Nanoparticles in the brain

Clinical trial studies antitumor effect of sunitinib in central nervous system sarcomas

Feb 4, 2019

A new clinical trial is testing a cancer drug, sunitinib, on recurrent gliosarcoma and previously treated sarcomas of the central nervous system. This drug has been studied in several other types of cancer, where it was able to inhibit factors that help tumors grow and spread. Investigators want to see if sunitinib can have the same antitumor effect on sarcomas and gliosarcoma of the brain and spinal cord. Read more...

T cells

Clinical trial finds combination therapy effective for some biliary cancer patients

Jan 28, 2019

Completion of a phase I/II clinical trial found that two of 20 patients with biliary tract cancer disease experienced a partial response to treatment with the immune checkpoint inhibitor tremelimumab combined with microwave ablation therapy. Further studies are needed to understand why just a few patients responded well to this combination treatment. Read more...

Jeremy Davis

New imaging technology to detect early-stage hereditary diffuse gastric cancer tested in clinical trial

Jan 24, 2019

Hereditary diffuse gastric cancer is a rare inherited condition caused by a mutation in the CDH1 gene. People who carry this genetic mutation are urged to have a screening endoscopy followed by surgery to remove the stomach. However, some patients elect to have regular endoscopic screenings to look for cancer. A new clinical trial is testing an imaging technology called confocal endoscopic microscopy (CEM) that may better detect cells in patients with the CDH1 mutation and potentially make a diagnosis during the endoscopy itself. Read more...

KRAS structure

Clinical trials evaluate T-cell transfer therapy for cancers with a mutated KRAS gene

Dec 17, 2018

KRAS mutations are present in up to a quarter of all human cancers, and eligible patients in a new clinical trial will undergo gene transfer therapy that uses their own blood cells. Investigators want to see if anti-KRAS T cells can make tumors shrink and whether this therapy has tolerable side effects.  Read more...

Boy playing with cars

Clinical trial studies new therapy in children and adults with neurofibromatosis-related GIST

Nov 28, 2018

Patients with neurofibromatosis type 1 (NF1) have an increased risk of developing gastrointestinal stromal tumors (GIST). There is currently no effective medical therapy for GIST that cannot be completely resected. Brigitte Widemann, M.D., Chief of the Pediatric Oncology Branch, is leading a study to see if NF1-related GIST responds to treatment with selumetinib, which blocks a signaling protein called MEK. Read more...

HPV oncogene

New immunotherapy clinical trial tests therapy for recurrent respiratory papillomatosis

Nov 23, 2018

Recurrent respiratory papillomatosis (RRP) is a rare disease caused by infection with human papillomavirus (HPV). The tumors vary in size, grow very quickly and may grow back after they have been removed, meaning patients often need to have multiple surgeries. Christian Hinrichs, M.D., of the Experimental Transplantation and Immunology Branch is leading a trial of an experimental immunotherapy drug called M7824 in patients with recurring RRP. Read more...

Polyploid giant cancer cell

Clinical trial tests safety and dosing of NEO-201 antibody in patients with advanced cancer

Nov 20, 2018

A new treatment for advanced solid tumors will use a preparation derived from human tumor tissue, NEO-201, bound to a modified version of carcinoembryonic antigen-related cell adhesion molecules that block immune cells such as T cells and natural killer cells from attacking tumors. NEO-201 also helps to bring certain immune cells to the tumor, increasing their natural function of attacking cancer cells.  Read more...

Ovarian cancer

Clinical trial tests customized treatment for ovarian cancer and peritoneal mesothelioma

Nov 15, 2018

Ovarian cancer includes cancer of the ovaries, fallopian tubes or abdominal lining (peritoneum). Peritoneal mesothelioma is a type of cancer that affects the peritoneum and is caused by ingesting asbestos fibers. In a new clinical trial, a drug derived from the patient’s own white blood cells will be customized and infused back into the patient’s body to try and combat cancer cells. Read more...

Mesothelioma Spheroid

Clinical trial tests combination therapy for malignant mesothelioma

Nov 13, 2018

Mesothelioma develops in the thin layer of tissue lining the chest or abdomen, often following exposure to airborne asbestos particles. In this study, patients will receive a combination of a targeted immunotherapy and an immunotherapy agent that blocks a protein pathway that allows cancer cells to hide from the immune system. Investigators aim to see how well patients with mesothelioma respond to this treatment.  Read more...

Renal cell carcinoma

Clinical trial evaluates small molecule inhibitor in von Hippel-Lindau disease-associated renal cell carcinoma

Oct 26, 2018

Von Hippel-Lindau (VHL) disease is a hereditary condition that causes an increased risk of developing tumors in several organs, including the kidneys. A new clinical trial is testing a small molecule inhibitor drug to see if it can suppress specific protein activity and thus shrink renal cell carcinoma tumors. Read more...

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