Clinical trial tests combination therapy for relapsed hairy cell leukemia
Hairy cell leukemia (HCL) is a rare and slow-growing leukemia in which bone marrow overproduces abnormal B lymphocytes, a type of white blood cell. Under a microscope, these malignant cells appear to be covered with tiny hair-like projections. In this study, patients will receive an immunotoxin called moxetumomab pasudotox to study its effect on relapsed HCL. Read more...
In patients with severe chronic lymphocytic leukemia, B cells get stuck in hyperactive mode
Aug 5, 2019
Analyzing how cancer cells respond to stress signals could help clinicians assess the severity of disease in patients with chronic lymphocytic leukemia, according to new research from the Center for Cancer Research, Memorial Sloan Kettering Cancer Center and the National Heart, Lung and Blood Institute. Read more...
Amy LeBlanc featured in Wired
Jul 22, 2019
Amy LeBlanc, D.V.M., Director of the Center for Cancer Research’s Comparative Oncology Program, was recently featured in a Wired article that discusses the role of dogs in human cancer research. In the article, Dr. LeBlanc says that the comparative oncology Cancer Moonshot projects “… are developing very critical, biologically rich information in patients who happen to be dogs.” Read more...
Landmark discovery: H2AX as a sensor of DNA damage
Jul 16, 2019
William Bonner’s curiosity about histones led to the discovery that the protein H2AX is altered in response to harmful DNA damage called a double-strand break. This powerful tool has led to breakthroughs in both basic and clinical cancer research. Read more...
New mechanism for regulating differentiation discovered in human embryonic stem cells
Jul 15, 2019
Researchers in the Center for Cancer Research have discovered a new mechanism involving a nuclease complex called the RNA exosome that represses differentiation of human embryonic stem cells. This represents the first time this mechanism has been studied in these cells. Read more...
Ying Zhang’s research featured in new NIH Intramural Research Program blog
Jul 15, 2019
Ying Zhang, Ph.D., Senior Investigator in the Laboratory of Cellular and Molecular Biology, is featured in a new NIH Intramural Research Program blog post. The blog post, “Scientific Detour Advances Understanding of Fatty Liver Disease," focuses on Dr. Zhang’s research, including a recent study that could eventually lead to preventing or reversing unhealthy amounts of fat storage in the liver. Read more...
Doug Lowy receives Distinguished Scientist Award from the Association of American Cancer Institutes
Jul 15, 2019
Doug Lowy, M.D., Acting Director of NCI and Chief of the Laboratory of Cellular Oncology, has been selected to receive the Association of American Cancer Institutes (AACI) Distinguished Scientist Award. AACI is recognizing Dr. Lowy for his long-term research on the molecular biology of tumor viruses and growth regulation, his role in enabling the development of human papillomavirus (HPV) vaccines and his exploration of oncogenes and tumor suppressor genes and their signaling pathways. Read more...
Gene-regulating microRNAs gain control over hundreds of new genes with common sequence modification
Jul 11, 2019
MicroRNAs have an enormous influence over what happens inside cells. By blocking the activity of specific sets of genes, they help control virtually every known biological pathway and process. Disruptions in microRNAs have been linked to many diseases, and understanding how these molecules function, which genes they control and how they themselves are regulated are high priorities in cancer research. Read more...
CCR scientists receive the Presidential Early Career Award for Scientists and Engineers
Jul 11, 2019
John Brognard, Ph.D., Investigator in the Laboratory of Cell and Developmental Signaling, Romina Goldszmid, Ph.D., Investigator in the Cancer and Inflammation Program, and Anish Thomas, M.D., Investigator in the Developmental Therapeutics Branch, are recipients of the Presidential Early Career Award for Scientists and Engineers (PECASE). The PECASE is the highest honor bestowed by the United States Government to outstanding scientists and engineers who are beginning their independent research careers and who show exceptional promise for leadership in science and technology. Established in 1996, the PECASE acknowledges the contributions scientists and engineers have made to the advancement of science, technology, engineering and mathematics education and to community service as demonstrated by scientific leadership, public education and community outreach. Read more...
Clinical Trial Conversation: Jonathan Hernandez describes metastatic colorectal cancer clinical trial
Jul 8, 2019
Colorectal cancer (CRC) starts in the colon and/or rectum and often metastasizes, or spreads, to many sites in the body. In a certain set of patients, however, CRC metastasizes only to the liver. Jonathan Hernandez, M.D., of the Surgical Oncology Program, is leading a new clinical trial to study how well CRC patients with liver-only metastases respond to treatment with a hepatic artery infusion pump. Dr. Hernandez describes the trial in this new video. Read more...
Jonathan Hernandez discusses surgical oncology with Behind the Knife podcast
Jul 2, 2019
Jonathan Hernandez, M.D., Investigator in the Surgical Oncology Program, was recently featured in a Behind the Knife podcast. During the episode, Dr. Hernandez discussed the surgical oncology match process and his research on ex vivo tissue preservation to study tumors. The full podcast is available online. Read more...