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Dr. Jackson's headshot.

Sadhana Jackson, M.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10, Room 7D45
  • Bethesda, MD 20892
  • 301-594-7037
Pediatric Oncology Branch

RESEARCH SUMMARY

Dr. Jackson’s research interests center on evaluating the blood-brain barrier (BBB) of malignant gliomas.  Her clinical and translational research focuses on transiently disrupting the BBB by pharmacologic means, in an effort to improve cytotoxic therapy to the central nervous system.  She uses brain microdialysis, pharmacokinetic analysis, and preclinical models to study central nervous system (CNS) pharmacology. Dr. Jackson also leads collaborative preclinical and clinical studies focused on understanding BBB integrity in normal brain and malignant gliomas with the goal of developing novel treatment strategies for brain tumor patients.

Dr. Jackson is a Pediatric Neuro-oncologist and an Adjunct Investigator in CCR's Pediatric Oncology Branch.

Areas of Expertise

1) neuro-oncology 2) blood-brain barrier 3) drug delivery 4) pharmacokinetics 5) malignant brain tumors

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.

Publications

Selected Recent Publications

The effect of an adenosine A(2A) agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma

Jackson S, Weingart J, Nduom EK, Harfi TT, George RT, McAreavey D, Ye X, Anders NM, Peer C, Figg WD, Gilbert M, Rudek MA, Grossman SA.
Fluids Barriers CNS. 15(1): 2, 2018. [ Journal Article ]

The effect of regadenoson on the integrity of the human blood-brain barrier, a pilot study

Jackson S, George RT, Lodge MA, Piotrowski A, Wahl RL, Gujar SK, Grossman SA.
J Neurooncol. 132(3): 513-519, 2017. [ Journal Article ]

Targeting WNT Signaling for Multifaceted Glioblastoma Therapy

McCord M, Mukouyama YS, Gilbert MR, Jackson S.
Front Cell Neurosci. 11: 318, 2017. [ Journal Article ]

SNO 2020 diversity survey: defining demographics, racial biases, career success metrics and a path forward for the field of neuro-oncology

Ugonma N Chukwueke 1, Elizabeth Vera 2, Alvina Acquaye 2, Shawn L Hervey-Jumper 3 4, Yazmin Odia 4, Laura J Klesse 5, Erin Dunbar 6, Akanksha Sharma 7, Ekokobe Fonkem 8, Alissa A Thomas 9, Tamra E Werbowetski-Ogilvie 10, Sandra Camelo-Piragua 11, Na Tosha N Gatson 12, Macarena I de la Fuente 13, Terri S Armstrong 2, Alyx B Porter 14, Sadhana Jackson 15
SNO 2020 diversity survey: defining demographics, racial biases, career success metrics and a path forward for the field of neuro-oncology. 2021.
Full-Text Article
[ Journal Article ]

High-risk Medulloblastoma-Balancing the High Stakes of Molecular Profiling to Enhance Treatment Responsivity

Allison M Martin 1, Sadhana Jackson 2 3
JAMA Oncology. 2021.
Full-Text Article
[ Journal Article ]

Team

Biologist
Nabanita Kundu, PhD
Animal Biologist
Sanghee Lim, MS
Post-Doctorate Fellow
Christina Conrad, PhD
Post-baccalaureate fellow
Mahalia Dalmage, BS
Melissa Cesaire

Alumni

Amelie Vezina, MS, PhD
Amelie Vezina
Post-Doctoral Fellow
Dr. Matthew McCord, MD
Matthew McCord
Medical Student Research Program Fellow
Brandon Foster
Brandon Foster
Post-baccalaureate Research Fellow
Caitlin Meeks
Caitlin Meeks