Rosandra N. Kaplan, M.D.

Rosandra N. Kaplan, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch


Dr. Kaplan is a physician scientist who developed the concept of the pre-metastatic niche describing the changes in distant microenvironments in response to a growing tumor that create a niche environment conducive to disseminating tumor cell survival and growth resulting in clinically relevant metastasis. Dr. Kaplan has an active translational research program focusing on developing novel biomarkers and targets of the metastatic microenvironment by understanding the commonalities in mechanisms employed by a cancer cell to generate an entire heterogenous tumor at distant sites and stem cells and their niche to repopulate tissues.

Areas of Expertise

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Recent Publications

Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

Sabina Kaczanowska, Daniel W Beury, Vishaka Gopalan, Arielle K Tycko, Haiying Qin, Miranda E Clements, Justin Drake, Chiadika Nwanze, Meera Murgai, Zachary Rae, Wei Ju, Katherine A Alexander, Jessica Kline, Cristina F Contreras, Kristin M Wessel, Shil Patel, Sridhar Hannenhalli, Michael C Kelly, Rosandra N Kaplan
Cell. 2021.
Full-Text Article
[ Journal Article ]

Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I-Related Plexiform Neurofibromas

Lauren H Boal, John Glod, Melissa Spencer, Miki Kasai, Joanne Derdak, Eva Dombi, Mark Ahlman, Daniel W Beury, Melinda S Merchant, Christianne Persenaire, David J Liewehr, Seth M Steinberg, Brigitte C Widemann, Rosandra N Kaplan
Clin Cancer Res. 2020.
Full-Text Article
[ Journal Article ]

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

Meera Murgai, Wei Ju, Matthew Eason, Jessica Kline, Daniel W Beury, Sabina Kaczanowska, Markku M Miettinen, Michael Kruhlak, Haiyan Lei, Jack F Shern, Olga A Cherepanova, Gary K Owens, Rosandra N Kaplan
Nat Med. 2017.
Full-Text Article
[ Journal Article ]

Targeting tumor microenvironment and metastasis in children with solid tumors

Kristin M Wessel, Rosandra N Kaplan
Curr Opin Pediatr. 2022.
Full-Text Article
[ Journal Article ]

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Research Biologist
Wei Ju, Ph.D.
Program Assistant
Crystal Fuller
Postdoctoral Fellow
Mohit Singh, Ph.D.
Postdoctoral Fellow
Mohd Omar Sikder, Ph.D.
Postbaccalaureate Fellow
Alondra Martinez Osorno
Graduate Student
Cristie Contreras Burrola
Clinical Fellow
Jacqui Klicka-Skeels, M.D.
Clinical Fellow
James Cronk, M.D., Ph.D.
Clinical Fellow
Julia Segal, M.D.
Head shot of Etan Aber
Clinical Fellow
Etan Aber, M.D., Ph.D.
Headshot of Emily San Andres
Postbaccalaureate Fellow
Emily San Andres Montalvan, B.S.