Advanced imaging technology reveals pulsed hormone release regulates gene transcription
Using advanced microscopic imaging technology, CCR investigators have correlated a pulsed pattern of hormone release with bursts of transcription, the process in which the genetic information encoded by DNA is written into RNA. They are the first researchers to observe this process at a gene-specific level. Read more...
Udo Rudloff discusses germline mutations with Bloomberg podcast
Jun 6, 2019
Udo Rudloff, M.D., Ph.D., Investigator in the Pediatric Oncology Branch, was recently featured on Bloomberg’s Prognosis podcast.During the episode, “Should We Be Scared of Our DNA?," Dr. Rudloff discussed CDH1 germline mutations and risk of hereditary diffuse gastric cancer (HDGC) in an evolving environment, which he is currently studying as part of the Rare Tumor Initiative. The full podcast is available online. Read more...
Clinical trial tests new methods for blood stem cell transplant in lymphoma
Jun 6, 2019
Peripheral T-cell lymphoma (PTCL) is a rare, often fast-growing cancer of white blood cells. A new clinical trial is investigating to see how a new approach to blood stem cell transplant can impact patients with PTCL. Read more...
June is Cancer Immunotherapy Awareness Month
Jun 5, 2019
To celebrate Cancer Immunotherapy Month this June, we are highlighting our researchers who have helped pioneer this research and continue to make seminal advances in this growing field. Read more...
Investigators test combination therapy for head and neck squamous cell carcinoma in new trial
Jun 4, 2019
Patients with recurrent head and neck squamous cell carcinoma (HNSCC) may be eligible to participate in a new clinical trial at the NIH Clinical Center. This trial tests a therapy of a novel radiosensitizer, birinapant, in combination with radiotherapy for patients whose HNSCC has come back at or near the place of the original tumor. Read more...
Registration now open for Frontiers in Light Microscopy
Jun 3, 2019
The Frontiers in Light Microscopy conference is a platform to discuss the latest advances in microscopy and biological imaging. The current state of the art in light microscopy will be presented by leading researchers in the field who will cover topics such as intravital imaging, super-resolution microscopy and light sheet microscopy. Sessions will include organelle dynamics and function, multicellular organisms and imaging the immune system. Read more...
Clinical trial tests a new drug therapy for recurrent ependymomas of the brain and spinal cord
May 28, 2019
Ependymomas are rare tumors that arise in the ependyma, the thin membrane that lines fluid-filled cavities in the brain and spinal cord, and there are limited treatment options for those that have already been treated with standard therapies. A new clinical trial is testing a drug that targets ependymomas that have a specific genetic signature. Read more...
Nataliya Buxbaum wins Magnetic Moments video competition
May 22, 2019
Nataliya P. Buxbaum, M.D., Assistant Clinical Investigator in the Experimental Transplantation and Immunology Branch, was named the overall winner of the International Society for Magnetic Resonance in Medicine’s Magnetic Moments Competition. The competition is designed for investigators to use video to describe their MRI-related research for a general audience. Dr. Buxbaum’s video describes her research using tracers to better and more safely image tumors. Read more...
Clinical study follows men with specific genetic changes to determine their risk for developing prostate cancer
May 16, 2019
Prostate cancer (PC) is the most common malignancy in American men. There is increasing evidence that there may be a link between PC and men who have a family history of ovarian or breast cancer. As researchers have learned more about the role of genetics in PC, they have taken a new approach to screening for the disease—targeting men whose genetic profiles put them at risk for developing PC. Read more...
Clinical trial to determine whether antibiotics can boost immune response in treating liver cancer
May 14, 2019
A new clinical trial at the NCI’s Center for Cancer Research is set to explore if eliminating certain bacteria in the gut will boost the immune system response in patients who have hepatocellular carcinoma and liver metastases.
Julius Strauss discusses promising immunotherapy drug for patients with HPV-related cancers
May 13, 2019
Julius Strauss, M.D., Assistant Research Physician in the Laboratory of Tumor Immunology and Biology, discussed a promising immunotherapy drug for patients with HPV-related cancers in a recent NCI Cancer Currents blog post. According to results from a phase 1 clinical trial, 33 percent of the 36 patients on the trial with HPV-positive tumors responded to the drug, and four of the responses lasted longer than 18 months. “This drug is a promising agent for patients with HPV-related cancers and may potentially benefit these patients more than traditional checkpoint therapies,” said Dr. Strauss. Read more...