CCR News: Our Discoveries

cross-section of a cell nucleus

Advanced imaging technology reveals pulsed hormone release regulates gene transcription

Sep 19, 2019

Using advanced microscopic imaging technology, CCR investigators have correlated a pulsed pattern of hormone release with bursts of transcription, the process in which the genetic information encoded by DNA is written into RNA. They are the first researchers to observe this process at a gene-specific level. Read more...

3D structure of a melanoma cell

Tumor composition of melanoma indicates potential responses to immunotherapy

Sep 13, 2019

The number of genetic mutations in a tumor is thought to influence how well melanoma may respond to immunotherapy, but new research in mice and supported by preliminary human data reveals that the diversity of mutations within a tumor may be a better indicator of response to therapy. Read more...

Chart on how CAR T-cell therapy works

FDA grants breakthrough therapy designation for new CAR T-cell therapy for B-cell acute lymphoblastic leukemia

Sep 10, 2019

In August 2019, the U.S. Food and Drug Administration granted breakthrough therapy designation to an experimental immunotherapy being developed in the Center for Cancer Research (CCR) for the treatment of B-cell acute lymphoblastic leukemia (ALL), a type of blood cancer. The designation will advance CCR’s development and testing of an immunotherapy for children and young adults whose B-cell ALL is resistant to CD19-targeted immunotherapies.  Read more...

Contour maps created from glucose and lactate signals

Researchers develop a new imaging technique to measure cancer metabolism

Sep 3, 2019

CCR researchers have developed a new technique to show metabolism from MRI images by reducing the amount of noise in those images, resulting in significantly improved quality. This breakthrough enables researchers to see biochemical processes, paving the way for a deeper understanding of tumors and potentially improved diagnosis and treatment. Read more...

Human breast tumor cells arrested in the blood vessels of zebrafish larvae

Tumor cells in transparent fish reveal physical and molecular factors that determine metastasis sites

Aug 21, 2019

CCR researchers used zebrafish to discover that particular sites colonized by migrating tumor cells are determined by both the physical architecture of tissue and the cells’ molecular compatibility with their microenvironment. Read more...

Cervical cancer cells

FDA grants breakthrough therapy designation of new TIL therapy for advanced cervical cancer

Aug 16, 2019

In May 2019, the FDA granted breakthrough therapy designation to a tumor-infiltrating lymphocyte (TIL) therapy technology known as LN-145 to treat advanced cervical cancer based on data presented by CCR collaborator Iovance Biotherapeutics.  Read more...

B cells imaged using super-resolution microscopy

In patients with severe chronic lymphocytic leukemia, B cells get stuck in hyperactive mode

Aug 5, 2019

Analyzing how cancer cells respond to stress signals could help clinicians assess the severity of disease in patients with chronic lymphocytic leukemia, according to new research from the Center for Cancer Research, Memorial Sloan Kettering Cancer Center and the National Heart, Lung and Blood Institute. Read more...

Human embryonic stem cells

New mechanism for regulating differentiation discovered in human embryonic stem cells

Jul 15, 2019

Researchers in the Center for Cancer Research have discovered a new mechanism involving a nuclease complex called the RNA exosome that represses differentiation of human embryonic stem cells. This represents the first time this mechanism has been studied in these cells. Read more...

RNA types

Gene-regulating microRNAs gain control over hundreds of new genes with common sequence modification

Jul 11, 2019

MicroRNAs have an enormous influence over what happens inside cells. By blocking the activity of specific sets of genes, they help control virtually every known biological pathway and process. Disruptions in microRNAs have been linked to many diseases, and understanding how these molecules function, which genes they control and how they themselves are regulated are high priorities in cancer research.  Read more...

T cells

Gastrointestinal tumors harbor T cells that recognize patients’ unique tumor antigens

Jun 25, 2019

CCR scientists, led by Steven A. Rosenberg, M.D., Ph.D., have determined that many common gastrointestinal tumors bear mutations capable of eliciting an immune response, suggesting that immunotherapy could be an effective way to treat these common cancers.  Read more...