anatomy of the pancreas

Clinical trial studies immunotherapy and radiation for pancreatic cancer

Jun 9, 2021

Fewer than 10 percent of people with pancreatic cancer can have surgery, which offers the best chance of a cure. Udo Rudloff, M.D., Ph.D., Senior Investigator in the Pediatric Oncology Branch, is leading a study testing a combination of immunotherapy and radiation for people with advanced pancreatic cancer to shrink tumors and make surgery possible.Read more...

Jennifer N. Brudno, Lekha Mikkilineni and Stephanie L Goff

A conversation with CCR immunotherapy experts

Jun 4, 2021

June is Immunotherapy Awareness Month. We asked members of the Surgery Branch about their work with immunotherapy as they continue to make important advances in this growing field. Read more...

A nurse wearing blue gloves administers a vaccine (vaccination) into a male patient's arm.

Clinical trial evaluates COVID-19 vaccine in adults in treatment for cancer

Apr 27, 2021

Adults with hematologic malignancies or solid tumors may be eligible to participate in a new clinical trial at the NIH Clinical Center. Elad Sharon, M.D., M.P.H., Senior Investigator at the National Cancer Institute, is leading a study to assess the effects of the Moderna COVID-19 vaccine (mRNA-1273) in adults undergoing treatment for various types of cancer. Read more...

Brad Wood and Peter Pinto

Personalized approach to prostate cancer diagnosis could mean less invasive biopsies

Apr 26, 2021

Systematic and MRI-guided biopsies can each find cancers that the other technique can miss — but not everyone needs both. According to a new analysis, magnetic resonance imaging can be used to determine which biopsy approach is appropriate for an individual. Read more...

Patient, Phineas

Stem cell transplant after CAR T-cell therapy effective for young leukemia patients

Apr 20, 2021

In a clinical trial, CCR physician-scientists found that long-term survival for young patients with B-cell acute lymphoblastic leukemia was significantly better for those who received CD19-CAR T-cell therapy followed by a stem cell transplant. As a result of these findings, use of stem cell transplant is now recommended following CAR T-cell therapy. Read more...

Manufactured CAR T cells ready for infusion into a patient

FDA approves BCMA-targeted CAR T-cell therapy for multiple myeloma

Apr 15, 2021

The Food and Drug Administration approved idecabtagene vicleucel (Abecma) for people with multiple myeloma that has not responded to or has returned after at least four different prior cancer treatments. The approval is based, in part, on earlier clinical work led by James N. Kochenderfer, M.D., Senior Investigator in the Surgery Branch. Read more...

Dr. Brigitte Widemann

Brigitte Widemann named a Top Ten Clinical Research Achievement Awardee

Mar 31, 2021

Brigitte C. Widemann, M.D., Chief of the Pediatric Oncology Branch, has been named a Top Ten Clinical Research Achievement Awardee by the Clinical Research Forum, and she was awarded a Distinguished Clinical Research Achievement Award for her study “Selumetinib in Children with Inoperable Plexiform Neurofibromas.” Read more...

Respiratory System Anatomy

FDA grants orphan drug designation to PRGN-2012 for recurrent respiratory papillomatosis

Mar 30, 2021

The Food and Drug Administration has granted orphan drug designation to PRGN-2012 immunotherapy for use in patients with recurrent respiratory papillomatosis. Read more...

High magnification micrograph of a clear cell renal cell carcinoma

Combination therapy in patients with advanced kidney cancer found to be highly effective

Mar 26, 2021

A phase III international clinical trial that tested the combination therapy of nivolumab and cabozantinib in patients with advanced, untreated renal-cell carcinoma yielded promising results. Read more...

HPV-16 E5 Oncoprotein

Clinical trial investigates vaccine to treat recurrent respiratory papillomatosis after surgery

Mar 24, 2021

Scott M. Norberg, D.O., Assistant Research Physician in the Genitourinary Malignancies Branch, is leading a study of PRGN-2012, an experimental therapeutic vaccine for adults with recurrent respiratory papillomatosis (RRP). RRP is a rare disorder caused by human papillomavirus. Read more...