News and Events
Drug shrinks nerve tumors in adults with neurofibromatosis type 1 in a clinical trial
Until recently, no effective treatments existed for non-cancerous inoperable nerve tumors, called plexiform neurofibroma, in adults. A clinical trial of the drug selumetinib shows it can cause tumor shrinkage and relieve symptoms, such as pain.
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Nirali Shah elected to the American Society for Clinical Investigation
Nirali N. Shah, M.D., M.H.Sc., Lasker Clinical Research Scholar in the Pediatric Oncology Branch, was elected as a member of the American Society for Clinical Investigation (ASCI). The organization seeks to support the scientific efforts, educational needs, and clinical aspirations of physician-scientists to improve the health of all people. The 2025 newly elected members came from 46 different institutions and represent excellence across the breadth of academic medicine.
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Clinical trial researching immunotherapy for solid tumors
A clinical trial led by Danielle M. Pastor, D.O., Ph.D., Assistant Research Physician in the Center for Immuno-Oncology, is researching immunotherapy for adults with advanced solid tumors.
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Clinical trial researching combination drug therapy for neuroendocrine carcinomas
A clinical trial led by Jaydira Del Rivero, M.D., Associate Research Physician in the Developmental Therapeutics Branch, is researching combination drug therapy for adults with high-grade neuroendocrine carcinomas.
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Celebrating CCR Careers: Jay A. Berzofsky, M.D., Ph.D.
Jay A. Berzofsky, M.D., Ph.D., a chemist-turned-immunologist who pioneered cancer immunology and immunotherapy strategies, announces his retirement from the NCI.
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Empowering others to contribute to rare neuroendocrine tumor research
Lacey Koelling was diagnosed with paraganglioma tumors in 2018, which began to metastasize five years later. She enrolled in an NIH trial to contribute to research on this rare cancer.
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An observant patient opens new doors for cancer screening
David Drash enrolled in a CCR clinical trial when he was diagnosed with BAP1 tumor predisposition syndrome (TPDS) in 2022. He noticed that everyone in his family with BAP1 TPDS had white lines on their fingernails; his observation led to the discovery of a new detection tool.
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Celebrating CCR Careers: Alan Rein, Ph.D.
Alan Rein, Ph.D., is a known expert in the field of viral assembly, particularly in retroviruses like the human immunodeficiency virus (HIV). After an extensive career studying molecular mechanisms of retroviral replication and pathogenesis, he has announced his retirement.
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Clinical trial researching MRI software for mapping prostate cancer
A clinical trial led by Ismail Baris Turkbey, M.D., Senior Clinician in the Molecular Imaging Branch, is researching a software that can analyze radiographic images of the prostate for cancer detection and diagnosis.
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Mutant RAS can shift other proteins’ positions inside cancer cells
Mutant RAS proteins help shuttle other proteins out of the cell nucleus and into the cytoplasm, where some can promote cancerous growth.
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Clinical trial researching combination drug therapy for Ewing sarcoma and rhabdomyosarcoma
A clinical trial led by Christine M. Heske, M.D., Investigator in the Pediatric Oncology Branch, is researching combination drug therapy for adolescents and young adults with Ewing sarcoma and rhabdomyosarcoma.
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