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CARnation Consortium

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CARnation Consortium logo

The Carnation Consortium is a multi-institution, multidisciplinary collaborative effort encompassing retrospective and prospective studies focused on improving outcomes following CAR T-cell therapy in children and young adults.

Research

CAR T-cell Multicenter Analysis (CAR-MA)

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CARMA logo

CAR-MA is a multicenter retrospective effort focused on 1) studying factors that impact CAR T-cell outcomes; 2) characterizing toxicities of CAR T-cells and 3) evaluating optimization strategies for children and young adults receiving CAR T-cells for leukemia.     

Publications: 

Conferences

10 Years of CAR T-cells in POB - July 2022

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A banner showing an immune cell celebrating the 10 year anniversary of CAR T cells in POB.

On July 13th, 2022, the POB celebrated the 10 year anniversary of the first patient infused with CD19 CAR T-cells in the Pediatric Oncology Branch. POB staff honored our patients and families and gave talks on key research advancements and milestones in immunotherapy research. Dr. Steve Rosenberg gave the keynote address, "The History of CD19 CAR." 

Watch a recording of the symposium here.

CAR T-cell Therapy: Beyond the Storm - May 2020

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Beyond the storm image

Held virtually in May 2020, this conference served to bring together leading institutions and investigators focused on pediatric CAR T-cell efforts for an information exchange to specifically focus on other elements of CAR T-cell toxicities, beyond cytokine release syndrome (CRS).  One aim was to highlight the biologic underpinnings of various elements of the extended toxicity profile exhibited in patients and compile current approaches and best practices utilized in toxicity mitigation and management strategies. Furthermore, with novel antigens and CAR T-cell targets, this conference helped to establish standardized metrics of monitoring for these comprehensive toxicities as we go beyond B-cell targeting. This conference served to lay the foundation of how to best study these extended outcomes and optimize care for patients receiving CAR T-cell therapy, beyond the storm.

Read the resulting publication: Shalabi H., et al. “Beyond the storm - subacute toxicities and late effects in children receiving CAR T cells.” Nat Rev Clin Onc. 2020.

 

CARnation Consortium Team Members

NCI Team

  • Bonnie Yates
  • Sara Silbert
  • Toni Foley

Children’s Hospital of Philadelphia

Seattle Children’s Hospital

Medical College of Wisconsin/CIBMTR

St. Jude

Children’s Hospital Los Angeles

Children’s Hospital Colorado

Dana Farber Cancer Institute

UT Southwestern