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Naomi Taylor

Naomi Taylor, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch

RESEARCH SUMMARY

Our group uses multidisciplinary approaches to advance fundamental and translational research axes:

  • Elucidating the metabolic programs regulating T cell differentiation and anti-tumor effector responses
  • Mechanistic evaluations of immune cell function to develop of novel immunotherapy strategies – including chimeric antigen receptor (CAR) T cells – for the treatment of patients with pediatric cancers and immunodeficiencies
  • Determining the impact of metabolic parameters on hematopoietic stem cell (HSC) differentiation, with a focus on normal and pathological erythropoiesis and lymphopoiesis   
  • Understanding the crosstalk between tumor growth and the bone marrow microenvironment

Areas of Expertise

Hemato-Metabolism
Thymocyte Differentiation
Gene Therapy

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 

Publications

Selected Key Publications

Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A. Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A

Pedro Gonzalez-Menendez, Ira Phadke, Meagan E Olive, Axel Joly, Julien Papoin, Hongxia Yan, Jérémy Galtier, Jessica Platon, Sun Woo Sophie Kang, Kathy L McGraw, Marie Daumur, Marie Pouzolles, Taisuke Kondo, Stéphanie Boireau, Franciane Paul, David J Young, Sylvain Lamure, Raghavendra G Mirmira, Anupama Narla, Guillaume Cartron, Cynthia E Dunbar, Myriam Boyer-Clavel, Natalie Porat-Shliom, Valérie Dardalhon, Valérie S Zimmermann, Marc Sitbon, Thomas E Dever, Narla Mohandas, Lydie Da Costa, Namrata D Udeshi, Lionel Blanc, Sandrina Kinet, Naomi Taylor
Blood. 2023.
Full-Text Article
[ Journal Article ]

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Haneen Shalabi, Haiying Qin, Angela Su, Bonnie Yates, Pamela L Wolters, Seth M Steinberg, John A Ligon, Sara Silbert, Kniya DéDé, Mehdi Benzaoui, Sophia Goldberg, Sooraj Achar, Dina Schneider, Shilpa A Shahani, Lauren Little, Toni Foley, John C Molina, Sandhya Panch, Crystal L Mackall, Daniel W Lee, Christopher D Chien, Marie Pouzolles, Mark Ahlman, Constance M Yuan, Hao-Wei Wang, Yanyu Wang, Jon Inglefield, Mary Anne Toledo-Tamula, Staci Martin, Steven L Highfill, Gregoire Altan-Bonnet, David Stroncek, Terry J Fry, Naomi Taylor, Nirali N Shah
Blood. 2022.
Full-Text Article
[ Journal Article ]

Entry of glucose and glutamine carbons into the citric acid cycle supports early steps in HIV-1 infection in CD4 T cells

Isabelle Clerc, Daouda Abba Moussa, Zoi Vahlas, Saverio Tardito, Leal Oburoglu, Thomas J Hope, Marc Sitbon, Valérie Dardalhon, Cédric Mongellaz, Naomi Taylor
Nat Metab. 2019.
Full-Text Article
[ Journal Article ]

A glutamine-α-ketoglutarate metabolic switch regulates the balance between T helper 1 and regulatory T cell fates

Dorota Klysz, Xuguang Tai, Philippe A Robert, Marco Craveiro, Gaspard Cretenet, Leal Oburoglu, Cédric Mongellaz, Stefan Floess, Vanessa Fritz, Maria I Matias, Carmen Yong, Natalie Surh, Julien C Marie, Jochen Huehn, Valérie Zimmermann, Sandrina Kinet, Valérie Dardalhon, Naomi Taylor
Sci Signal. 2015.
Full-Text Article
[ Journal Article ]

Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification

Leal Oburoglu, Saverio Tardito, Vanessa Fritz, Stéphanie C de Barros, Peggy Merida, Marco Craveiro, João Mamede, Gaspard Cretenet, Cédric Mongellaz, Xiuli An, Dorota Klysz, Jawida Touhami, Myriam Boyer-Clavel, Jean-Luc Battini, Valérie Dardalhon, Valérie S Zimmermann, Narla Mohandas, Eyal Gottlieb, Marc Sitbon, Sandrina Kinet, Naomi Taylor
Cell Stem Cell. 2014.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Team

Headshot of Chris Chien
Biologist
Christopher D. Chien, Ph.D.
Headshot of Taisuke
Postdoctoral Fellow
Taisuke Kondo, Ph.D.
Postdoctoral Fellow
Josquin Moraly, M.S., M.D.
Headshot of Lynn Fu
Postbaccalaureate Fellow
Lynn Fu, B.S.
Headshot of Tsion Mekonnen
Postbaccalaureate Fellow
Tsion Mekonnen, B.S.
Headshot of Justin Mirazee
Predoctoral IRTA (Graduate Student)
Justin Mirazee, B.S.
Postbaccalaureate Fellow (IRTA)
Sri Nair, B.S.
Headshot of Nikos
Clinical Fellow
Nikos Svoronos, M.D., Ph.D.

News

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on our news section.