Elaine S. Jaffe, M.D.

Elaine S. Jaffe, M.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10, Room 3S235
  • Bethesda, MD 20892-1500
  • 301-480-8040 (office)
  • 301-480-8461 (direct)
  • 301-480-8089
Laboratory of Pathology


Dr. Jaffe has conducted pioneering studies related to the classification of malignant lymphomas and has led an international effort for consensus among clinicians and pathologists. Her work focuses on lymphomas as tumors of the immune system. Using a combination of immunophenotypic, genomic and genetic approaches, her group is examining the pathogenesis of lymphomas, mechanisms of transformation, and signaling pathways involved in control of cellular proliferation and differentiation. These studies delineate new disease entities and provide a basis for therapy. Her work has established a new paradigm for the classification of lymphoid neoplasms.

Areas of Expertise

Immunophenotypic Studies
Non-Hodgkin Lymphoma 
Hodgkin Lymphoma
Epstein Barr Virus


Selected Key Publications

Best Practices Guideline for the Pathologic Diagnosis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma

Jaffe ES, Ashar BS, Clemens MW, Feldman AL, Gaulard P, Miranda RN, Sohani AR, Stenzel T, Yoon SW.
J Clin Oncol. 38(10): 1102-11, 2020. [ Journal Article ]

Recurrent somatic JAK3 mutations in NK-cell enteropathy

Xiao W, Gupta GK, Yao J, Jang YJ, Xi L, Baik J, Sigler A, Kumar A, Moskowitz AJ, Arcila ME, Raffeld M, Pittaluga S, Dogan A, Jaffe ES.
Blood. 134(12): 986-91, 2019. [ Journal Article ]

Gene Expression Profiling of Mediastinal Gray Zone Lymphoma and Its Relationship to Primary Mediastinal B-cell Lymphoma and Classical Hodgkin Lymphoma

Pittaluga S, Nicolae A, Wright G, Melani C, Roschewski M, Steinberg S, Huang D, Staudt LM, Jaffe ES, Wilson WH
Blood Cancer Discov. 1 (2): 155-161, 2020.
Full-Text Article
[ Journal Article ]

The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy

Egan C, Lack J, Skarshaug S, Pham TA, Abdullaev Z, Xi L, Pack S, Pittaluga S, Jaffe E S, Raffeld M
Mod Pathol. 34 (2) : 336-347, 2021. [ Journal Article ]

Job Vacancies

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Medical Technologist
Theresa M. Davies-Hill
Clinical Fellow
Jeremiah Karrs, D.O.
Clinical Fellow
Annapurna Saksena, M.D.
Postbaccalaureate Fellow (CRTA)
Grace Smith
Patient Care Coordinator (Contr.)
Anjana Venkatesan
Clinical Fellow
Saber Tadros , MD, PhD
Clinical Fellow
Neval Ozkaya , MD


Cover of Blood, Vol. 127, No. 20, 2016

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Published Date

A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.


The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, and Jaffe ES. Blood 2016 May 19;127(20): 2375-90.

Cover of Hematopathology, Second Edition, 2017

Hematopathology, 2nd Edition

Published Date

The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource for both residents and practicing pathologists alike.


Arber, Daniel A., Elias Campo, Nancy L. Harris, Elaine Sarkin Jaffe, and Leticia Quintanilla-Martinez. Hematopathology. Philadelphia, PA: Elsevier, 2017. Print.


Blood 2016 May 19;127(20): 2375-90.