Pancreatic cancer cells

New clinical trial explores precision treatment for advanced pancreatic cancer

Posted: Nov 7, 2017

A new phase II clinical trial to assess the safety and efficacy of a drug called selumetinib for treating patients with advanced pancreatic cancer whose tumors harbor a specific genetic marker has opened at the Center for Cancer Research and is currently recruiting participants. Read more...

New clinical trial explores precision treatment for advanced pancreatic cancer
Lymphoma cells

New clinical trial explores targeted therapy for three types of rare and aggressive lymphoma

Posted: Nov 3, 2017

Gray-zone lymphoma, central nervous system lymphoma and extra-nodal diffuse large B-cell lymphomas are often resistant to treatment with radiation and standard chemotherapy. Mark Roschewski, M.D., of the Lymphoid Malignancies Branch, is leading a study to determine if pembrolizumab can improve outcomes for patients with certain rare lymphomas. Read more... 

New clinical trial explores targeted therapy for three types of rare and aggressive lymphoma
Lung cancer cells

Combination therapy for advanced or metastatic non-small cell lung cancer will be tested in new clinical trial

Posted: Nov 1, 2017

Non-small cell lung cancer (NSCLC) develops when abnormal lung cells begin to grow out of control. These cells can form into a tumor and spread to other areas of the body. David Schrump, M.D., of the Thoracic and Gastrointestinal Oncology Branch is leading a clinical trial of a new combination treatment for patients with advanced or metastatic NSCLC that cannot be treated surgically. Read more... 

Combination therapy for advanced or metastatic non-small cell lung cancer will be tested in new clinical trial
Pepe Bryan

CCR clinical trial opens new door for pediatric cancer patient

Posted: Oct 30, 2017

When standard treatment for adult T-cell leukemia/lymphoma (ATLL) proved ineffective, Pepe Bryan and his family traveled from their home in Kingston, Jamaica, to participate in a clinical trial at the NIH Clinical Center led by Kevin Conlon, M.D., of the Lymphoid Malignancies Branch. ATLL is a rare and aggressive type of blood cancer that affects the immune system’s T cells. While receiving treatment at the Clinical Center, Pepe stayed at the Children’s Inn — a temporary residence on the NIH campus for families with children participating in clinical trials. As Pepe’s fight against cancer continues, his demeanor remains positive and hopeful. “The NIH means life to me. And The Children’s Inn is a great place. Let me tell you, it’s wonderful. They give you food and housing, and they take you on outings and activities. It’s wonderful!” Read more about Pepe's story…

CCR clinical trial opens new door for pediatric cancer patient
human brain with metastases of breast cancer

New clinical trial aims to prevent breast cancer from recurring in the brain

Posted: Oct 27, 2017

In some types of breast cancer, the tumor cells spread more frequently to the brain. A new clinical trial run by CCR investigators will test whether a drug called temozolomide can prevent these deadly lesions from recurring. Read more... 

New clinical trial aims to prevent breast cancer from recurring in the brain

Combination therapy clinical trial now recruiting patients with metastatic colorectal cancer

Posted: Sep 20, 2017

A new clinical trial tests an approach that may boost the immune system’s ability to attack tumor cells for colorectal cancer that has not responded to other therapies. Read more...

Combination therapy clinical trial now recruiting patients with metastatic colorectal cancer

Clinical trial looks at new methods of assessing treatment response for esophageal cancer

Posted: Sep 12, 2017

Currently, there is no way to accurately evaluate patients' response to treatment or to detect residual esophageal cancer without removing the esophagus. R. Taylor Ripley, M.D., of the Thoracic and Gastrointestinal Oncology Branch is leading a study to determine whether metabolomic signatures or BH3 profiling in biopsy tissues can identify patients who will likely respond well to pre-surgical treatment.  Learn more...

Clinical trial looks at new methods of assessing treatment response for esophageal cancer

Clinical trial will investigate targeted radionuclide therapy for inoperable rare tumors

Posted: Aug 29, 2017

In an upcoming phase II clinical trial, Center for Cancer Research investigators will explore the ability of a targeted radioactive drug to treat inoperable pheochromocytoma and paraganglioma, both rare tumors.  Learn more...

Clinical trial will investigate targeted radionuclide therapy for inoperable rare tumors

Clinical trial aims to study immunotherapy for central nervous system tumors

Posted: Aug 23, 2017

A new clinical trial aims to determine whether nivolumab, an immune checkpoint inhibitor, can improve control of cancer for patients with several types of tumors of the central nervous system (CNS). The CNS is composed of the brain and spinal cord and the cause of most CNS tumors in adults is unknown. Learn more...

Clinical trial aims to study immunotherapy for central nervous system tumors

Clinical trial tests drug for tumors associated with Krebs-cycle dysfunction

Posted: Aug 15, 2017

The Krebs cycle is part of the complex process where cells turn food into energy. One of the elements of the Krebs cycle is succinate dehydrogenase (SDH). Loss of SDH activity in cells has been linked to tumor formation. This new trial is studying guadecitabine for tumors associated with Krebs cycle dysfunction. Learn more...

Clinical trial tests drug for tumors associated with Krebs-cycle dysfunction

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