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Anish  Thomas, MBBS, M.D.

Anish Thomas, MBBS, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Developmental Therapeutics Branch

RESEARCH SUMMARY

I am a clinical researcher with a focus on small cell lung cancer, one of the most aggressive cancers. The goals of my research program are: 1) to systematically develop more effective therapies for patients with SCLC and similar chemotherapy-refractory tumors by targeting key pathways involved in DNA replication, repair, and chromatin remodeling, and 2) genomic characterization of SCLC to understand the biology of treatment response and resistance, and to translate these findings into new treatment approaches.

Areas of Expertise

1) small cell lung cancer 2) DNA damage response 3) immune response 4) genomic instability 5) replication stress 6) immunotherapy

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.

Clinical Trials

Publications

Selected Recent Publications

Clinical and Genomic Characteristics of Small Cell Lung Cancer in Never Smokers: Results From a Retrospective Multicenter Cohort Study

Thomas A, Mian I, Tlemsani C, Pongor L, Takahashi N, Maignan K, Snider J, Li G, Frampton G, Ali S, Kim S, Nichols S, Rajapakse V, Guha U, Sharon E, Fujimoto J, Moran CA, Wistuba II, Wei JS, Khan J, Szabo E, Torres AZ, Carson KR
Chest. Oct;158(4):1723-1733: 2020. [ Journal Article ]

Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study

Thomas A, Vilimas R, Trindade C, Erwin-Cohen R, Roper N, Xi L, Krishnasamy V, Levy E, Mammen A, Nichols S, Chen Y, Velcheti V, Yin F, Szabo E, Pommier Y, Steinberg SM, Trepel JB, Raffeld M, Young HA, Khan J, Hewitt S, Lee JM.
J Thorac Oncol. 14(8): 1447-57, 2019. [ Journal Article ]

Phase I Study of ATR inhibitor M6620 in Combination with Topotecan in Patients with Advanced Solid tumors

Thomas A, Redon C, Sciuto L, Padiernos E, Jiuping Ji, Lee M-J, Lee S, Zhang Y, Tran L, Yutzy W, Rajan A, Guha U, Chen H, Hassan R, Alewine C, Bates S, Kinders R, Steinberg S, Doroshow J, Aladjem M, Trepel J, Pommier Y
J Clin Oncol. 36(16): 1594-1602, 2018. [ Journal Article ]

Small cell lung cancer: time to revisit the DNA damaging chemotherapy strategy

Thomas A, Pommier Y.
Sci Transl Med. 8(346): 346fs12, 2016. [ Journal Article ]

Job Vacancies

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Team

Physician Assistant (Contr.)
Samantha Nichols
Scientist (Contr.)
Vinod Rajapakse, Ph.D.
Research Nurse Specialist
Linda Sciuto, R.N., B.S.N., O.C.N.
Research Nurse Specialist
Rasa Vilimas, R.N., B.S.N.
Biologist
Yang Zhang, Ph.D.