News and Events
Drug shrinks nerve tumors in adults with neurofibromatosis type 1 in a clinical trial
Until recently, no effective treatments existed for non-cancerous inoperable nerve tumors, called plexiform neurofibroma, in adults. A clinical trial of the drug selumetinib shows it can cause tumor shrinkage and relieve symptoms, such as pain.
Read MoreClinical trial researching drug therapy for adults with colorectal or gastroesophageal cancer
A clinical trial led by Nicholas D. Klemen, M.D., Physician-Scientist Early Investigator in the Surgery Branch, is researching drug therapy for adults with colorectal or gastroesophageal cancer.
Read MoreClinical trial researching drug therapy for adults with HIV-related diseases
A clinical trial led by Ramya Ramaswami, M.B.B.S., M.P.H., Lasker Clinical Research Scholar in the HIV and AIDS Malignancy Branch, is researching drug therapy for two HIV-related diseases.
Read MoreClinical trial researching CAR T-cell therapy for leukemia and lymphoma
A clinical trial led by Jennifer N. Brudno, M.D., Associate Research Physician in the Surgery Branch, is researching CAR T-cell therapy for chronic lymphocytic leukemia and small lymphocytic lymphoma.
Read MoreClinical trial researching combination drug therapy for genitourinary tumors
A clinical trial led by Andrea B. Apolo, M.D., Senior Investigator in the Genitourinary Malignancies Branch, is researching combination drug therapy for rare genitourinary tract tumors.
Read MoreChuan Wu appointed to Senior Investigator at CCR
The CCR community congratulates Chuan Wu, M.D., Ph.D., who has been appointed Senior Investigator in the Experimental Immunology Branch. Wu studies the role of intestinal neuroimmune interactions in health and disease. His lab works to understand the cellular and molecular mechanisms of the dynamic interplay between the enteric nervous system and the immune system to build a comprehensive view of intestinal homeostasis and to discover new therapeutics for intestinal inflammatory diseases.
Read MoreImmunotherapy after surgery helps people with high-risk bladder cancer live cancer-free longer
Results from a large CCR clinical trial show that treatment with an immunotherapy drug may nearly double the length of time people with high-risk, muscle-invasive bladder cancer are cancer-free following surgical removal of the bladder. Researchers led by Andrea B. Apolo, M.D., Senior Investigator in the Genitourinary Malignancies Branch, found that postsurgical treatment with pembrolizumab (Keytruda), which is approved by the Food and Drug Administration (FDA) for treating at least 18 different cancers, was superior compared with observation.
Read MoreNIH study links neighborhood environment to prostate cancer risk in men with West African genetic ancestry
CCR researchers led by Stefan Ambs, Ph.D., M.P.H., Senior Investigator in the Laboratory of Human Carcinogenesis, found that West African genetic ancestry was associated with increased prostate cancer among men living in disadvantaged neighborhoods but not among men living in more affluent neighborhoods. The findings suggest that neighborhood environment may play a role in determining how genetic ancestry influences prostate cancer risk.
Read MoreOpting for a Novel Combination Treatment for Resistant Aggressive B-Cell Lymphoma
In 2020, Justin enrolled in a CCR trial testing a five-drug combination treatment called ViPOR for non-Hodgkin lymphoma. Four years later, his doctor Christopher J. Melani, M.D., Assistant Research Physician in the Lymphoid Malignancies Branch, describes Justin as likely cancer-free.
Read MoreDaniel Larson appointed Chief of the Laboratory of Receptor Biology and Gene Expression
The CCR community congratulates Daniel R. Larson, Ph.D., who has been appointed Chief of the Laboratory of Receptor Biology and Gene Expression. Larson’s laboratory’s goal is to understand gene expression in eukaryotic cells, starting from the mechanistic behavior of individual macromolecules and proceeding to their regulation in cells and tissue. His current work is focused on applying experimental and theoretical approaches to the study of hematopoiesis in health and disease through the trans-NIH Myeloid Malignancies Program.
Read MoreClinical trial researching immunotherapy for solid tumors
A clinical trial led by Kevin C. Conlon, M.D., Associate Research Physician in the Women’s Malignancies Branch, is researching immunotherapy for solid tumors.
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