Mesothelioma microenvironment

Clinical trial studies benefit of targeted drug for malignant mesothelioma

Jul 11, 2018

Malignant mesothelioma is cancer that begins in a layer of specialized cells called the mesothelium that line the outer surface of most internal organs. A team led by Raffit Hassan, M.D., of the Thoracic and GI Malignancies Branch aims to see if the drug olaparib causes mesothelial tumors to shrink in patients with mutated BAP-1 or other DNA damage-repair genes and in patients with no mutations in these genes.  Read more...

immunotherapy

Clinical trial tests combinations of immunotherapy drugs for prostate cancer

Jun 20, 2018

Metastatic castration-resistant prostate cancer (mCRPC) is a disease that has spread beyond the prostate and no longer responds to hormone therapy. James Gulley, M.D., Ph.D., of the Genitourinary Malignancies Branch is leading a study of combination immunotherapy where patients will be treated with two, three or four drugs that affect the immune system in different ways to determine the safety of various combinations and whether they can make tumors shrink. Read more...

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Steve Rosenberg featured in CBS News story profiling an immunotherapy clinical trial patient

Jun 11, 2018

When standard treatment failed to eliminate her late-stage breast cancer, Judy Perkins turned to a clinical trial led by Steven Rosenberg, M.D., Ph.D., Chief of the Surgery Branch at the Center for Cancer Research. The trial uses a novel immunotherapy approach of multiplying specific cancer-fighting cells and injecting them into a patient’s bloodstream to kill the cancer. In a recent interview with CBS News’ Jonathan LaPook, Perkins — who remains cancer free more than two years later — shares her clinical trial experience.  Read more...

Steve Rosenberg featured in CBS News story profiling an immunotherapy clinical trial patient
Breast cancer scan

Findings from clinical trial led by Steve Rosenberg published in Nature Medicine

Jun 4, 2018

Findings from a clinical trial led by Steve Rosenberg, M.D., Ph.D., Chief of the Surgery Branch, were recently published in Nature Medicine. The ongoing phase II trial explores a novel approach to immunotherapy that led to the complete regression of breast cancer in a patient who was unresponsive to all other treatments. Using a modified form of adoptive cell transfer, investigators aim to target tumor cell mutations to shrink tumors in patients with common epithelial cancers. According to Dr. Rosenberg, “This research is experimental right now. But because this new approach to immunotherapy is dependent on mutations, not on cancer type, it is in a sense a blueprint we can use for the treatment of many cancer types.”  Read more...

Findings from clinical trial led by Steve Rosenberg published in Nature Medicine
Lipogenesis in Prostate Cancer

Combination therapy for biochemically recurrent prostate cancer tested in new trial

May 31, 2018

Prostate-specific antigen (PSA) is an enzyme released by the prostate gland and is found in abnormally high concentrations in the blood of men with prostate cancer. “Biochemical recurrence” is when PSA levels continue to rise after initial treatment for prostate cancer, such as surgery or radiation. Marijo Bilusic, M.D., of the Genitourinary Malignancies Branch is leading the Center for Cancer Research’s effort in a study to treat men with biochemically recurrent prostate cancer with a combination drug therapy. Read more...

Mesothelioma Spheroid

Clinical trial tests drug combination in mesothelioma of the lung or abdomen

May 29, 2018

Mesothelioma is an aggressive form of cancer caused by asbestos with no known cure and a very poor prognosis. Raffit Hassan, M.D., of the Thoracic and GI Malignancies Branch is leading a study to determine a safe dose of a combination drug therapy in patients with advanced mesothelioma.  Read more...

Pancreatic cancer

Clinical trial investigates experimental drug for advanced pancreatic cancer

May 23, 2018

The pancreas, a large gland that sits behind the stomach, produces enzymes that aid digestion and hormones that regulate blood sugar. Pancreatic cancer develops when cells that make up the ducts in the pancreas start to grow out of control. Udo Rudloff, M.D., is leading a clinical trial of a combination immunotherapy regimen to optimally help the immune system attack the tumor. Read more...

T cell

New trial engineers immune cells to treat solid tumors

May 18, 2018

No existing systemic treatments can currently eradicate the great majority of metastatic solid cancers. To meet that need, Steve Rosenberg, M.D., Ph.D., is testing a new immunotherapy that targets each tumor’s unique genetic mutations in a clinical trial. Read more...

Epstein-Barr virus

New clinical trial uses targeted cancer drug for lymphatic system disease

May 16, 2018

Nivolumab is a targeted cancer drug that blocks the action of a protein called PD-1 and activates T cells to attack cancer cells without damaging normal cells. Mark Roschewski, M.D., of the Lymphoid Malignancies Branch is leading a study to determine if nivolumab is effective in treating patients with certain diseases of the lymphatic system. Read more...

HPV

Clinical trial tests first-in-class bifunctional immunotherapy drug in HPV-associated cancers

May 14, 2018

HPV-associated cancers that spread or do not respond to treatment are often incurable. Julius Strauss, M.D., of the Laboratory of Tumor Immunology and Biology is testing a first-in-class bifunctional immunotherapy to see if it can control the growth of HPV-associated tumors by restoring and improving the immune system’s ability to kill cancer cells. Read more...

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