A Conversation with Bríd Ryan, Ph.D., M.P.H.

Bríd Ryan, Ph.D., M.P.H., is an NIH Stadtman Investigator in the Laboratory of Human Carcinogenesis at the Center for Cancer Research. Her research focuses on health disparities related to lung cancer across different populations. She discusses her latest research findings and future directions of her work as well as the importance of the supportive CCR environment in this Q&A. Read more...

Burkitt lymphoma

Study confirms effective, less toxic alternative to standard treatment for adults with Burkitt lymphoma

May 27, 2020

In a new study, an alternative treatment regimen that is less toxic than standard dose-intensive chemotherapy was found to be highly effective for adults with Burkitt lymphoma across all age groups and independent of HIV status. In addition to being better tolerated, the regimen, called dose-adjusted (DA) EPOCH-R, is already an option for diffuse large B-cell lymphomas and can be administered in an outpatient setting. The study was led by researchers in the Center for Cancer Research, and the DA-EPOCH-R regimen was originally developed by researchers led by Wyndham Wilson, M.D., Ph.D., Senior Investigator in the Lymphoid Malignancies BranchRead more...

Kaposi sarcoma

FDA approves pomalidomide for AIDS-related Kaposi sarcoma

May 15, 2020

On May 14, 2020, the Food and Drug Administration expanded the indication of pomalidomide (POMALYST, Celgene Corporation) to include treating adult patients with AIDS-related Kaposi sarcoma after failure of highly active antiretroviral therapy and Kaposi sarcoma in adult patients who are HIV-negative. This oral therapy is the first new treatment option available for those with Kaposi sarcoma in more than 20 years. Read more...

Stephen Oroszlan

In Memoriam: Stephen Oroszlan, Ph.D.

May 15, 2020

The Center for Cancer Research mourns the recent death of past colleague and friend Stephen Oroszlan. He was an esteemed member of the NCI community from 1976-1995 and served as a Scientist Emeritus since 1995.  Read more...

Eytan Ruppin

Eytan Ruppin quoted in New York Times story on treating COVID-19

May 15, 2020

The New York Times has reported on a new paper detailing drugs with the potential to treat COVID-19 by researchers from international institutions. Eytan Ruppin, Ph.D., Chief of the Cancer Data Science Laboratory, turned the computer network his lab uses toward analyzing some of the drugs that did best in the screening to predict which are likely to succeed in actual patients and in what combinations. Read more...

Ira Pastan

Ira Pastan selected as a 2020 Sammies finalist

May 4, 2020

Ira Pastan, M.D., Co-Chief of the Laboratory of Molecular Biology, has been selected as one of 27 Samuel J. Heyman Service to America Medal (Sammies) finalists. These finalists are outstanding federal employees who serve the public good and are addressing many of our country’s greatest challenges. Dr. Pastan is nominated for discovering a new class of drugs that can successfully treat a rare form of leukemia and hold promise to be effective therapies for pancreatic and lung cancer as well as mesothelioma. Read more...

John Schiller

John Schiller elected to the National Academy of Sciences

Apr 29, 2020

John T. Schiller, Ph.D., Deputy Chief of the Laboratory of Cellular Oncology, has been elected to the National Academy of Sciences for his distinguished and continuing achievements in original research. Dr. Schiller, in close partnership with Dr. Doug Lowy, has made fundamental contributions to our understanding of human papillomavirus (HPV) culminating in the development of the prophylactic vaccines Cervarix and Gardasil, which protect from HPV-related cancers, including cervical cancer. Read more...

CAR T-cell therapy

NCI initiative aims to boost CAR T-cell therapy clinical trials

Apr 23, 2020

Researchers at the Center for Cancer Research are part of a new NCI initiative to manufacture CAR T-cell therapies for clinical trials being conducted at multiple hospitals. Nirali N. Shah, M.D., Lasker Clinical Research Scholar in the Pediatric Oncology Branch, is a co-lead investigator on the first trial of this initiative that is testing a CAR T-cell therapy designed to target a protein on cancer cells called CD33 in children and young adults with advanced forms of acute myeloid leukemiaRead more...

AACR 2020 logo

CCR presentations at AACR 2020 - Session I

Apr 22, 2020

The American Association for Cancer Research (AACR) Annual Meeting covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world. The 2020 AACR Virtual Annual Meetings I and II will take place April 27-28 and June 22-24, respectively. View the list of CCR presenters for the April meeting.

Andrea Apolo

Andrea Apolo receives Arthur S. Flemming Award

Apr 21, 2020

Andrea B. Apolo, M.D., NIH Lasker Clinical Research Scholar in the Genitourinary Malignancies Branch, is a recipient of this year’s Arthur S. Flemming Award, which honors the accomplishments of mid-career federal employees. Dr. Apolo received the award for her work leading a clinical trial demonstrating that avelumab treatment led to prolonged survival in patients with refractory metastatic urothelial carcinoma. She then led the effort to get avelumab approved by the FDA for the treatment of bladder cancer. Read more...

William Dahut

Dr. William Dahut discusses coronavirus and cancer patients on Frankly Speaking about Cancer podcast

Apr 21, 2020

William L. Dahut, M.D., CCR Clinical Director, was a guest on the Frankly Speaking about Cancer podcast for their spotlight on coronavirus series. He addressed concerns from cancer patients and their caregivers and shared advice on what cancer patients can do to stay safe.  Read more...