New findings show how damaged cells survive the cell cycle

As cells divide and replicate, important safety checkpoints are in place to ensure that most faulty cells with damaged DNA do not survive the cell cycle. In a new twist, CCR researchers discovered how some damaged cells use molecular inertia to drive past these safety checkpoints and continue through the cell cycle. Read more...

Combination therapy tested in clinical trial for metastatic genitourinary cancers

Oct 20, 2020

Genitourinary cancers are common but difficult to treat with chemotherapy or immunotherapy alone. A new clinical trial studies two drugs that intensify the immune system’s attack on cancer cells. Read more...

NAM logo

Peter Choyke and Louis Staudt elected to the National Academy of Medicine

Oct 19, 2020

Peter Choyke, M.D., F.A.C.R., Chief of the Molecular Imaging Branch, and Louis Staudt, M.D., Ph.D., Chief of the Lymphoid Malignancies Branch, have been elected to the National Academy of Medicine (NAM). Dr. Choyke is elected for pioneering advances in the imaging of prostate cancer that have enabled accurate localization of clinically significant tumors. Dr. Staudt is elected for demonstrating that genetic profiling can distinguish lymphoma subtypes, predict patient survival, and individualize therapy, thus playing a key role in launching the era of cancer precision medicine. Read more...

Lymphoma mass before and after treatment

Phase 1 CAR T-cell therapy leads to years-long remissions in relapsed B-cell lymphoma patients

Oct 13, 2020

In a Journal of Clinical Oncology article, results of a phase 1 trial by CCR investigators show that CAR T-cell therapy can result in long-lasting remissions in patients with certain relapsed B-cell lymphomas. Many who had life expectancies of only six months or less during the clinical trial of the therapy, which spanned from 2009 to 2015, remain in complete remission. Read more...

HPV-16 E5 Oncoprotein

Clinical trial tests immunotherapy combination for advanced HPV-associated cancers

Oct 13, 2020

Human papillomavirus (HPV) is the most common sexually transmitted infection. More than 30,000 cases of HPV+ cancers occur every year in the United States. CCR investigators are leading a study using a combination of 3 immunotherapy drugs to treat HPV+ cancers. Read more...

structure of HPV 16

Clinical trial tests vaccine for late-stage HPV-linked tumors

Oct 7, 2020

The human papillomavirus (HPV) has been linked to many kinds of cancer, including cervical, uterine, vaginal, penile and oropharyngeal. For those who develop advanced HPV-linked cancer, the NIH Clinical Center has a clinical trial open to test a vaccine with and without checkpoint inhibitors to see if this treatment approach can stop tumor growth. Read more...

bone anatomy

Lymphoma therapy drug tested as early treatment for chronic graft-versus-host disease

Oct 6, 2020

cGvHD can occur after a person has had a stem cell or bone marrow transplant. In some cases, the donated bone marrow/stem cells view the host's body as foreign and start to attack it. cGvHD can occur at any time after a transplant, but it's more common after the marrow/stem cells have created a new immune system in the host's body. A clinical trial is studying the lymphoma therapy drug ibrutinib to see if early treatment can prevent the most severe symptoms of cGvHD. Read more...

Dr. Ira Pastan

Ira Pastan receives 2020 Paul A. Volcker Career Achievement award

Oct 5, 2020

Ira Pastan, M.D., NIH Distinguished Investigator and Co-Chief of the Laboratory of Molecular Biology, has received the 2020 Paul A. Volcker Career Achievement Medal from the Partnership for Public Service’ Service to America Medals, also known as the SAMMIES. The Paul A. Volcker Career Achievement Medal recognizes federal employees who have led significant and sustained achievements over 20 or more years of service in government. Dr. Pastan was recognized for discovering a new class of drugs that can successfully treat a rare form of leukemia and hold promise to be effective therapies for pancreatic and lung cancer as well as mesothelioma. Read more...

APS logo

Ruth Nussinov and Kandice Tanner named American Physical Society Fellows

Oct 5, 2020

Ruth Nussinov, Ph.D., Senior Investigator in the Laboratory of Cancer Immunometabolism, and Kandice Tanner, Ph.D., Senior Investigator in the Laboratory of Cell Biology, were named as American Physical Society Fellows. The fellowship program recognizes members who made advances in physics through original research and publication or made significant innovative contributions in the application of physics to science and technology. Read more...

Jordan Meier

Jordan Meier receives the 2021 Eli Lilly Award in Biological Chemistry

Oct 5, 2020

Jordan Meier, Ph.D., Senior Investigator in the Chemical Biology Laboratory, received the 2021 Eli Lilly Award in Biological Chemistry for outstanding research of unusual merit and independence of thought and originality. Dr. Meier’s efforts in defining how metabolism regulates epigenetic signaling in cancer and how metabolite-protein interactions occur in all living organisms were cited as meritorious examples of advancing two fundamental areas of research. Read more...

Sue Wickner

Sue Wickner receives the 2021 American Society for Microbiology Award for Basic Research

Oct 5, 2020

Sue Wickner, Ph.D., Senior Investigator in the Laboratory of Molecular Biology, received the 2021 American Society for Microbiology Award for Basic Research. The award recognizes outstanding scientists whose discoveries have been fundamental to advancing our understanding of the microbial world. Dr. Wickner’s research into the mechanisms of action of molecular chaperones aims to provide insight for future development of drugs for the prevention and treatment of diseases caused by protein aggregation and misfolding, including Alzheimer's, Parkinson's, type II diabetes, cystic fibrosis, and prion diseases. Read more...