Combination therapy tested in clinical trial for metastatic genitourinary cancers

Genitourinary cancers are common but difficult to treat with chemotherapy or immunotherapy alone. A new clinical trial studies two drugs that intensify the immune system’s attack on cancer cells. Read more...

neutrophils

Innovative imaging tools reveal how neutrophils fight inflammation in mice

Sep 9, 2020

CCR researchers used state-of-the-art imaging techniques to observe, in real time, the path neutrophils take as they move toward a site of inflammation in a mouse model. The images showed the neutrophils leaving the blood vessels and engaging with bacteria that had been introduced into the mouse’s footpad. These observations led to the team’s discovery that the leukocyte LTB4 directs the recruitment, engagement, and penetration of neutrophils into inflamed tissues. Read more...

CAR-T therapy

FDA grants rare pediatric disease designation for experimental immunotherapy for acute lymphoblastic leukemia

Sep 3, 2020

A cell-based immunotherapy that is currently being evaluated at the NIH Clinical Center for the treatment of B-cell acute lymphoblastic leukemia (ALL) has been designated by the U.S. Food and Drug Administration as a drug for a rare pediatric disease. Designation could encourage development of this novel therapy for children with relapsed or refractory ALL. Read more...

Immunotherapy cells

In mice, new therapeutic strategy enhances the effects of immunotherapy in high ASS1-expressing cancers

Aug 31, 2020

Many prevalent cancers (e.g., lung, breast and colon) exhibit abnormally high expression of the enzyme ASS1. This results in greater production of genetic material incorporating purines, consequently making these tumors more resistant to immunotherapy. The researchers showed that drugs blocking purine production in these tumors enhance their response to immunotherapy. Read more...

Lymphoma

Our leukemia and lymphoma research

Aug 27, 2020

September is leukemia and lymphoma awareness month. Lymphoma is a broad term for cancer that begins in cells of the lymph system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). Leukemia is a broad term for cancers of the blood cells. The type of leukemia depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly. To learn more about our leukemia and lymphoma research, click here.

SARS-CoV-2 virus

Experimental compound blocks SARS-CoV-2’s ability to infect and kill cells in the lab

Aug 25, 2020

A potential therapy for COVID-19 binds to a viral enzyme that SARS-CoV-2 requires for replication. With further development and testing, it might be an effective treatment for people with the disease. Read more...

TILs in culture

Clinical trial studies three immunotherapies given before surgery in newly diagnosed head and neck cancers not caused by HPV

Aug 20, 2020

Newly diagnosed head and neck cancer not caused by HPV infection often uses surgery as the first treatment. After surgery, about half of patients with head and neck squamous cell carcinoma (HNSCC) that was not caused by the human papillomavirus (HPV) will have disease relapse within two years. Jason Redman, M.D., Assistant Research Physician in the Genitourinary Malignancies Branch, is leading a trial of three proposed immunotherapy treatments given before surgery for HNSCC. Read more...

Breast cancer cells

Epigenetic marker contributes to PARP inhibitor resistance

Aug 19, 2020

CCR scientists have discovered a way cancer cells can become resistant to PARP inhibitors, targeted therapies that are used to treat some ovarian, breast and prostate cancers. Read more...

RNA strand

New synthetic compounds alter RNA expression in bacteria

Aug 18, 2020

Researchers have succeeded in developing a number of different compounds that bind to ZTP riboswitches, which regulate RNA, in bacteria. Their approach could one day be used to create a new class of antibacterial drug. Read more...

Adam Sowalsky, Ph.D.

A Conversation with Adam Sowalsky, Ph.D.

Aug 4, 2020

Adam Sowalsky, Ph.D., is an Investigator in the Laboratory of Genitourinary Cancer Pathogenesis. He is seeking to tease apart the molecular mechanisms underlying prostate cancers that have a high likelihood of progressing and then identifying patients who might benefit from earlier therapy. He discusses what motivated him to pursue a career in cancer biology as well as what lies ahead for his research. Read more...

Patient scan

Clinical trial evaluates radiopharmaceutical as therapy for biochemically recurrent prostate cancer

Jul 28, 2020

Some men who have been treated for localized prostate cancer (PC) with surgery or radiation still have signs of the disease that are only detected by a blood test (a rising prostate specific antigen or PSA). This is called biochemically recurrent prostate cancer (BCRpc). Investigators in the Center for Cancer Research are leading a clinical trial exploring an option meant to be less toxic for treating BCRpc, which may impact microscopic bone disease seen only on PET scans, using radium-223. Read more...

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