Clinical trial will test radiotracer imaging for high-risk localized prostate cancer

Many men with prostate cancer are diagnosed at an early stage of the disease when the cancer is confined to the prostate. However, about 20 percent are diagnosed with high-risk disease, which tends to spread, or metastasize, to other parts of the body. William Dahut, M.D., Senior Investigator in the Genitourinary Malignancies Branch, is leading a study using positron emission tomography/computed tomography (PET/CT) with radioactive material to try and identify places in the body where prostate cancer has spread. Read more...

Mitochondrial shape in pancreatic cancer

Computational analysis leads to potential new drug combination for pancreatic cancer

Nov 20, 2019

A computer analysis has been able to predict that low levels of asparagine, an amino acid required for protein synthesis, combined with the shutdown of a stress response pathway can lead to reductions in the fitness of a tumor. These combined findings could potentially lead to new combination therapies to treat aggressive tumors, such as those found in pancreatic cancers. Read more...

Fusing a ring system onto an existing chromophore

New video: Discovering new far-red fluorescent probes

Nov 18, 2019

Fluorescent probes are workhorse molecules used by biologists to illuminate the inner workings of cancer cells. By lighting up cell components of interest, researchers can then observe cells in action through high-powered microscopes. This new video explains a novel class of far-red fluorescent probes synthesized by Martin Schnermann, Ph.D., Senior Investigator in CCR’s Chemical Biology Laboratory, and his team. Read more...

hairy cell leukemia

Clinical trial tests combination therapy for relapsed hairy cell leukemia

Nov 15, 2019

Hairy cell leukemia (HCL) is a rare and slow-growing leukemia in which bone marrow overproduces abnormal B lymphocytes, a type of white blood cell. Under a microscope, these malignant cells appear to be covered with tiny hair-like projections. In this study, patients will receive an immunotoxin called moxetumomab pasudotox to study its effect on relapsed HCL. Read more...

pancreatic cancer cells

Pancreatic Cancer Research

Nov 4, 2019

November is Pancreatic Cancer Awareness Month. We have many researchers, both in the basic and clinical disciplines, who are working on pancreatic cancer.  Learn more...

Lung cancer cells

Lung Cancer Research

Nov 4, 2019

November is Lung Cancer Awareness Month. Our research portfolio includes investigators making important discoveries in lung cancer research.  Read more...

Elaine Jaffe

Elaine Jaffe named an NIH Distinguished Investigator

Oct 29, 2019

Elaine Jaffe, M.D., Senior Investigator in the Laboratory of Pathology, has been selected as an NIH Distinguished Investigator, a prestigious title reserved for tenured intramural senior investigators who are at the highest level in their fields. Dr. Jaffe has conducted pioneering studies related to the classification of malignant lymphomas and has led an international effort for consensus among clinicians and pathologists. Read more...

Pancreatic cancer cells

Clinical trial will test new treatment to improve survival rates for patients with operable gastrointestinal tumors

Oct 28, 2019

A clinical phase II trial at the NIH Clinical Center will test the effectiveness of a monoclonal antibody used immediately before and after surgery for patients with primary pancreatic and bile duct cancer and those who have liver metastasis from colorectal cancer. The trial is investigating whether this treatment can prevent the disease from coming back after surgery. Read more...

liver anatomy

Clinical trial studies antibiotic therapy for fibrolamellar hepatocellular carcinoma, a rare liver cancer

Oct 25, 2019

Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer that usually grows in teens and young adults. Unresectable FLC usually does not improve with surgery, chemotherapy or radiation therapy. Tim F. Greten, M.D., Deputy Chief of the Thoracic and GI Malignancies Branch, is leading a study that tests the theory that certain bacteria in the gut may influence the development of FLC. Read more...

James Kochenderfer

James Kochenderfer receives 2019 FNIH Trailblazer Prize for Clinician-Scientists

Oct 24, 2019

James Kochenderfer, M.D., Investigator in the Surgery Branch, has received the 2019 Foundation for the National Institutes of Health (FNIH) Trailblazer Prize for Clinician-Scientists. The award recognizes the outstanding contributions of early career clinician-scientists whose work has the potential to or has led to innovations in patient care. Dr. Kochenderfer was selected as the 2019 recipient for developing immunotherapies that leverage chimeric antigen receptor (CAR) T cells to treat blood cancers, including lymphoma and multiple myeloma. Read more...

Samantha Seinfeld

Metastatic breast cancer survivor shares her clinical trial story

Oct 23, 2019

We’re celebrating breast cancer awareness month by sharing the story of Samantha Seinfeld, a metastatic breast cancer survivor who participated in a CCR first-in-human clinical trial over 10 years ago. Since then, she has remained cancer-free. Margaret Gatti-Mays, M.D., M.P.H., F.A.C.P., Assistant Research Physician in the Laboratory of Tumor Immunology and Biology, and James Gulley, M.D., Ph.D., Chief of the Genitourinary Malignancies Branch, are currently evaluating Samantha’s unusual immune response in hopes of improving the responses of other patients. Read more...

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