Hernandez clinical trial conversation

Clinical Trial Conversation: Jonathan Hernandez describes metastatic colorectal cancer clinical trial

Jul 8, 2019

Colorectal cancer (CRC) starts in the colon and/or rectum and often metastasizes, or spreads, to many sites in the body. In a certain set of patients, however, CRC metastasizes only to the liver. Jonathan Hernandez, M.D., of the Surgical Oncology Program, is leading a new clinical trial to study how well CRC patients with liver-only metastases respond to treatment with a hepatic artery infusion pump. Dr. Hernandez describes the trial in this new video. Read more...

Clinical Trial Conversation: Jonathan Hernandez describes metastatic colorectal cancer clinical trial
Combination IL-15

Clinical trial tests immunotherapy combination to treat T-cell cancers

Jun 28, 2019

The Center for Cancer Research’s Lymphoid Malignancies Branch is testing a combination treatment for patients whose mature T-cell cancer has returned after therapy or has not responded to therapy using avelumab, an immunotherapy agent that enhances the activity of immune cells and blocks a protein pathway that allows cancer cells to hide from the immune system. Read more...

HPV 16

Clinical trial will test immunotherapy against precancerous vulvar lesions

Jun 27, 2019

Scientists at the Center for Cancer Research are launching a phase II clinical trial to evaluate the effect of a single immunotherapy treatment on precancerous lesions that put women at risk for vulvar cancer. Like the cell-based immunotherapies now used to treat certain blood cancers, the experimental treatment aims to use patients’ own immune cells to fight disease. Read more...


Pediatric Oncology Branch patient shares neurofibromatosis journey at NIH

Jun 18, 2019

Xavier, a patient in the Pediatric Oncology Branch, was born with an incompletely formed leg bone and a large number of dark spots all over his body. When Xavier broke his weak leg at only 11 months of age, he was diagnosed with neurofibromatosis type 1 (NF1). He came to the NIH for treatment, and his tumors have shrunk by more than 20 percent thanks to treatment with selumetinib. Read more...

Pediatric Oncology Branch patient shares neurofibromatosis journey at NIH
Stem cell transplant process

Clinical trial tests new methods for blood stem cell transplant in lymphoma

Jun 6, 2019

Peripheral T-cell lymphoma (PTCL) is a rare, often fast-growing cancer of white blood cells. A new clinical trial is investigating to see how a new approach to blood stem cell transplant can impact patients with PTCL.  Read more...

Head and neck cancer regions

Investigators test combination therapy for head and neck squamous cell carcinoma in new trial

Jun 4, 2019

Patients with recurrent head and neck squamous cell carcinoma (HNSCC) may be eligible to participate in a new clinical trial at the NIH Clinical Center. This trial tests a therapy of a novel radiosensitizer, birinapant, in combination with radiotherapy for patients whose HNSCC has come back at or near the place of the original tumor. Read more...

Drawing of inside of brain

Clinical trial tests a new drug therapy for recurrent ependymomas of the brain and spinal cord

May 28, 2019

Ependymomas are rare tumors that arise in the ependyma, the thin membrane that lines fluid-filled cavities in the brain and spinal cord, and there are limited treatment options for those that have already been treated with standard therapies. A new clinical trial is testing a drug that targets ependymomas that have a specific genetic signature. Read more...

Doctor with patient

Clinical study follows men with specific genetic changes to determine their risk for developing prostate cancer

May 16, 2019

Prostate cancer (PC) is the most common malignancy in American men. There is increasing evidence that there may be a link between PC and men who have a family history of ovarian or breast cancer. As researchers have learned more about the role of genetics in PC, they have taken a new approach to screening for the disease—targeting men whose genetic profiles put them at risk for developing PC. Read more...

hepatocellular carcinoma

Clinical trial to determine whether antibiotics can boost immune response in treating liver cancer

May 14, 2019

A new clinical trial at the NCI’s Center for Cancer Research is set to explore if eliminating certain bacteria in the gut will boost the immune system response in patients who have hepatocellular carcinoma and liver metastases. 


histological slide of prostate cancer

New clinical trial tests radiotracer for improved imaging of metastatic prostate cancer

Apr 22, 2019

Most forms of prostate cancer have receptors for prostate-specific membrane antigen (PSMA), a protein that helps fuel the development of prostate cancer cells. Investigators are studying if a radiotracer that binds to PSMA may improve imaging methods to find sites of metastatic prostate cancer. Read more...