Dr. Heske headshot

Christine M. Heske, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Heske is a physician-scientist with a laboratory and clinical research focus on novel therapeutic agents for pediatric sarcomas including rhabdomyosarcoma and Ewing sarcoma. Specifically, she seeks to identify and evaluate new therapeutic targets for these cancers by understanding the mechanisms behind therapeutic resistance and developing strategies to overcome such resistance through targeting tumor metabolism and DNA damage repair.

Areas of Expertise

DNA Damage and Repair
Early Phase Clinical Trials

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Recent Publications

Inhibition of NAD+-dependent metabolic processes induces cellular necrosis and tumor regression in rhabdomyosarcoma models.

Grace B McKay-Corkum, Victor J Collins, Choh Yeung, Takeshi Ito, Sameer H Issaq, David Holland, Ksenia Vulikh, Yiping Zhang, Unsun Lee, Haiyan Lei, Arnulfo Mendoza, Jack F Shern, Marielle E Yohe, Kazutoshi Yamamoto, Kelli Wilson, Jiuping Ji, Baktiar O Karim, Craig J Thomas, Murali C Krishna, Leonard M Neckers, Christine M Heske
Clin Cancer Res. 2023.
Full-Text Article
[ Journal Article ]

Phase I trial of ganitumab plus dasatinib to cotarget the insulin-like growth factor 1 receptor and Src family kinase YES in rhabdomyosarcoma

Akshintala S, Sundby RT, Bernstein D, Glod JW, Kaplan RN, Yohe ME, Gross AM, Derdak J, Lei H, Pan A, Dombi E, Palacio-Yance I, Herrera KR, Miettinen MM, Chen HX, Steinberg SM, Helman LJ, Mascarenhas L, Widemann BC, Navid F, Shern JF, Heske CM.
Clin Cancer Res. 2023.
Full-Text Article
[ Journal Article ]

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J 3rd, Dowdy T, Ruiz-Rodado V, Lita A, Mendoza A, Shern JF, Larion M, Helman LJ, Stott GM, Krishna MC, Hall MD, Darley-Usmar V, Neckers LM, Heske CM.
Cancer Res. 2019.
Full-Text Article
[ Journal Article ]

Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma

Heske CM, Davis MI, Baumgart JT, Wilson K, Gormally MV, Chen L, Zhang X, Ceribelli M, Duveau DY, Guha R, Ferrer M, Arnaldez FI, Ji J, Tran HL, Zhang Y, Mendoza A, Helman LJ, Thomas CJ.
Clin Cancer Res. 2017.
Full-Text Article
[ Journal Article ]

Job Vacancies

Interested in joining the Heske Lab?

Postdoctoral fellows (Ph.D., M.D.), postbaccalaureate fellows, and summer interns (undergraduate) have been trained in the Heske lab since it opened in 2016. Interested candidates should send a CV and statement of interest to

Watch the video: Launch Your Postdoc Career with a Tenure-Track Investigator


Learn more about CCR research advances, new discoveries and more
on our news section.