Headshot of Sara Silbert

Sara K. Silbert, M.D., M.H.Sc

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch


Dr. Silbert is a pediatric oncologist in the Hematologic Malignancies Section. As a dually boarded oncologist and palliative medicine physician, her clinical and research interests lie at the intersection of furthering novel immunotherapies for pediatric cancers and optimizing patient quality of life. Her clinical focus is on the treatment of children and young adults with relapsed/refractory hematologic malignancies using early phase chimeric antigen receptor (CAR) T cell therapies.  Additional interests include the measure and management of CAR toxicities and the integration of palliative care into early phase oncology trials.

Areas of Expertise

Pediatric Oncology
Leukemia And Lymphoma
Pediatric Palliative Care
Chimeric Antigen Receptor (CAR-T) Cell Therapy For Pediatric Leukemia

Information for Patients

Learn more about the Leukemia, Lymphoma, Transplant and Cell Therapy Team and clinical trials


Selected Recent Publications

How Should We Determine the Value of CAR T-Cell Therapy?

Sara Silbert, Gregory A Yanik, Andrew G Shuman
AMA J Ethics. 21/10: 2019.
Full-Text Article
[ Journal Article ]

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion

Leila Amini, Sara K Silbert, Shannon L Maude, Loretta J Nastoupil, Carlos A Ramos, Renier J Brentjens, Craig S Sauter, Nirali N Shah, Mohamed Abou-El-Enein
Nat Rev Clin Oncol. 19/5: 2022.
Full-Text Article
[ Journal Article ]

Tandem hematopoietic stem cell transplant considerations in families with multiple siblings affected by DOCK8 deficiency

Sara Silbert, Kristen Cole, Sima Z Bedoya, Alexandra F Freeman, Jennifer S Whangbo, Daniele N Avila, Helen C Su, Bonnie Yates, Monica Epstein, David S Wendler, Sung-Yun Pai, Dennis D Hickstein, Lori Wiener, Nirali N Shah
Bone Marrow Transplant. 57/11: 2022.
Full-Text Article
[ Journal Article ]

CD19/22 CAR T cells in children and young adults with B-ALL: phase 1 results and development of a novel bicistronic CAR

Haneen Shalabi, Haiying Qin, Angela Su, Bonnie Yates, Pamela L Wolters, Seth M Steinberg, John A Ligon, Sara Silbert, Kniya DéDé, Mehdi Benzaoui, Sophia Goldberg, Sooraj Achar, Dina Schneider, Shilpa A Shahani, Lauren Little, Toni Foley, John C Molina, Sandhya Panch, Crystal L Mackall, Daniel W Lee, Christopher D Chien, Marie Pouzolles, Mark Ahlman, Constance M Yuan, Hao-Wei Wang, Yanyu Wang, Jon Inglefield, Mary Anne Toledo-Tamula, Staci Martin, Steven L Highfill, Gregoire Altan-Bonnet, David Stroncek, Terry J Fry, Naomi Taylor, Nirali N Shah
Blood. 140/5: 2022.
Full-Text Article
[ Journal Article ]

Fertility and CAR T-cells: Current practice and future directions

John A Ligon, Abigail Fry, Jacqueline Y Maher, Toni Foley, Sara Silbert, Bonnie Yates, Veronica Gomez-Lobo, Lori Wiener, Nirali N Shah
Transplant Cell Ther. 28/9: 2022.
Full-Text Article
[ Journal Article ]