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Stephanie L. Goff, M.D.

Stephanie L. Goff, M.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10 - Hatfield Clinical Research Center, Room 3-5930
  • Bethesda, MD 20892
  • 240-760-6214
  • stephanie.goff@nih.gov
Surgery Branch

RESEARCH SUMMARY

As a member of Dr. Rosenberg's senior staff, I share responsibility for the care and management of patients receiving cell-based immunotherapy for the treatment of metastatic solid tumors on protocols established by the Surgery Branch. These patients have a variety of malignancies (melanoma, ovarian, breast, gastrointestinal, sarcoma, etc.). My research is two-pronged: (1) focused on the use of adoptive cell transfer in patients with metastatic breast cancer, based on a system of identifying non-synonymous mutations within an individual tumor and evaluating the ability of that patient's lymphocytes to recognize the mutation in vitro and (2) further understanding therapeutic options for patients with treatment-refractory melanoma. 

Areas of Expertise

1) immunotherapy 2) melanoma 3) breast cancer 4) surgical oncology

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.

Clinical Trials

Publications

Selected Key Publications

Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma

Seitter SJ, Sherry RM, Yang JC, Robbins PF, Shindorf ML, Copeland AR, McGowan CT, Epstein M, Shelton TE, Langhan MM, Franco Z, Danforth DN, White DE, Rosenberg SA, Goff SL.
Clinical Cancer Research. 27/19: 5289-5298, 2021.
Full-Text Article
[ Journal Article ]

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Zacharakis N, Chinnasamy H, Black M, Xu H, Lu YC, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, Gartner J, Jia L, Trebska-McGowan K, Somerville RP, Robbins PF, Rosenberg SA, Goff SL, Feldman SA.
Nature Medicine. 24(6): 724-730, 2018. [ Journal Article ]

Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

Goff SL, Dudley ME, Citrin DE, Somerville RP, Wunderlich JR, Danforth DN, Zlott DA, Yang JC, Sherry RM, Kammula US, Klebanoff CA, Hughes MS, Restifo NP, Langhan MM, Shelton TE, Lu L, Kwong ML, Ilyas S, Klemen ND, Payabyab EC, Morton KE, Toomey MA, Steinberg SM, White DE, Rosenberg SA
J Clin Oncol. 2016 May 23. pii: JCO667220. [Epub ahead of print]: [ Journal Article ]

Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer

Assadipour Y, Zacharakis N, Crystal JS, Prickett TD, Gartner JJ, Somerville RPT, Xu H, Black MA, Jia L, Chinnasamy H, Kriley I, Lu L, Wunderlich JR, Zheng Z, Lu YC, Robbins PF, Rosenberg SA, Goff SL, Feldman SA
Clin Cancer Res. 2017. [ Journal Article ]

Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion

Goff SL, Johnson LA, Black MA, Xu H, Zheng Z, Cohen CJ, Morgan RA, Rosenberg SA, Feldman SA.
Cancer Immunol Immunother. 59: 1551-60, 2010. [ Journal Article ]