Udo  Rudloff, M.D., Ph.D.

Udo Rudloff, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10 - Hatfield CRC, Room 4-3740
  • Bethesda, MD 20892
  • 240-760-6238
  • 301-451-6933
Pediatric Oncology Branch


Dr. Rudloff’s laboratory and clinical work is focused on the discovery, translation, and early phase clinical testing of novel therapies for patients afflicted by pancreas and other solid organ cancers. His laboratory has built a program that discovers new leads for future cancer therapies from phenotype-directed drug screening. The best candidates with regard to (1) targeting essential cellular phenotypes of cancer, (2) chemotypes with favorable pharmaco- and toxicokinetic properties, and (3) a fully understood mechanism of action to facilitate future biomarker development and design of combination studies are selected as preclinical development candidates and moved into IND-enabling studies. His recent work includes the development and clinical translation of metarrestin, a small molecule for the treatment of cancer metastasis, which targets nucleolar genome organization of cancer cells, and a series of first-in-class small molecule-, peptide-, and nanobody-based innate defense modulators targeting CD206high tumor-associated macrophages for improved cancer immunotherapy.

Areas of Expertise

Preclinical Drug Development and Early Phase Clinical Testing
Pharmaco- and Toxicokinetics

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 

Clinical Trials


Selected Recent Publications

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Jaynes JM, Sable R, Ronzetti M, Bautista W, Knotts Z, Abisoye-Ogunniyan A, Li D, Calvo R, Dashnyam M, Singh A, Guerin T, White J, Ravichandran S, Kumar P, Talsania K, Chen V, Ghebremedhin A, Karanam B, Bin Salam A, Amin R, Odzorig T, Aiken T, Nguyen V, Bian Y, Zarif JC, de Groot AE, Mehta M, Fan L, Hu X, Simeonov A, Pate N, Abu-Asab M, Ferrer M, Southall N, Ock CY, Zhao Y, Lopez H, Kozlov S, de Val N, Yates CC, Baljinnyam B, Marugan J, Rudloff U.
Sci Transl Med. 12(530): eaax6337, 2020. [ Journal Article ]

The Changing Paradigm of Management of Liver Abscesses in Chronic Granulomatous Disease

Straughan DM, McLoughlin KC, Mullinax JE, Marciano BE, Freeman AF, Anderson VL, Uzel G, Azoury SC, Sorber R, Quadri HS, Malech HL, DeRavin SS, Kamal N, Koh C, Zerbe CS, Kuhns DB, Gallin JI, Heller T, Holland SM, Rudloff U.
Clin Infect Dis. 66(9): 1427-34, 2018. [ Journal Article ]

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype

Bian Y, Teper Y, Mathews Griner LA, Aiken TJ, Shukla V, Guha R, Shinn P, Xin HW, Pflicke H, Powers AS, Li D, Jiang JK, Patel P, Rogers SA, Aubé J, Ferrer M, Thomas CJ, Rudloff U.
Mol Cancer Ther. 18(11): 2097-2110, 2019. [ Journal Article ]

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer and other less common disease histologies: is it time?

Feingold PL, Kwong ML, Sabesan A, Sorber R, Rudloff U.
J Gastrointest Oncol. 7(1): 87-98, 2016. [ Journal Article ]

Job Vacancies

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Postdoctoral Fellow (Visiting)
Sitanshu Singh, PhD
Postdoctoral Fellow (Visiting)
Soumita De, Ph.D.
Research Fellow
Rushikesh Sable, Ph.D.
Postdoctoral Fellow (Visiting)
Saifun Nahar, Ph.D.
Postdoctoral Fellow (Visiting)
Anju Kumari, Ph.D.