Steven A. Rosenberg, M.D., Ph.D.

Steven A. Rosenberg, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10 - Hatfield CRC, Room 3-3940
  • Bethesda, MD 20892-1201
  • 240-858-3080


Dr. Rosenberg has pioneered the development of effective immunotherapies for patients with advanced cancer. His studies of cell transfer immunotherapy using tumor infiltrating lymphocytes (TIL) have resulted in durable complete remissions in patients with advanced solid cancers. He has also pioneered the development of gene therapy and was the first to successfully insert foreign genes into humans. His recent studies of the adoptive transfer of genetically modified lymphocytes using chimeric antigen receptors (CAR) or conventional T-cell receptors (TCR) have resulted in the regression of metastatic cancer in patients with lymphomas and solid cancers. His current research is aimed at defining the host immune response of patients to their cancers. These studies emphasize the ability of human lymphocytes to recognize unique cancer antigens and the identification of anti-tumor T-cell receptors that can be exploited to develop new cell transfer immunotherapies. As Chief, Dr. Rosenberg also oversees the Branch’s extensive clinical program aimed at translating scientific advances into effective immunotherapies for patients with advanced cancers arising from the breast, gastrointestinal tract, and pancreas.

Areas of Expertise

Tumor-Infiltrating Lymphocytes
T Cell Receptors
Gene Therapy

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Learn more about the Surgery Branch / Cancer Immunotherapy Research Fellowship or submit an application.     


Selected Key Publications

Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers

Lowery FJ, Krishna S, Yossef R, Parikh NB, Chatani PD, Zacharakis N, Parkhurst MR, Levin N, Sindiri S, Sachs A, Hitscherich KJ, Yu Z, Vale NR, Lu Y, Zheng Z, Jia L, Gartner JJ, Hill VK, Copeland AB, Nah SK, Masi RV, Gasmi B, Kivitz S, Paria BC, Florentin M, Kim SP, Hanada K, Li YF, Ngo LT, Ray S, Shindorf ML, Levi ST, Shepherd R, Toy C, Parikh AY, Prickett TD, Kelly MC, Beyer R, Goff SL, Yang JC, Robbins PF, Rosenberg SA
Science. 2022.
Full-Text Article
[ Journal Article ]

'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations

Tran E, Robbins PF, Rosenberg SA
Nat Immunol. 18(3): 255-262, 2017. [ Journal Article ]

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

Krishna S, Lowery FJ, Copeland AR, Bahadiroglu E, Mukherjee R, Jia L, Anibal JT, Sachs A, Adebola SO, Gurusamy D, Yu Z, Hill V, Gartner JJ, Li YF, Parkhurst M, Paria B, Kvistborg P, Kelly MC, Goff SL, Altan-Bonnet G, Robbins PF, Rosenberg SA.
Science. 370(6522): 1328-1334, 2020. [ Journal Article ]

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

Zacharakis N, Chinnasamy H, Black M, Xu H, Lu YC, Zheng Z, Pasetto A, Langhan M, Shelton T, Prickett T, Gartner J, Jia L, Trebska-McGowan K, Somerville RP, Robbins PF, Rosenberg SA, Goff SL, Feldman SA.
Nat Med. 24(6): 24-730, 2018. [ Journal Article ]

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

Tran E, Robbins PF, Lu YC, Prickett TD, Gartner JJ, Jia L, Pasetto A, Zheng Z, Ray S, Groh EM, Kriley IR, Rosenberg SA
N Engl J Med. 375(23): 2255-2262, 2016. [ Journal Article ]

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postdoctoral fellow (visiting)
Lior Levy, Ph.D.
Research Fellow (Visiting)
Nivi Ratnam, Ph.D.
Postdoctoral Fellow (Visiting)
Noam Levin, Ph.D.
Postdoctoral Fellow
Melinda Magna, M.S., Ph.D.
Research Nurse Specialist
Lori S. McIntyre, R.N., B.S.N.
Research Nurse
Mica Dawson, B.S.N., R.N.
Research Nurse
Katarzyna (Kate) Borkowski, MPH, B.S.N, R.N.
Senior Research Nurse Specialist
Madeline (Maddie) Rilko, MSN
Research Nurse Specialist
Rukayat (Ru) Salau, M.S., R.N.
Research Nurse Specialist
Debra (Debbie) Warga, B.S., B.S.N.
Patient Care Coordinator
Medjine Jeanty, A.A.
Patient Care Coordinator (Contr.)
Deepti Jillella Marshall
Research Nurse Specialist
Sarah C. Ramirez, R.N., B.S.N.
Research Nurse
Xuemei (Sherry) Chen, R.N.
Research Nurse
Beisha (Belle) Zhu, R.N.
Information Technology Specialist
Donald E. White
Information Technology Specialist
Tho Nguyen, B.S.
Quality Assurance Manager (Contr.)
John Fisher
Satyajit Ray, Ph.D.