Headshot of Dr. Kaczanowska

Sabina A. Kaczanowska, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch


Sabina Kaczanowska’s research focus is to understand the role of the immune system in shaping the microenvironment of metastasis during cancer progression. Specifically, she is investigating how myeloid cells orchestrate the immunosuppressive program in the pre-metastatic niche and how we can apply this knowledge of myeloid biology to design new immunotherapeutic strategies for the treatment of solid tumors.

Areas of Expertise

1) tumor immunology, 2) cancer immunotherapy, 3) tumor microenvironment, 4) metastasis 


Selected Key Publications

Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

Kaczanowska, S., D.W. Beury, V. Gopalan, A.K. Tycko, H. Qin, M.E. Clements, J. Drake, C. Nwanze, M. Murgai, Z. Rae, W. Ju, K.A. Alexander, J. Kline, C.F. Contreras, K.M. Wessel, S. Patel, S. Hannenhalli, M. Kelly, and R.N. Kaplan
Cell. 184: 2021. [ Journal Article ]

Considerations for treatment duration in responders to immune checkpoint inhibitors

Marron, T.U., A.E. Ryan, S.M. Reddy, S. Kaczanowska, R.H. Younis, D. Thakkar, J. Zhang, T. Bartkowiak, R. Howard, K.G. Anderson, D. Olson, A.R. Naqash, R.B. Patel, E. Sachdev, M.E. Rodríguez-Ruiz, M. Sheffer, S.E. Church, C. Fuhrman, A. Overacre-Delgoffe, R. Nguyen, V. Florou, J. Thaxton, D.H. Aggen, and J.L. Guerriero
J. Immunother. Cancer.. 2021. [ Journal Article ]

Mapping the switch that drives the pre-metastatic niche

Kaczanowska, S. and Kaplan, R.N.
Nature Cancer. 2020. [ Journal Article ]

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

Murgai, M., W. Ju, M. Eason, J. Kline, D.W. Beury, S. Kaczanowska, M.M. Miettinen, M. Kruhlak, H. Lei, J.F. Shern, O.A. Cherepanova, G.K. Owens, and R.N. Kaplan.
Nature Medicine. 23/10: 2017. [ Journal Article ]

A synthetic CD8:MyD88 co-receptor enhances CD8+ T cell responses to weakly immunogenic and lowly expressed tumor antigens

Kaczanowska, S., A.M. Joseph, J. Guo, A.K. Tsai, J.J. Lasola, K. Younger, Y. Zhang, C.V. Gonzales, and E. Davila
Cancer Research. 77/24: 2017. [ Journal Article ]