Travis and Dr. Widemann

CCR researchers show selumetinib shrinks tumors in children with NF1

Mar 19, 2020

Findings from a phase 2 clinical trial show that the drug selumetinib improves outcomes for children with the genetic disorder neurofibromatosis type 1 (NF1). In the trial, selumetinib shrank the inoperable tumors that develop with NF1 called plexiform neurofibromas, and children experienced reduced pain, improved function, and better overall quality of life after receiving the treatment. This trial was led by Brigitte Widemann, M.D., Chief of the Pediatric Oncology Branch (POB), and Andrea M. Gross, M.D., Assistant Research Physician in POB, and the results were published March 18, 2020, in the New England Journal of Medicine. Read more...

Milestones cover

New Milestones publication now available

Mar 12, 2020

Every year, the Center for Cancer Research makes remarkable contributions to the understanding, detection, treatment and prevention of cancer. This issue of our annual publication, Milestonesfeatures some of the most impactful science conducted in the past year in CCR. These advances include new insights into how genomes are organized and how DNA and RNA function in cells, how cellular processes and signaling events function in healthy cells and how they are affected in cancer. Other major discoveries this year include how cancers become metastatic and what drives the proliferation of cancer cells. Read more...

Peter Pinto and Pete Choyke

CCR researchers show testing with combined biopsy method improves prostate cancer diagnosis

Mar 5, 2020

A method of testing for prostate cancer developed at the Center for Cancer Research leads to more accurate diagnosis and prediction of the course of the disease, according to a new study published in the New England Journal of MedicinePeter Pinto, M.D., Investigator in the Urologic Oncology Branch, led the study and says this method, which combines systematic biopsy, the current primary diagnostic approach, with MRI-targeted biopsy, is poised to greatly improve prostate cancer diagnosis, thereby reducing the risk of both overtreatment and undertreatment of the disease. To see all open prostate cancer trials, click here. Read more...

Pancreas anatomy

Clinical trial studies combination therapy for mesothelin-expressing solid tumors

Mar 3, 2020

A clinical trial at the NIH Clinical Center is evaluating a combination therapy for mesothelin-expressing solid tumors. Mesothelin is a protein found on the surface of certain types of normal cells and cancer cells. This trial is studying the effect of LMB-100, a man-made protein attracted to mesothelin, with a drug commonly used to treat certain types of arthritis and colitis. Read more...

CAR T-cell therapy

Jennifer Brudno and James Kochenderfer discuss reduced side effects of remodeled CAR T-cell therapy

Feb 20, 2020

Jennifer Brudno, M.D., Assistant Research Physician, and James Kochenderfer, M.D., Investigator, both of the Surgery Branch, discussed their ongoing work to remodel CAR T cells to create a safer, more effective therapy in a recent Cancer Currents blog post. They share that since they tweaked the design of their original CAR T cells, the new therapy caused far fewer neurologic side effects than the original therapy did in an earlier trial but was equally effective.  Read more...

James Kochenderfer

James N. Kochenderfer receives Top Ten Clinical Research Achievement Award

Feb 3, 2020

James N. Kochenderfer, M.D., Investigator in the Surgery Branch, has been named a Top Ten Clinical Research Achievement Awardee by the Clinical Research Forum. Dr. Kochenderfer received the award for “Development of CAR T-Cell Therapy for Myeloma.” Read more...

Bladder cancer scan

Clinical trial tests combination immunotherapy for genitourinary tumors

Jan 29, 2020

Andrea B. Apolo, M.D., of the Genitourinary Malignancies Branch, is leading a study to recruit patients with each of the nearly 40 rare genitourinary malignancies and treat them with a combination of chemotherapy and immunotherapy drugs.  Read more...

CAR T-cell therapy

Side effects of CAR T-cell therapy are dramatically reduced with new receptor

Jan 22, 2020

A new immunotherapy for lymphoma has been found to cause lower levels of neurologic toxicity than other T-cell therapies for lymphoma. The findings come from the first clinical test of a CAR T-cell therapy using a new anti-cancer T-cell receptor developed in the Center for Cancer Research. Read more...

lung cancer metastasis

Now recruiting: Combination therapy clinical trial for small-cell lung or small-cell extrapulmonary cancers

Jan 16, 2020

Anish Thomas, M.D., of the Developmental Therapeutics Branch, is leading a study of a drug combination to treat small-cell lung cancer that has come back after treatment as well as small-cell cancer that started at a site other than the lungs (extrapulmonary). Small-cell lung cancer is an aggressive, fast-growing type of lung cancer. Read more...

Marijo Bilusic

Clinical trial investigates IV administration of vaccine for advanced solid tumors

Jan 14, 2020

Marijo Bilusic, M.D., Ph.D., of the Genitourinary Malignancies Branch, is leading a clinical trial to test whether giving the MVA-BN-brachyury vaccine intravenously is safe for humans and has no intolerable side effects. The goal of the study is to see whether intravenous MVA-BN-brachyury vaccine can shrink tumors and slow or prevent the spread of cancer to other parts of the body. Read more...