We conduct collaborative clinical trials that focus on developing targeted agents and applying immunotherapy to treat high risk childhood leukemias and lymphomas that do not respond to chemotherapy. Our patients come to us from all over the world to receive treatment when previous therapies have failed. To learn more about our clinical trials, please contact our team.
Leukemia, Lymphoma, Transplant and Cell Therapy Team
Our highly trained team is focused on developing and conducting a wide range of clinical trials in a quest to improve outcomes for children, adolescents, and young adults with leukemias and lymphomas.
Although cure rates are excellent for many subtypes of childhood leukemia and lymphoma, new approaches are needed to overcome resistance to standard therapies and to decrease treatment-associated sequelae in survivors of pediatric cancer.
Our goal, as the Leukemia, Lymphoma, Transplant and Cellular Therapy Team of the Hematologic Malignancies Section, is to develop cutting-edge, early-phase clinical trials for patients with high-risk hematologic malignancies, with a specific focus on developing novel therapies which can overcome chemotherapeutic or immunotherapeutic resistance. The trials implemented by our section seek to improve upon existing strategies, or address unmet needs, and incorporate the study of leukemia biology to optimize outcomes.
Our group is specifically focused on advancing CAR T-cell therapy for children and young adults with acute leukemias and lymphomas. Our focus is on using CAR T-cells to target new tumor markers in acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) and learn how to best deliver this care safely and effectively.
Our team is a member of the CARnation Consortium, a group of expert researchers and clinicians treating pediatric hematologic malignancies with immunotherapy.
Patients & Providers
Contact Our Team
240-858-3536 (Lauren Little, RN) or 240-383-6185 (Toni Foley, RN)
Current research activities:
- Development of anti-CD19, anti-CD22 and anti-CD33 chimeric antigen receptor (CAR) therapy and other targeted agents and immune-based therapies
- Novel approaches to hematopoietic stem cell transplantation, with a focus on immune restoration and treatment of patients with primary immune deficiencies
- Post-transplant allogeneic immunotherapy to direct anti-tumor responses and treatment of relapse after transplant
- Bedside-to-bench based studies designed to support current and future clinical trials
Collaborative research efforts include studies on:
- CAR-T cell toxicity
- Infectious disease
- Patient reported outcomes
- Late effects
- Antigen modulation
- Stem cell transplant
- Education of minors who donate stem cell
Recent Press and Publications:
- Listen: NPR Health News Article - Scientists Race to Improve 'Living Drugs' to Fight Cancer
- Watch: The Role of Immunotherapy in Childhood Cancer Treatment
- Watch: Moving Therapies from the Relapse/Refractory Setting to the Frontline
- Watch: 2018 NIH Demystifying Medicine Lecture: Is Childhood Leukemia Curable?
- Virtual Meeting: CAR-T Cell Therapy: Beyond The Storm
- Read: Bispecific CD19/CD22 CAR T Cells Active in Pediatric Relapsed ALL
- Read: NCI Initiative Aims to Boost CAR T-cell Therapy in Clinical Trials
- Read: Near the Nation's Capitol Lies a 'House of Hope'
Call one of our nurses:
Lauren Little, RN 240-858-3536
Toni Foley, RN 240-383-6185
Or reach us by email:
We will get in contact with you and your medical team to collect all of the necessary medical records and discuss the next steps of meeting with our team at the NIH Clinical Center.