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Chief
Crystal L. Mackall, M.D.
Branch Email Address
ncipediatrics@mail.nih.gov

Center for Cancer Research
National Cancer Institute

Building 10, Room 1W-3750
Bethesda, MD 20892
301-496-4256

The Pediatric Oncology Branch is dedicated to improving outcomes for children and young adults with cancer and genetic tumor predisposition syndromes. We conduct translational research that spans basic science to clinical trials. Our clinical studies are performed in an environment that supports our patient’s medical and emotional needs, alongside cutting edge scientific research.

Whether you are a referring physician, family member or patient with childhood cancer or neurofibromatosis, or are interested in training at the Pediatric Oncology Branch, we hope that this website will provide the information you need to access our programs. Crystal L. Mackall MD, Chief, Pediatric Oncology Branch

Crystal L. Mackall, MD
Chief, Pediatric Oncology Branch
 
  • Refer a patientRefer a Patient

    Physicians should contact the Pediatric Oncology Branch by calling 301-496-4256  or 1-877-624-4878 (8:30 a.m. to 5:00 p.m., Monday-Friday) or email ncipediatrics@mail.nih.gov 

  • clinical trialsClinical Trials

    We conduct clinical trials in acute lymphoblastic leukemia, pediatric sarcomas, neuroblastoma, brain tumors, malignant melanoma, neurofibromatosis and Phase I trials.

  • pediatric oncology fellowshipFellowship

    The Pediatric Hematology Oncology Fellowship is a joint program of the Pediatric Oncology Branch, NCI, NIH and Johns Hopkins University.

  • Birgette WidemannAwards

    Dr. Brigitte Widemann received the prestigious Von Recklinghausen Award at the 2013 Children’s Tumor Foundation conference in Monterrey CA.

Our investigators and physicians realize that many challenges remain in the treatment of childhood cancers and genetic tumor predisposition syndromes but we are committed to improving outcomes for children and young adults with these diseases through cutting-edge basic and clinical research. Patients with cancer, neurofibromatosis type 1 (NF1), NF2 or other diseases under study who are enrolled on Branch clinical trials may receive therapy at the NIH Clinical Center.

Our clinical programs and trials span early treatment studies with new targeted agents including small molecules, monoclonal antibodies and immunotoxins, immunotherapy including tumor vaccines, and bone marrow transplantation, to studies aimed at improving our understanding of childhood cancers and the conditions that predispose children to cancer. Our multidisciplinary teams specialize in the study and treatment of:

Support Services

The treatment of a childhood cancer presents extraordinary psychological, emotional and social challenges to the entire family. We offer a variety of support services to help patients and their families adapt and mobilize resources during treatment for these diseases. At the heart of these services is the personal commitment of every clinical team member to understand each young patient as a unique individual with specific needs. Team members collaborate with parents at each step in the process to be attentive to the quality of life of all family members, including siblings.  

 

refer a patientReferrals

Physicians, patients, or family members may contact the Pediatric Oncology Branch from 8:30 AM to 5:00 PM, Monday-Friday:

 

 

camp fantasticRelated Links

 

pob traineesTraining Opportunities

 

Trainees and Featured Alumni

  • James Morrow – MD/PhD, Graduate Student
  • Adrienne Long – MD/PhD, Graduate Student
  • Meera Murgabi – PhD, Postdoctoral Fellow
  • Jerry Jaboin – MD, PhD, Assistant Professor, Radiation Oncology, Washington University, St. Louis
  • AeRang Kim – MD, PhD, Assistant Professor, George Washington University and Attending Physician at the Center for Cancer and Blood Disorders at the Children’s National Medical Center

Next Gen award presentation to Dr. Nirali Shah

NextGen Award Presented to
Dr. Nirali Shah

October 24, 2014

Dr. Nirali Shah, attending physician in the Pediatric Oncology Branch, was awarded the NextGen Award from the Children's Cancer Foundation which provides young scientists with funding for innovative research.  Dr. Shah is investigating the use of activated natural killer (NK) cells to treat cancer in the context of allogeneic stem cell transplantation.

  • Genetic Changes Mapped

    January 23, 2014

    Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. More...

  • New Treatment

    October 13, 2014

    Led by Dr. Daniel (Trey) Lee and Dr. Crystal Mcakall, investigators in the Pediatric Oncology Branch reported the results of the first intent-to-treat trial of anti-CD19 chimeric antigen receptor (CAR) modified T cells for the treatment of B cell acute lymphoblastic leukemia.  More...

  • Trees of Life

    August 22, 2013

    Annette Weller’s daughter Lauren died Dec. 14, 2011, when she was 26. She had Ewing’s sarcoma, a type of bone cancer. Weller painted a tree on a window in the pediatric unit of the National Institutes of Health Clinical Center shortly before Lauren passed away. Weller has since returned numerous times to paint more of the clinic’s windows.  More...

  • Von Recklinghausen Award

    June 13, 2013

    Dr. Brigitte Widemann received the prestigious Von Recklinghausen Award at the 2013 Children’s Tumor Foundation conference in Monterrey, CA.  The organizers cited Dr. Widemann's international leadership in the conduct of cutting-edge clinical trials for neurofibromatosis and the effectiveness with which she has worked with the preclinical consortium to drive new clinical trials in these diseases.

About

The Pediatric Oncology Branch is dedicated to improving outcomes for children and young adults with cancer and genetic tumor predisposition syndromes. We conduct translational research that spans basic science to clinical trials. Our clinical studies are performed in an environment that supports our patient’s medical and emotional needs, alongside cutting edge scientific research.

Whether you are a referring physician, family member or patient with childhood cancer or neurofibromatosis, or are interested in training at the Pediatric Oncology Branch, we hope that this website will provide the information you need to access our programs. Crystal L. Mackall MD, Chief, Pediatric Oncology Branch

Crystal L. Mackall, MD
Chief, Pediatric Oncology Branch
 
  • Refer a patientRefer a Patient

    Physicians should contact the Pediatric Oncology Branch by calling 301-496-4256  or 1-877-624-4878 (8:30 a.m. to 5:00 p.m., Monday-Friday) or email ncipediatrics@mail.nih.gov 

  • clinical trialsClinical Trials

    We conduct clinical trials in acute lymphoblastic leukemia, pediatric sarcomas, neuroblastoma, brain tumors, malignant melanoma, neurofibromatosis and Phase I trials.

  • pediatric oncology fellowshipFellowship

    The Pediatric Hematology Oncology Fellowship is a joint program of the Pediatric Oncology Branch, NCI, NIH and Johns Hopkins University.

  • Birgette WidemannAwards

    Dr. Brigitte Widemann received the prestigious Von Recklinghausen Award at the 2013 Children’s Tumor Foundation conference in Monterrey CA.

Referrals

refer a patientReferrals

Physicians, patients, or family members may contact the Pediatric Oncology Branch from 8:30 AM to 5:00 PM, Monday-Friday:

 

 

camp fantasticRelated Links

 

For Patients

Our investigators and physicians realize that many challenges remain in the treatment of childhood cancers and genetic tumor predisposition syndromes but we are committed to improving outcomes for children and young adults with these diseases through cutting-edge basic and clinical research. Patients with cancer, neurofibromatosis type 1 (NF1), NF2 or other diseases under study who are enrolled on Branch clinical trials may receive therapy at the NIH Clinical Center.

Our clinical programs and trials span early treatment studies with new targeted agents including small molecules, monoclonal antibodies and immunotoxins, immunotherapy including tumor vaccines, and bone marrow transplantation, to studies aimed at improving our understanding of childhood cancers and the conditions that predispose children to cancer. Our multidisciplinary teams specialize in the study and treatment of:

Support Services

The treatment of a childhood cancer presents extraordinary psychological, emotional and social challenges to the entire family. We offer a variety of support services to help patients and their families adapt and mobilize resources during treatment for these diseases. At the heart of these services is the personal commitment of every clinical team member to understand each young patient as a unique individual with specific needs. Team members collaborate with parents at each step in the process to be attentive to the quality of life of all family members, including siblings.  

 

Teams

For Trainees

pob traineesTraining Opportunities

 

Trainees and Featured Alumni

  • James Morrow – MD/PhD, Graduate Student
  • Adrienne Long – MD/PhD, Graduate Student
  • Meera Murgabi – PhD, Postdoctoral Fellow
  • Jerry Jaboin – MD, PhD, Assistant Professor, Radiation Oncology, Washington University, St. Louis
  • AeRang Kim – MD, PhD, Assistant Professor, George Washington University and Attending Physician at the Center for Cancer and Blood Disorders at the Children’s National Medical Center

Our Science

News

Next Gen award presentation to Dr. Nirali Shah

NextGen Award Presented to
Dr. Nirali Shah

October 24, 2014

Dr. Nirali Shah, attending physician in the Pediatric Oncology Branch, was awarded the NextGen Award from the Children's Cancer Foundation which provides young scientists with funding for innovative research.  Dr. Shah is investigating the use of activated natural killer (NK) cells to treat cancer in the context of allogeneic stem cell transplantation.

  • Genetic Changes Mapped

    January 23, 2014

    Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. More...

  • New Treatment

    October 13, 2014

    Led by Dr. Daniel (Trey) Lee and Dr. Crystal Mcakall, investigators in the Pediatric Oncology Branch reported the results of the first intent-to-treat trial of anti-CD19 chimeric antigen receptor (CAR) modified T cells for the treatment of B cell acute lymphoblastic leukemia.  More...

  • Trees of Life

    August 22, 2013

    Annette Weller’s daughter Lauren died Dec. 14, 2011, when she was 26. She had Ewing’s sarcoma, a type of bone cancer. Weller painted a tree on a window in the pediatric unit of the National Institutes of Health Clinical Center shortly before Lauren passed away. Weller has since returned numerous times to paint more of the clinic’s windows.  More...

  • Von Recklinghausen Award

    June 13, 2013

    Dr. Brigitte Widemann received the prestigious Von Recklinghausen Award at the 2013 Children’s Tumor Foundation conference in Monterrey, CA.  The organizers cited Dr. Widemann's international leadership in the conduct of cutting-edge clinical trials for neurofibromatosis and the effectiveness with which she has worked with the preclinical consortium to drive new clinical trials in these diseases.