Undergraduate Research Scholar Program fellow continues her pursuit of science
Megan Andres is an NIH Undergraduate Scholarship Program (UGSP) fellow with Beverly Mock, Ph.D., Deputy Chief of the Laboratory of Cancer Biology and Genetics. The UGSP program offers competitive scholarships to students from disadvantaged backgrounds who are committed to careers in biomedical, behavioral and social science health-related research. Read more...
Trial results show that younger lymphoma patients respond well to ibrutinib
Mar 26, 2019
A recent clinical trial using the drug ibrutinib reveals that patients under age 60 with diffuse large B-cell lymphoma are much more likely to tolerate the drug – and respond to it – compared to those age 60 and older. Read more...
Louis Staudt elected as a fellow of the AACR Academy
Mar 25, 2019
Louis Staudt, M.D., Ph.D., Co-Chief of the Lymphoid Malignancies Branch, was elected to the 2019 class of fellows of the American Association for Cancer Research (AACR) Academy. The mission of the AACR Academy is to recognize and honor distinguished scientists whose major scientific contributions have propelled significant innovation and progress against cancer, and to leverage the expertise of the global brain trust of fellows of the AACR Academy to advance the mission of the AACR to prevent and cure all cancers through research, education, communication and collaboration. Read more...
New clinical trial recruits the immune system to attack chronic lymphocytic leukemia
Mar 15, 2019
Chronic lymphocytic leukemia (CLL) is cancer that develops in blood-forming cells in the bone marrow. A new clinical trial is testing a way to boost the body’s natural immune cells and recruit them to attack and kill marked leukemia cells. Read more...
CCR researchers discover how protein translation disruptions can lead to cancer
Mar 11, 2019
A mutation in the gene U2AF1, which codes for a protein involved in cutting out key pieces of RNA, can also have widespread effects on the translation of messenger RNA into proteins. A close look at one affected protein, interleukin 8 (IL8), revealed increased production as a result of the mutation, leading to inflammation and cancer spread. Read more...
Drug found effective in mice for uveal melanoma
Mar 6, 2019
Drugs that directly target the transcription factor YAP, which is associated with the growth of uveal melanoma, are too toxic to be used in patients. A new study in mice, however, finds a new, safe and effective way for targeting the YAP pathway. Read more...
Elaine Jaffe inducted as honorary fellow of the Royal College of Pathology of Australasia
Mar 4, 2019
Elaine Jaffe, M.D., Senior Investigator in the Laboratory of Pathology, was recently inducted as an honorary fellow of the Royal College of Pathology of Australasia. The fellowship recognizes the work and publications of a haematophathologist that have influenced and improved haematopathology practice worldwide. Read more...
CCR Presentations at AACR - 2019
Feb 27, 2019
The American Association for Cancer Research (AACR) Annual Meeting covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world. The 2019 AACR Meeting, "Integrative Cancer Science • Global Impact • Individualized Patient Care", will be held in Atlanta, between March 29 - April 3, 2019. View the list of CCR presentations...
From father to daughter: A bone marrow transplant for GATA2 deficiency
Feb 26, 2019
James and Jahleel are a father-daughter duo from Tennessee who came to NIH for Jahleel’s bone marrow transplant. Jahleel was diagnosed with GATA2 deficiency, a rare genetic disease that causes a wide range of symptoms, including myeloid leukemias. Read more...
Deep-imaging study reveals extensive variability in 3D configuration of genomes between cells
Feb 21, 2019
A new study analyzing chromatin in single cells using advanced imaging methods, led by CCR Director Tom Misteli, Ph.D., has revealed more heterogeneity in the 3D configuration of genomes than previously thought. Read more...
New strategy for treating brain tumors with mutations in metabolic enzymes
Feb 20, 2019
Cancers with mutations in key metabolic enzymes disrupt oxygen metabolism and cause a buildup of reactive oxygen species in mice. This mutation is found in about 80 percent of grade II/III gliomas, or brain tumors, in humans. By inhibiting the action of a protein that allows cancer cells to survive, investigators have potentially found a new strategy for treating cancers with these mutations. Read more...