Frank I. Lin, M.D.

Frank I. Lin, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Molecular Imaging Branch


Dr. Lin is a board-certified physician in the fields of medical oncology and nuclear medicine. Dr. Lin's research interest is in the use of systemic, targeted radionuclides or conjugates as a treatment modality for cancer, and he is head of the Targeted Radionuclide Therapy Section of the Molecular Imaging Branch at NCI. Selected as a Lasker Clinical Research Scholar in 2016, Dr. Lin leads several pre-clinical investigations of radionuclide therapy agents as well as being the principal or associate investigator on a number of clinical trials at the NIH involving radionuclide therapy. Dr. Lin is particularly interested in the development and clinical translation of novel alpha particle and Auger electron-emitting radionuclides as targeted therapy for cancer.

Areas of Expertise

Targeted Radionuclide Therapy
Alpha Particle-Emitting Radionuclides
Nuclear Medicine
Positron Emission Tomography (PET)

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Recent Publications

Continuing Medical Education: Systemic Radionuclide Therapy of Pheochromocytoma/Paraganglioma

Carrasquillo J, et al. [Senior author]
Journal of Nuclear Medicine and Molecular Imaging . [ Journal Article ]

In vitro and in vivo comparison of 3,2-HOPO versus DFO-based chelation of zirconium-89 to the anti-mesothelin antibody anetumab

Roy J, et al. [Senior author]
Cancer Biotherapy and Radiopharmaceuticals . 2017. [ Journal Article ]

Utility of 18F-fluoroestradiol (18F-FES) PET/CT imaging as a pharmacodynamic marker in patients with refractory estrogen receptor-positive solid tumors receiving Z-endoxifen therapy

Lin FI., Mena E., Lindenberg L., Adler S., Ton A., et al
Eur J Nucl Med Mol Imaging. 44(3): 500-508, 2017. [ Journal Article ]

Case Report: Primary Hypothyroidism Associated with Lutetium 177-DOTATATE Therapy for Metastatic Paraganglioma

Gubbi S, et al. [Senior author]
Frontiers in Endocrinology-Cancer Endocrinology. Jan 12: 2021. [ Journal Article ]

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Jyoti Roy, Ph.D.
Jyoti Roy, Ph.D.
Research Fellow/ Visiting Fellow


Postdoctoral Fellow (Visiting)
Bruna Fernandes, Ph.D.