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Jessica A. Lake, M.D., M.P.H.

  • Center for Cancer Research
  • National Cancer Institute
Assistant Research Physician
Pediatric Oncology Branch

RESEARCH SUMMARY

Jessica Lake is a physician scientist with clinical and research interests focused on improving cellular/immunotherapy for the treatment of pediatric solid tumors. She is interested in the design and conduct of clinical trials that take insights from solid tumor biology and tumor microenvironment research and translate that knowledge into novel and innovative therapies for solid tumor patients.

Areas of Expertise

Solid Tumors
Immunotherapy
Cellular Therapy
Clinical Trial Design

Information for Patients

Learn more about our clinical trials and the highly specialized care teams who lead them.

Publications

Selected Recent Publications

Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma

Jessica A Lake, Elena Woods, Eric Hoffmeyer, Kristin L Schaller, Joselyn Cruz-Cruz, Joseph Fernandez, Dejene Tufa, Benjamin Kooiman, Spencer C Hall, Dallas Jones, Masanori Hayashi, Michael R Verneris
Journal for Immunotherapy of Cancer. 2024.
Full-Text Article
[ Journal Article ]

Targeting osteosarcoma with canine B7-H3 CAR T cells and impact of CXCR2 Co-expression on functional activity

Jennifer W Cao, Jessica Lake, Renata Impastato, Lyndah Chow, Luisanny Perez, Laura Chubb, Jade Kurihara, Michael R Verneris, Steven Dow
Cancer Immunology, Immunotherapy. 2024.
Full-Text Article
[ Journal Article ]

Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors.

Jessica A Lake, Andrew M Donson, Eric Prince, Kurtis D Davies, Anandani Nellan, Adam L Green, Jean Mulcahy Levy, Kathleen Dorris, Rajeev Vibhakar, Todd C Hankinson, Nicholas K Foreman, Mark D Ewalt, Bette K Kleinschmidt-DeMasters, Lindsey M Hoffman, Ahmed Gilani
Pediatr Blood Cancer. 2020.
Full-Text Article

Targetable molecular alterations in congenital glioblastoma.

Ahmed Gilani, Andrew Donson, Kurtis D Davies, Susan L Whiteway, Jessica Lake, John DeSisto, Lindsey Hoffman, Nicholas K Foreman, B K Kleinschmidt-DeMasters, Adam L Green
J Neurooncol. 2020.
Full-Text Article
[ Journal Article ]