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New immunotherapy approach shows potential in some people with metastatic solid tumors, NIH researchers say

Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may be effective in treating metastatic colorectal cancer. In the trial, researchers led by Steven A. Rosenberg, M.D., Ph.D., Chief of the Surgery Branch, genetically engineered lymphocytes (a type of white blood cell) from each patient to produce receptors that recognize and attack their specific cancer cells. The personalized immunotherapy shrank tumors in several patients and was able to keep the tumors from regrowing for up to 7 months.

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Chengkai Dai appointed to Senior Investigator at CCR

The CCR community congratulates Chengkai Dai, Ph.D., who has been appointed Senior Investigator in the Mouse Cancer Genetics Program. Dai’s laboratory is a pioneer in the field of proteomic instability of cancer. His ongoing research focuses on the molecular mechanisms through which proteomic instability may affect genomic stability, cell invasion and autophagy, areas which hold promise to unveil new molecular pathways that could be targeted in cancer therapy.

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