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Our Discoveries

Fluorescent image showing the protein CSF-1R (green), microglia (red), and cell nuclei (blue) in a breast cancer brain metastasis model. Microglia cells near and inside the brain tumors are expressing the CSF-1R protein (yellow)

New Strategy Shows Promise Against Deadly Breast Cancer in the Brain

A new NIH study points to a promising strategy for treating aggressive breast cancer that spreads to the brain, a complication with few effective options. Learn how blocking a key brain cell survival pathway could open the door to future therapies.

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Immunofluorescence image of the cell adhesion protein basigin (turquoise) in TuNEPs released from dying 4T1 mouse breast cancer cells.

Proteins Released from the Nuclei of Dying Cancer Cells Promote Tumor Growth

Material released from dying cancer cells, known as tumor cell nuclear expulsion products (TuNEPs), contains specific proteins that promote the growth of neighboring cancer cells. Targeting these proteins could lead to new treatments that hinder cancer spread and improve patient outcomes.

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An illustration of papillomas in the throat

CCR Research Leads to FDA Approval of First Immunotherapy for Recurrent Respiratory Papillomatosis

The U.S. Food and Drug Administration has granted full market approval for Papzimeos (zopapogene imadenovec-drba), a groundbreaking non-replicating adenoviral vector-based immunotherapy designed for adult patients with recurrent respiratory papillomatosis (RRP).

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a small cluster of cancer cells that has spread from the primary tumor

Protein makes cancer cells easier to destroy with immunotherapy

A protein called GCN1 can trigger a stress response inside cancer cells and simultaneously help them hide from the immune system. Research found these processes can be blocked by another protein called IMPACT, which could enhance immunotherapy’s ability to find and kill cancer cells.

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Spatial heatmap of CD3+ T cells in small cell lung cancer (SCLC) tumors. Top: Notch1 gene inactive, “cold” SCLC with T cells located on the tumor periphery (immune-excluded). Bottom: Notch1 gene active, “hot” SCLC with abundant T cell tumor infiltration (immune-inflamed).

Activated gene elicits robust immune response in lung cancer

The activation of NOTCH1, a gene known to control cell differentiation and growth, stimulates a robust immune response in small cell lung cancer. Expression of this gene can also predict survival with immunotherapy.

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Cells showing the biosensor used in this study to test the activity of APC/C

Study uncovers new details on pulsing enzyme activity during cell cycle

Enzymatic activity during the start of the cell cycle could be harnessed to inhibit cancer cell reproduction.

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An illustration of immune cells with zeroes and ones, representing CIDE, a new, large-scale immuno-oncology data platform.

Cancer Immunology Data Engine uncovers secreted proteins with therapeutic potential

CCR researchers have developed a new tool that identifies secreted proteins associated with immunotherapy outcomes.

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Graphic depiction of near-infrared photoimmunotherapy (NIR-PIT) targeted against ICAM-1 markers (small, blue, Y-shaped), causing cancer cell death and suppressed tumor growth (pink cluster, center).

CCR-developed cancer therapy shrinks tumors and boosts immune response

A targeted cancer therapy developed at CCR shows promise in its ability to target a common cancer cell marker, both shrinking tumors and producing a boosted immune response.

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A graphic depiction of the dimethoxyphenyl cyanoacrylamide (DiMe) chemical warhead facilitating reversible binding of drug to its molecular target.

Synthesized chemical component helps cancer drugs remain stable in water

Researchers developed a new chemical component that can be attached to drug molecules to make them more stable in water without losing effectiveness. This innovation could improve the performance of some cancer treatments.

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Micrograph of renal cell carcinoma.

Combining bevacizumab with erlotinib shrinks tumors in patients with rare and aggressive kidney cancer

Seventy-two percent of patients with HLRCC-associated kidney cancers, for which there previously was no known drug treatment, responded to the therapy in a clinical trial.

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