Doctor speaking with patient. Image credit: Canva
ANK-101 is an anchored IL-12 immunotherapy designed for limited intratumoral delivery to increase immune cell infiltration into tumors. It may also be effective when paired with cemiplimab for certain patients.
A clinical trial led by Danielle M. Pastor, D.O., Ph.D., Assistant Research Physician in the Center for Immuno-Oncology, is researching the safety and tolerability of intratumoral injection of ANK-101 in participants with advanced solid tumors who have progressed during or after receiving standard of care therapy or who will not benefit from such therapy. Some participants will receive a combination of ANK-101 with cemiplimab.
The trial will take place at the NIH Clinical Center in Bethesda, Maryland, and there is no cost for medical care received at the Clinical Center.
For more information, please contact the NCI Cancer Information Service at 1-888-624-1937 or nciinfo@mail.nih.gov
Clinicaltrials.gov identifier: NCT06171750
NCI Protocol ID: IRB001924
Official Title: A Phase I Open-Label, Dose Escalation Study of the Safety and Tolerability of ANK-101 in Advanced Solid Tumors
The Center for Cancer Research is NCI’s internal cancer center, a publicly funded organization working to improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care. Highly trained physician-scientists develop and carry out clinical trials to create the medicines of tomorrow treating patients at the world’s largest dedicated research hospital on the campus of the National Institutes of Health in Bethesda, Maryland.
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