Boy playing with cars

Clinical trial studies new therapy in children and adults with neurofibromatosis-related GIST

Nov 28, 2018

Patients with neurofibromatosis type 1 (NF1) have an increased risk of developing gastrointestinal stromal tumors (GIST). There is currently no effective medical therapy for GIST that cannot be completely resected. Brigitte Widemann, M.D., Chief of the Pediatric Oncology Branch, is leading a study to see if NF1-related GIST responds to treatment with selumetinib, which blocks a signaling protein called MEK. Read more...

HPV oncogene

New immunotherapy clinical trial tests therapy for recurrent respiratory papillomatosis

Nov 23, 2018

Recurrent respiratory papillomatosis (RRP) is a rare disease caused by infection with human papillomavirus (HPV). The tumors vary in size, grow very quickly and may grow back after they have been removed, meaning patients often need to have multiple surgeries. Christian Hinrichs, M.D., of the Experimental Transplantation and Immunology Branch is leading a trial of an experimental immunotherapy drug called M7824 in patients with recurring RRP. Read more...

Polyploid giant cancer cell

Clinical trial tests safety and dosing of NEO-201 antibody in patients with advanced cancer

Nov 20, 2018

A new treatment for advanced solid tumors will use a preparation derived from human tumor tissue, NEO-201, bound to a modified version of carcinoembryonic antigen-related cell adhesion molecules that block immune cells such as T cells and natural killer cells from attacking tumors. NEO-201 also helps to bring certain immune cells to the tumor, increasing their natural function of attacking cancer cells.  Read more...

Ovarian cancer

Clinical trial tests customized treatment for ovarian cancer and peritoneal mesothelioma

Nov 15, 2018

Ovarian cancer includes cancer of the ovaries, fallopian tubes or abdominal lining (peritoneum). Peritoneal mesothelioma is a type of cancer that affects the peritoneum and is caused by ingesting asbestos fibers. In a new clinical trial, a drug derived from the patient’s own white blood cells will be customized and infused back into the patient’s body to try and combat cancer cells. Read more...

Mesothelioma Spheroid

Clinical trial tests combination therapy for malignant mesothelioma

Nov 13, 2018

Mesothelioma develops in the thin layer of tissue lining the chest or abdomen, often following exposure to airborne asbestos particles. In this study, patients will receive a combination of a targeted immunotherapy and an immunotherapy agent that blocks a protein pathway that allows cancer cells to hide from the immune system. Investigators aim to see how well patients with mesothelioma respond to this treatment.  Read more...

Renal cell carcinoma

Clinical trial evaluates small molecule inhibitor in von Hippel-Lindau disease-associated renal cell carcinoma

Oct 26, 2018

Von Hippel-Lindau (VHL) disease is a hereditary condition that causes an increased risk of developing tumors in several organs, including the kidneys. A new clinical trial is testing a small molecule inhibitor drug to see if it can suppress specific protein activity and thus shrink renal cell carcinoma tumors. Read more...

non-Hodgkin lymphoma

Clinical trial tests multiple targeted agents for treatment of non-Hodgkin lymphoma

Oct 23, 2018

There are very few effective therapies for relapsed or refractory non-Hodgkin lymphoma (NHL), a fast-growing cancer that affects B cells. Mark Roschewski, M.D., of the Lymphoid Malignancies Branch is leading CCR’s participation in a clinical trial to test the safety and effectiveness of two combination treatments to see if either combination can slow or stop the growth of lymphoma cells. Read more...

stem cell transplant

Clinical trial evaluates blood stem cell transplantation for patients with T-cell disorders

Oct 2, 2018

T cells, a type of white blood cell, develop from stem cells, mature in the thymus gland and play a key role in human immunity by protecting the body from infection. They may also help to fight cancer. People whose T cells fail to properly develop or function can develop imbalances in the immune system that lead to cancer, autoimmune disease and other problems. Jennifer Kanakry, M.D., of the Experimental Transplantation and Immunology Branch is leading a study that transplants allogeneic blood-forming stem cells from healthy donors into patients with T-cell disorders. Read more...

Mai in Afghanistan receiving the Bronze Star from Lieutenant General Michael Williamson

Former world-class hammer thrower battles diffuse large B-cell lymphoma (DLBCL)

Sep 28, 2018

In August of 2013, eight months into his volunteer deployment in Afghanistan, Michael Mai noticed a small lump between his neck and shoulder. The former world-class hammer thrower initially brushed it off as nothing but was later diagnosed with diffuse large B-cell lymphoma (DLBCL). Mai came to NIH and received treatment from Mark Roschewski, M.D., Clinical Director of the Lymphoid Malignancies Branch, that ultimately cleared him of the disease. Read more...

Multiple myeloma

Early-phase clinical trial to test new CAR T-cell therapy for multiple myeloma

Sep 18, 2018

Center for Cancer Research investigators led by James Kochenderfer, M.D., of the Experimental Transplantation and Immunology Branch, are conducting a clinical trial to test a new chimeric antigen receptor (CAR) T-cell therapy in patients whose multiple myeloma has persisted or relapsed despite standard therapy. Their goal is to develop a CAR T-cell therapy that provides lasting remission of a disease that remains highly resistant to current treatments. Read more...