CCR News and Events
Potent new LDHI inhibitor disrupts tumor growth in mice
Researchers have identified a potent LDH inhibitor, which can disrupt the energy production of tumors in mice. After exposure to the LDH inhibitor, the cancers cells began to rely on a different form of energy production, which could also be disrupted by using a second drug. Combining the two drugs had a potent anti-cancer effect. Read more...
New video: Discovering new far-red fluorescent probes
Nov 18, 2019
Fluorescent probes are workhorse molecules used by biologists to illuminate the inner workings of cancer cells. By lighting up cell components of interest, researchers can then observe cells in action through high-powered microscopes. This new video explains a novel class of far-red fluorescent probes synthesized by Martin Schnermann, Ph.D., Senior Investigator in CCR’s Chemical Biology Laboratory, and his team. Read more...
Clinical trial tests combination therapy for relapsed hairy cell leukemia
Nov 15, 2019
Hairy cell leukemia (HCL) is a rare and slow-growing leukemia in which bone marrow overproduces abnormal B lymphocytes, a type of white blood cell. Under a microscope, these malignant cells appear to be covered with tiny hair-like projections. In this study, patients will receive an immunotoxin called moxetumomab pasudotox to study its effect on relapsed HCL. Read more...
Pancreatic Cancer Research
Nov 4, 2019
November is Pancreatic Cancer Awareness Month. We have many researchers, both in the basic and clinical disciplines, who are working on pancreatic cancer. Learn more...
Lung Cancer Research
Nov 4, 2019
November is Lung Cancer Awareness Month. Our research portfolio includes investigators making important discoveries in lung cancer research. Read more...
Elaine Jaffe named an NIH Distinguished Investigator
Oct 29, 2019
Elaine Jaffe, M.D., Senior Investigator in the Laboratory of Pathology, has been selected as an NIH Distinguished Investigator, a prestigious title reserved for tenured intramural senior investigators who are at the highest level in their fields. Dr. Jaffe has conducted pioneering studies related to the classification of malignant lymphomas and has led an international effort for consensus among clinicians and pathologists. Read more...
Clinical trial will test new treatment to improve survival rates for patients with operable gastrointestinal tumors
Oct 28, 2019
A clinical phase II trial at the NIH Clinical Center will test the effectiveness of a monoclonal antibody used immediately before and after surgery for patients with primary pancreatic and bile duct cancer and those who have liver metastasis from colorectal cancer. The trial is investigating whether this treatment can prevent the disease from coming back after surgery. Read more...
Clinical trial studies antibiotic therapy for fibrolamellar hepatocellular carcinoma, a rare liver cancer
Oct 25, 2019
Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer that usually grows in teens and young adults. Unresectable FLC usually does not improve with surgery, chemotherapy or radiation therapy. Tim F. Greten, M.D., Deputy Chief of the Thoracic and GI Malignancies Branch, is leading a study that tests the theory that certain bacteria in the gut may influence the development of FLC. Read more...
James Kochenderfer receives 2019 FNIH Trailblazer Prize for Clinician-Scientists
Oct 24, 2019
James Kochenderfer, M.D., Investigator in the Surgery Branch, has received the 2019 Foundation for the National Institutes of Health (FNIH) Trailblazer Prize for Clinician-Scientists. The award recognizes the outstanding contributions of early career clinician-scientists whose work has the potential to or has led to innovations in patient care. Dr. Kochenderfer was selected as the 2019 recipient for developing immunotherapies that leverage chimeric antigen receptor (CAR) T cells to treat blood cancers, including lymphoma and multiple myeloma. Read more...
Metastatic breast cancer survivor shares her clinical trial story
Oct 23, 2019
We’re celebrating breast cancer awareness month by sharing the story of Samantha Seinfeld, a metastatic breast cancer survivor who participated in a CCR first-in-human clinical trial over 10 years ago. Since then, she has remained cancer-free. Margaret Gatti-Mays, M.D., M.P.H., F.A.C.P., Assistant Research Physician in the Laboratory of Tumor Immunology and Biology, and James Gulley, M.D., Ph.D., Chief of the Genitourinary Malignancies Branch, are currently evaluating Samantha’s unusual immune response in hopes of improving the responses of other patients. Read more...
Stanley Lipkowitz and Alexandra Zimmer answer breast cancer “Redditor” questions
Oct 22, 2019
Stanley Lipkowitz, M.D., Ph.D., Chief of the Women’s Malignancies Branch (WMB), and Alexandra Zimmer, M.D., Assistant Research Physician in WMB, recently answered questions about breast cancer during a Reddit “Ask Me Anything” (AMA). During the event, Drs. Lipkowitz and Zimmer discussed topics ranging from recent advances in breast cancer treatment to genetic and environmental factors that influence risk for disease. Read more...