Finding relief in the aftermath of Hurricane Maria: A patient’s journey from Puerto Rico to the National Institutes of Health

Jesus Garces-Soto and his wife, Lyssette Santiago, never expected to travel from Puerto Rico to the National Institutes of Health (NIH) in Bethesda, Maryland. On the same day that Hurricane Maria, a storm with 150-mile-per-hour winds, made direct landfall on Puerto Rico in 2017, Garces-Soto needed to seek treatment for an infection related to bladder cancer. Destruction from the hurricane took out the hospital’s electricity, and with no generator, it was difficult to provide adequate care. With help from members of the American Cancer Society and the National Cancer Institute, Garces-Soto and Santiago were flown to NIH where Garces-Soto is receiving care from Andrea Apolo, M.D., Investigator and Lasker Clinical Research Scholar in the Genitourinary Malignancies Branch. Read more...

Anupama Khare, Ph.D.

Anupama Khare joins CCR as NIH Stadtman Investigator

Posted: Dec 12, 2017

Anupama Khare, Ph.D. has joined the Laboratory of Molecular Biology as a Stadtman Tenure Track Investigator. Dr. Khare's research focuses on understanding how different microbial species co-exist in the same environmental niche and what the molecular interactions in such communities are. She is also interested in studying antibiotic persistence and identifying novel bacterial pathways that can be targeted for antimicrobial therapy in investigating the genetic basis of complex bacterial behaviors in natural environments, with an overarching goal of identifying novel targets for antibiotic therapies. Learn more...

Anupama Khare joins CCR as NIH Stadtman Investigator
Mouse bladder

Researchers studying alternative to bladder removal for bladder cancer patients

Posted: Dec 11, 2017

A new phase I clinical trial conducted by researchers at the Center for Cancer Research (CCR) is evaluating the safety and tolerability, or the degree to which any side effects can be tolerated by patients, of a two-drug combination as a potential alternative to bladder removal for bladder cancer patients. The trial targets patients with non-muscle invasive bladder cancer (NMIBC) whose cancers have stopped responding to traditional therapies. Read more...

Researchers studying alternative to bladder removal for bladder cancer patients
Everyday health logo

CCR scientists featured in Cancer Special Report 2017 from Everyday Health

Posted: Dec 7, 2017

In a recent article from Everyday Health, Elizabeth DeVita-Raeburn, Senior Editor of Oncology, details cancer trends in diagnosis, stages, treatment and survival rates. DeVita was one of 12 journalists selected by the Association of Health Care Journalists to attend a week-long reporting fellowship at the National Cancer Institute (NCI) in November 2017 to learn about the latest cancer research and participate in guided tours of NCI wards and labs. Her “Cancer Special Report 2017” discusses the latest immunology work of Steven Rosenberg, M.D., Ph.D., Chief of the Surgery Branch, and Stephanie Goff, M.D., Staff Clinician in the Surgery Branch, gene-expression profiling technique of Louis Staudt, M.D., Ph.D., Co-Chief of the Lymphoid Malignancies Branch, and new Cancer Moonshot efforts to address rare cancers, spearheaded by Mark Gilbert, M.D., Chief of the Neuro-Oncology Branch. Read the full story…

CCR scientists featured in Cancer Special Report 2017 from Everyday Health
Michael Becker

Walking with purpose after an HPV-related head and neck cancer diagnosis

Posted: Dec 6, 2017

In November 2015, Michael Becker was diagnosed with Stage IV head and neck cancer caused by a strain of the human papillomavirus, or HPV. He now advocates for education and awareness of the HPV vaccine as cancer prevention for both boys and girls. “I want to make people aware that you can avoid my situation by getting the shot.” Read more…

Walking with purpose after an HPV-related head and neck cancer diagnosis
Foregut Team

Members of NIH Foregut Team discuss new treatment options for stomach cancer

Posted: Dec 4, 2017

On Wednesday, Nov. 29, 2017, NIH Foregut Team members presented information and answered questions during a webinar on stomach cancer treatment options. Jeremy Davis, M.D., Staff Clinician in the CCR Thoracic and Gastrointestinal Oncology Branch, and Theo Heller, M.D., Senior Investigator in the National Institute of Diabetes and Digestive and Kidney Diseases, joined David Fogel, a recent total gastrectomy patient, to discuss the latest advancements in treatment. The webinar, “Navigating New Treatment Options for Gastric Cancer: Reaching above and beyond the standard of care,” was facilitated by the NIH Clinical Center and Inspire, a social network for health that connects patients and caregivers in a safe, permission-based manner. Access the recorded webinar.

Members of NIH Foregut Team discuss new treatment options for stomach cancer
Prostate cancer

Clinical trial tests precision radiotherapy for recurrent prostate cancer

Posted: Dec 4, 2017

CCR investigators are leading a trial of stereotactic body radiation therapy (SBRT) to treat localized prostate cancer that has recurred after standard radiation therapy. The technique uses advanced molecular imaging to guide the delivery of high doses of radiation just to tumors that have recurred, potentially leading to fewer side effects. Read more…

Clinical trial tests precision radiotherapy for recurrent prostate cancer
Leukemia cells

New immunotherapy approach leads to remission in patients with the most common type of childhood cancer

Posted: Nov 30, 2017

Chimeric antigen receptor (CAR) T-cell immunotherapy has emerged as a promising treatment for pre-B cell acute lymphoblastic leukemia (B-ALL), the most common type of childhood cancer. B-ALL is characterized by an overproduction of immature white blood cells called lymphoblasts. In a trial led by Center for Cancer Research investigators, around 70 to 90 percent of patients whose B-ALL has relapsed or developed resistance to chemotherapy entered remission after CAR T-cell therapy targeting CD19. Read more…

New immunotherapy approach leads to remission in patients with the most common type of childhood cancer
Dr. Claudia Palena

Claudia Palena appointed as tenured senior investigator

Posted: Nov 27, 2017

Claudia Palena, Ph.D., has been appointed as a tenured senior investigator in the Laboratory of Tumor Immunology and Biology (LTIB). Dr. Palena’s laboratory focuses on the immunological targeting of drivers of tumor dissemination and resistance to therapy. Her recent work identified the novel tumor antigen brachyury as a key factor in epithelial to mesenchymal transition (EMT), a process associated with cancer progression. More recently, Dr. Palena’s efforts have been aimed at investigating immunotherapeutic approaches that may be used alone or in combination with anti-neoplastic agents to disrupt tumor metastasis and resistance to therapy.

Claudia Palena appointed as tenured senior investigator
CAR T cells

Overactivating CAR T cells interferes with their ability to fight cancer in mice

Posted: Nov 27, 2017

CAR T-cell therapy, in which a patient’s T cells are reprogrammed in the lab to boost their ability to recognize and destroy cancer cells when they are returned to the body, has led to dramatic responses for many patients with certain blood cancers. Not all patients respond to the treatment, however, and many who do eventually relapse. Read more…

Overactivating CAR T cells interferes with their ability to fight cancer in mice
Dr. Stephanie Goff

Stephanie Goff receives American College of Surgeons Fellowship

Posted: Nov 27, 2017

Stephanie Goff, M.D., Staff Clinician in the Surgery Branch, was among 1,827 initiates from around the world who became Fellows of the American College of Surgeons (FACS) during the convocation ceremony at the college’s annual Clinical Congress on Oct. 22, 2017. According to the college, Fellows have earned the distinguished right to use the designation of “FACS” (Fellow, American College of Surgeons) after their names. Fellowship requirements include completion of advanced training in one of 14 surgical specialties, certification by an American surgical specialty board or appropriate certification by the Royal College of Physicians and Surgeons of Canada and demonstrating ethical fitness and professional proficiency. The American College of Surgeons is a scientific and educational organization of surgeons that was founded in 1913 to raise the standards of surgical practice and to improve the quality of care for the surgical patient.  

Stephanie Goff receives American College of Surgeons Fellowship

Pages