Doctor speaking with patient. Image credit: Canva
Gastrointestinal neuroendocrine tumors (GI NETs) are a type of cancer that affects the stomach and intestines; pheochromocytoma/paragangliomas (PPGL) are tumors that grow in or near the adrenal glands. Both of these types of tumors have high levels of proteins called somatostatin receptors (SSTR) on their surfaces. Researchers want to test a treatment that targets SSTR.
A clinical trial led by Frank I. Lin, M.D., Lasker Clinical Research Scholar in the Molecular Imaging Branch, is researching the drug [212Pb]VMT-alpha-NET for adults with gastrointestinal neuroendocrine tumors and pheochromocytoma/paragangliomas.
The trial will take place at the NIH Clinical Center in Bethesda, Maryland, and there is no cost for medical care received at the Clinical Center.
For more information, please contact the NCI Cancer Information Service at 1-888-624-1937 or nciinfo@mail.nih.gov
Clinicaltrials.gov identifier: NCT06427798
NCI Protocol ID: IRB001711
Official Title: Phase I/II Trial of Systemic Targeted Radioligand Therapy (TRT) With Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR Positive (SSTR+) Gastrointestinal (GI) Neuroendocrine Tumors (NET) and Pheochromocytoma/Paragangliomas Previously Treated With Systemic Radioligand Therapy
The Center for Cancer Research is NCI’s internal cancer center, a publicly funded organization working to improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care. Highly trained physician-scientists develop and carry out clinical trials to create the medicines of tomorrow treating patients at the world’s largest dedicated research hospital on the campus of the National Institutes of Health in Bethesda, Maryland.
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