Near-infrared compounds for visualizing enzymatic activity in living organisms

New fluorescent probes developed that can help clinicians pinpoint cancer metastases

New chemical compounds developed by CCR researchers and clinicians are safe and highly effective in fluorescently highlighting microscopic metastases. The new compounds could have great utility in complex living systems based on experiments done in mouse models of metastatic human ovarian cancer. Read more...

figure 8 from publication

A key mechanism that fuels uncontrolled cell growth is uncovered in yeast

Feb 16, 2021

Scientists have long wondered how cancer cells use a protein complex, called TOR, to survive and proliferate in nutrient-poor conditions. Now, CCR researchers have discovered how a protein that is targeted by TOR drives this process, which holds important implications for understanding cancer and some genetic disorders. Read more...

RNA

Registration and abstract submission now open for RNA Biology Symposium

Feb 10, 2021

The symposium offers the opportunity to learn more about the current status of RNA biology in development and disease, share research with leading figures in the field and discuss the use and implications of these advances for clinical applications. Sessions Include: RNA Processing; RNA Structure and Mechanism; Non-Classical RNAs; and RNA Therapy. Learn more...

amplified TNIK contributes to LSCC progression

Potential therapeutic target for lung squamous cell carcinoma identified

Feb 9, 2021

CCR researchers have identified the protein TNIK as a therapeutic target for lung squamous cell carcinoma, the second most common type of lung cancer. Using human lung cancer cells transplanted into preclinical models, researchers found that the cells responded to a pharmacological treatment that inhibited TNIK and also resulted in cell death in the transplanted tumor cells. Read more...

anatomy of thymus gland

Clinical trial studies immunotherapy combination for recurrent thymoma and thymic carcinoma

Feb 9, 2021

Thymic epithelial tumors (TETs) are rare cancers that originate from the cells of the thymus, a small organ that sits in the chest between the lungs and above the heart. Arun Rajan, M.D., Senior Clinician in the Thoracic and GI Malignancies Branch, is leading a clinical trial of a therapy for thymoma and thymic carcinoma that has returned after chemotherapy and cannot be treated with surgery. Read more...

fecal microorganisms

Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy

Feb 4, 2021

A collaborative study between the National Cancer Institute (NCI) and the UPMC Hillman Cancer Center at the University of Pittsburgh suggests that fecal microbiota transplants can help patients with advanced melanoma respond to immunotherapy. “Our study is one of the first to demonstrate in patients that altering the composition of the gut microbiome can improve the response to immunotherapy,” says study co-leader Giorgio Trinchieri, M.D., Chief of CCR’s Laboratory of Integrative Cancer ImmunologyRead more...

DNA-targeted chemotherapy

New way to address chemoresistance linked to the protein SLFN11

Jan 29, 2021

CCR researchers have discovered two complementary roles for the protein Schlafen-11 (SLFN11) in determining patient response to chemotherapy. These findings have implications for how to overcome this resistance and provide new treatment options for patients with small cell lung cancer (SCLC) and many other cancers. Read more...

small cell lung carcinoma

Genetics, not just smoking, influence small cell lung cancer risk

Jan 27, 2021

People with mutations in DNA repair genes may be more likely than others to develop small cell lung cancer. Identifying these mutations in patients could help guide treatment decisions. Read more...

DNA damage during a critical phase in the cell cycle called G1

New findings show how damaged cells survive the cell cycle

Jan 13, 2021

As cells divide and replicate, important safety checkpoints are in place to ensure that most faulty cells with damaged DNA do not survive the cell cycle. In a new twist, CCR researchers discovered how some damaged cells use molecular inertia to drive past these safety checkpoints and continue through the cell cycle. Read more...

damaged mitochondria

New insights into what fuels an aggressive form of kidney disease

Jan 5, 2021

Researchers have uncovered a key mechanism behind an aggressive form of kidney cancer, whereby cells lacking an important enzyme are unable to replicate and maintain healthy mitochondrial DNA. This results in more genetic abnormalities in the cells, fueling the growth and spread of cancer. Read more...

skin biopsy

Clinical trial studies therapy for relapsed/refractory T-cell malignancies

Jan 5, 2021

Milos Miljkovic, M.D., M.Sc., Assistant Research Physician in the Lymphoid Malignancies Branch, is leading a study of a 4-drug combination treatment strategy using romidepsin, oral 5-azacitidine, dexamethasone and lenalidomide for T-cell malignancies (TCMs). Researchers are seeking to determine the safety, side effects, and best dose of this 4-drug combination for people with relapsed/refractory TCM.  Read more...

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