Stephanie L. Goff, M.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10 - Hatfield Clinical Research Center, Room 3-5930
- Bethesda, MD 20892
As a member of Dr. Rosenberg's senior staff, I share responsibility for the care and management of patients receiving cell-based immunotherapy for the treatment of metastatic solid tumors on protocols established by the Surgery Branch. These patients have a variety of malignancies (melanoma, ovarian, breast, gastrointestinal, sarcoma, etc.). My research is two-pronged: (1) focused on the use of adoptive cell transfer in patients with metastatic breast cancer, based on a system of identifying non-synonymous mutations within an individual tumor and evaluating the ability of that patient's lymphocytes to recognize the mutation in vitro and (2) further understanding therapeutic options for patients with treatment-refractory melanoma.
Areas of Expertise
1) immunotherapy 2) melanoma 3) breast cancer 4) surgical oncology
Information for Patients
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We are evaluating tumor-infiltrating lymphocytes in tumors removed from patients with metastatic breast cancer, developing methods to explore adoptive cell transfer for this patient population. In addition to genomic studies to evaluate non-synonymous mutations, we are also exploring the development of T-cell receptors for future opportunities to explore gene-engineered peripheral blood lymphocytes (PBL) for clinical use.
Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma
Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer
Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion
Stephanie L. Goff, M.D.
Stephanie Goff is a surgeon on the senior staff of the Surgery Branch of the National Cancer Institute at the NIH. Her research interests include adoptive cell therapy for the treatment of solid tumors, building on the backbone of success in patients with metastatic melanoma to investigate the strategy in patients with metastastic breast cancer. Her publications range from analysis of early trials of checkpoint blockade to genetic modifications of T-cell receptors.
She is an honors graduate of the Georgia Institute of Technology (Mechanical Engineering) and obtained her MD at the University of South Florida in Tampa. After training in tumor immunology under Dr. Steven Rosenberg, Dr. Goff completed her general surgery residency at Columbia University followed by a surgical oncology fellowship at the combined Dana-Farber Cancer Institute/Brigham and Women’s Hospital/Massachusetts General Hospital program.
Awards and Honors
2020 NIH Director's Award - The Alan S. Rabson Award for Clinical Care
2020 NIH Clinical Center - Staff Clinician of the Year
2019 NCI Director's Award of Merit