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Rosa Nguyen

Rosa Nguyen, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch

RESEARCH SUMMARY

Dr. Nguyen is a pediatric oncologist and physician-scientist specializing in the discovery and preclinical development of immunotherapies for the treatment of children with neuroblastoma. She earned her M.D. from the University of Hamburg, Germany, and completed her pediatric residency at the University of Maryland and her pediatric hematology-oncology fellowship training at St. Jude Children’s Research Hospital. Subsequently, she obtained her Ph.D. under the mentorship of Dr. Michael A. Dyer, studying natural killer cells and their therapeutic role in pediatric cancer.

Areas of Expertise

1) monoclonal antibody therapy 2) cytokine biology 3) natural killer (NK) cell biology 4) adoptive CAR T therapy 5) mouse modeling

Information for Patients

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Publications

Selected Recent Publications

Immunotherapy approaches targeting neuroblastoma

Nguyen R, Thiele CJ.
Current Journal Pediatr.. Feb 1;33(1): 19-25, 2021. [ Journal Article ]

Next-generation humanized patient-derived xenograft mouse model for pre-clinical antibody studies in neuroblastoma

Nguyen R, Patel AG, Griffiths LM, Dapper J, Stewart EA, Houston J, Johnson M, Akers WJ, Furman WL, Dyer MA.
Cancer Immunol Immunother.. Mar;70(3): 721-732, 2021. [ Journal Article ]

Longitudinal NK cell kinetics and cytotoxicity in children with neuroblastoma enrolled in a clinical phase II trial

Nguyen R, Sahr N, Sykes A, McCarville MB, Federico SM, Sooter A, Cullins D, Rooney B, Janssen WE, Talleur AC, Triplett BM, Anthony G, Dyer MA, Pappo AS, Leung WH, Furman WL.
J Immunother Cancer.. Mar;8(1):: e000176, 2020. [ Journal Article ]

Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma

Nguyen R, Moustaki A, Norrie JL, Brown S, Akers WJ, Shirinifard A, Dyer MA.
Clin Cancer Res. . Dec 15;25(24): 7554-7564, 2019. [ Journal Article ]

A phase II clinical trial of adoptive transfer of haploidentical natural killer cells for consolidation therapy of pediatric acute myeloid leukemia

Nguyen R, Wu H, Pounds S, Inaba H, Ribeiro RC, Cullins D, Rooney B, Bell T, Lacayo NJ, Heym K, Degar B, Schiff D, Janssen WE, Triplett B, Pui CH, Leung W, Rubnitz JE.
J Immunother Cancer. Mar 20;7(1): 81, 2019. [ Journal Article ]

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