M, Chen L, Thomas CJ, Little RF, Gea-Banacloche J, Bhaumik S, Stetler-Stevenson M, Pittaluga S, Jaffe ES, Heiss J, Lucas N, Steinberg SM, Staudt LM, Wilson WH.
Cancer Cell. 31(6): 833-843, 2017. [ Journal Article ]

MYC gene rearrangement in diffuse large B-cell lymphoma does not confer a worse prognosis following dose-adjusted EPOCH-R

Lai C, Roschewski M, Melani C, Pittaluga S, Shovlin M, Steinberg SM, Dunleavy K, Pack S, Jaffe ES, Wilson WH.
Leuk Lymphoma. 22: 1-4, 2017. [ Journal Article ]