Dr. Rosa Nguyen

Rosa Nguyen, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch


Dr. Nguyen is a pediatric oncologist and physician-scientist specializing in the discovery and preclinical development of immunotherapies for children with solid tumors, such as neuroblastoma. The goal of her research is to translate new and effective immunotherapies from the bench to the bedside and understand the immunologic mechanisms that underlie tumor response and immune evasion.

Areas of Expertise

Information for Patients

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Selected Recent Publications

Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

Ming Sun, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Haiying Qin, Nan Li, Charlie Seibert, Michael C Kelly, Eytan Ruppin, Mitchell Ho, Carol J Thiele, Rosa Nguyen
J Immunother Cancer. 11/1: 2023.
Full-Text Article
[ Journal Article ]

Anti-GD2 Antibodies Conjugated to IL15 and IL21 Mediate Potent Antitumor Cytotoxicity against Neuroblastoma

Rosa Nguyen, Xiyuan Zhang, Ming Sun, Shahroze Abbas, Charlie Seibert, Michael C Kelly, Jack F Shern, Carol J Thiele
Clin Cancer Res. 28/17: 3785-3796, 2022.
Full-Text Article
[ Journal Article ]

Longitudinal NK cell kinetics and cytotoxicity in children with neuroblastoma enrolled in a clinical phase II trial

Nguyen R, Sahr N, Sykes A, McCarville MB, Federico SM, Sooter A, Cullins D, Rooney B, Janssen WE, Talleur AC, Triplett BM, Anthony G, Dyer MA, Pappo AS, Leung WH, Furman WL.
J Immunother Cancer.. Mar;8(1):: e000176, 2020. [ Journal Article ]

Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of Neuroblastoma

Nguyen R, Moustaki A, Norrie JL, Brown S, Akers WJ, Shirinifard A, Dyer MA.
Clin Cancer Res. . Dec 15;25(24): 7554-7564, 2019. [ Journal Article ]

Cooperative armoring of CAR and TCR T-cells by T cell-restricted IL-15 and IL-21 universally enhances solid tumor efficacy.

Nguyen R, Doubrovina E, Mousset CM, Jin BY, Okada R, Zhang X, Clavel A, Reyes-González JM, Dyomin V, Diaz L, Zhang L, Abbas S, Sun M, Hsieh CM, Ho M, Shern JF, Gulley JL, Hinrichs CS.
Clin Cancer Res. 2023.
Full-Text Article
[ Journal Article ]

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