Jennifer N. Brudno, M.D.

Jennifer N. Brudno, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Surgery Branch


Dr. Brudno researches the use of chimeric antigen receptor (CAR) T-cell therapy to treat cancers of the blood, including Non-Hodgkin lymphoma, Hodgkin lymphoma, acute lymphoblastic leukemia (ALL), and multiple myeloma. Her focus is in the development of phase I clinical trials. She is also interested in patient safety, particularly in optimizing patient safety for cellular immunotherapies.

Areas of Expertise

Hodgkin And Non-Hodgkin Lymphoma
Multiple Myeloma
Chimeric Antigen Receptor (CAR) T-cell Therapy
Toxicities Of Immunotherapy

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.


Selected Key Publications

T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma

Brudno JN, Maric I, Hartman SD, Rose JJ, Wang M, Lam N, Stetler-Stevenson M, Salem D, Yuan C, Pavletic S, Kanakry JA, Ali SA, Mikkilineni L, Feldman SA, Stroncek DF, Hansen BG, Lawrence J, Patel R, Hakim F, Gress RE, Kochenderfer JN.
J Clin Oncol. 36(22): 2267-2280, 2018. [ Journal Article ]

Chimeric antigen receptor T-cell therapies for lymphoma

Brudno JN, Kochenderfer JN.
Nat Rev Clin Oncol. 15(1): 31-36, 2018. [ Journal Article ]

Toxicities of chimeric antigen receptor T cells: recognition and management

Brudno JN, Kochenderfer JN.
Blood. 127(26): 3321-3330, 2016. [ Journal Article ]

Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease

Brudno JN, Somerville RP, Shi V, Rose JJ, Halverson DC, Fowler DH, Gea-Banacloche JC, Pavletic SZ, Hickstein DD, Lu TL, Feldman SA, Iwamoto AT, Kurlander R, Maric I, Goy A, Hansen BG, Wilder JS, Blacklock-Schuver B, Hakim FT, Rosenberg SA, Gress RE, Kochenderfer JN.
J Clin Oncol. 34(10): 1112-1121, 2016. [ Journal Article ]

Discordant bone marrow involvement in non-Hodgkin lymphoma

Brudno J, Tadmor T, Pittaluga S, Nicolae A, Polliack A, Dunleavy K.
Blood. 127(8): 965-970, 2016. [ Journal Article ]