Xavier, a patient in the Pediatric Oncology Branch

Pediatric Oncology Branch patient shares neurofibromatosis journey at NIH

Xavier, a patient in the Pediatric Oncology Branch, was born with an incompletely formed leg bone and a large number of dark spots all over his body. When Xavier broke his weak leg at only 11 months of age, he was diagnosed with neurofibromatosis type 1 (NF1). He cme to the NIH for treatment, and his tumors have shrunk by more than 20 percent thanks to treatment with selumetinibRead more...

Pediatric Oncology Branch patient shares neurofibromatosis journey at NIH
Live-cell fluorescence imaging showing Rabin8, labeled green, binding to Rab11a, labeled red, minutes after serum starvation in

Akt protein kinase pathway regulates key step in the initiation of cilia formation

Jun 13, 2019

CCR investigators have discovered that activating the Akt protein kinase pathway stabilizes the binding of the WDR44 protein to the Rab11 protein. This prevents Rab11 from binding to the Rabin8 protein, thereby blocking cilia formation. When Akt is inactive, though, Rab11 instead is bound by FIP3, enhancing its binding to Rabin8, which helps initiate cilia formation. Since abnormalities in cilia formation are associated with a number of types of cancer, these findings point to several potential targets for cancer therapy.   Read more...

oral squamous cancer cell (white) being attacked by two cytotoxic T cells (red), part of a natural immune response

Registration now open for Cancer and Inflammation: From Micro to Macro

Jun 12, 2019

The Cancer and Inflammation: From Micro to Macro conference, hosted by the CCR Center of Excellence in Immunology, will take place October 17-18, 2019. This two-day national symposium addresses recent advances in the field and should be an exciting forum for discussion and debate on the current understanding of cancer and inflammation. Read more...

Registration now open for Cancer and Inflammation: From Micro to Macro
Conquer Cancer logo

CCR fellows receive Conquer Cancer Foundation of ASCO Young Investigator Awards

Jun 11, 2019

Congratulations to Vid Leko M.D., Lekha Mikkilineni, M.D., and Chen Zhao, M.D., for receiving the Conquer Cancer Foundation of ASCO Young Investigator Award (YIA). The YIA provides funding to promising investigators to encourage and promote quality research in clinical oncology. The purpose of this grant is to fund physicians during the transition from a fellowship program to a faculty appointment. Read more...

CCR fellows receive Conquer Cancer Foundation of ASCO Young Investigator Awards
Supercoiled pre-miR-21

Bacterial compound targets cancer-promoting RNA

Jun 10, 2019

Screening more than 3,000 natural products identified a compound that stops the growth of cancer cells by targeting a growth-promoting microRNA. Read more...

Atlantic Live logo

Nirali Shah and Lori Wiener participate in AtlanticLIVE summit

Jun 6, 2019

Nirali Shah, M.D., MHSc, Investigator in the Pediatric Oncology Branch (POB), and Lori Wiener, Ph.D., DCSW, LCSW-CStaff Scientist in POB, recently participated in an AtlanticLIVE summit called Children and Cancer. During the event, they discussed their work developing immunotherapies and psychosocial standards of care for children with cancer. Watch their respective sessions here and here. Read more...

Nirali Shah and Lori Wiener participate in AtlanticLIVE summit
Udo Rudloff headshot

Udo Rudloff discusses germline mutations with Bloomberg podcast

Jun 6, 2019

Udo Rudloff, M.D., Ph.D., Investigator in the Pediatric Oncology Branch, was recently featured on Bloomberg’s Prognosis podcast.During the episode, “Should We Be Scared of Our DNA?," Dr. Rudloff discussed CDH1 germline mutations and risk of hereditary diffuse gastric cancer (HDGC) in an evolving environment, which he is currently studying as part of the Rare Tumor Initiative. The full podcast is available online. Read more...

Udo Rudloff discusses germline mutations with Bloomberg podcast
Stem cell transplant process

Clinical trial tests new methods for blood stem cell transplant in lymphoma

Jun 6, 2019

Peripheral T-cell lymphoma (PTCL) is a rare, often fast-growing cancer of white blood cells. A new clinical trial is investigating to see how a new approach to blood stem cell transplant can impact patients with PTCL.  Read more...

Immunotherapy depicted with a cell

June is Cancer Immunotherapy Awareness Month

Jun 5, 2019

To celebrate Cancer Immunotherapy Month this June, we are highlighting our researchers who have helped pioneer this research and continue to make seminal advances in this growing field.  Read more...

June is Cancer Immunotherapy Awareness Month
Head and neck cancer regions

Investigators test combination therapy for head and neck squamous cell carcinoma in new trial

Jun 4, 2019

Patients with recurrent head and neck squamous cell carcinoma (HNSCC) may be eligible to participate in a new clinical trial at the NIH Clinical Center. This trial tests a therapy of a novel radiosensitizer, birinapant, in combination with radiotherapy for patients whose HNSCC has come back at or near the place of the original tumor. Read more...

Frontiers meeting info

Registration now open for Frontiers in Light Microscopy

Jun 3, 2019

The Frontiers in Light Microscopy conference is a platform to discuss the latest advances in microscopy and biological imaging.  The current state of the art in light microscopy will be presented by leading researchers in the field who will cover topics such as intravital imaging, super-resolution microscopy and light sheet microscopy. Sessions will include organelle dynamics and function, multicellular organisms and imaging the immune system. Read more...

Registration now open for Frontiers in Light Microscopy

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