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Immunofluorescence image of the cell adhesion protein basigin (turquoise) in TuNEPs released from dying 4T1 mouse breast cancer cells.

Proteins Released from the Nuclei of Dying Cancer Cells Promote Tumor Growth

Material released from dying cancer cells, known as tumor cell nuclear expulsion products (TuNEPs), contains specific proteins that promote the growth of neighboring cancer cells. Targeting these proteins could lead to new treatments that hinder cancer spread and improve patient outcomes.

An illustration of immune cells with zeroes and ones, representing CIDE, a new, large-scale immuno-oncology data platform.

Cancer Immunology Data Engine uncovers secreted proteins with therapeutic potential

CCR researchers have developed a new tool that identifies secreted proteins associated with immunotherapy outcomes.

Graphic depiction of near-infrared photoimmunotherapy (NIR-PIT) targeted against ICAM-1 markers (small, blue, Y-shaped), causing cancer cell death and suppressed tumor growth (pink cluster, center).

CCR-developed cancer therapy shrinks tumors and boosts immune response

A targeted cancer therapy developed at CCR shows promise in its ability to target a common cancer cell marker, both shrinking tumors and producing a boosted immune response.

Clinical trial researching drug therapy for colorectal cancer

A clinical trial led by Tim F. Greten, M.D., Deputy Chief and Senior Investigator in the Thoracic and GI Malignancies Branch, is researching a two-drug therapy for adults with metastatic colorectal cancer.

A graphic depiction of the dimethoxyphenyl cyanoacrylamide (DiMe) chemical warhead facilitating reversible binding of drug to its molecular target.

Synthesized chemical component helps cancer drugs remain stable in water

Researchers developed a new chemical component that can be attached to drug molecules to make them more stable in water without losing effectiveness. This innovation could improve the performance of some cancer treatments.

Clinical trial researching immunotherapy for mesothelioma

A clinical trial led by Raffit Hassan, M.D., Chief and Senior Investigator in the Thoracic and GI Malignancies Branch, is researching an immunotherapy treatment for adults with solid tumors, including mesothelioma.

Doctor with patient. Image credit: Canva

Clinical trial researching drug therapy for multiple myeloma

A clinical trial led by Elizabeth M. Hill, M.D., Assistant Research Physician in the Lymphoid Malignancies Branch, is researching a combination drug therapy for myeloid malignancies.

Combining bevacizumab with erlotinib shrinks tumors in patients with rare and aggressive kidney cancer

Seventy-two percent of patients with HLRCC-associated kidney cancers, for which there previously was no known drug treatment, responded to the therapy in a clinical trial.

Celebrating CCR Careers: Yves Pommier, M.D., Ph.D.

Yves Pommier, M.D., Ph.D., is a molecular pharmacologist who has done pioneering work on the mechanisms of topoisomerase and PARP inhibition as well as on the discovery of novel biomarkers for anticancer drug responses. After 45 years at the NIH, he is announcing his retirement.

Celebrating CCR Careers: Zhengping Zhuang, M.D., Ph.D.

Zhengping Zhuang, M.D., Ph.D., is a world-renowned expert in experimental pathology, cancer genetics and cancer therapeutics. He has contributed to biotechnological advancements, drug development and clinical translation of his work in tumor biology. After 32 years serving the NCI, he has announced his retirement.

Acute myeloid leukemia. Image credit: iStock

Researchers uncover why a leukemia treatment can cause problems with movement and balance

Ara-C, also known as cytarabine, is the most common chemotherapy to cause cerebellar toxicity. Researchers discovered how the treatment leaves certain neurons with double-strand breaks in their DNA.

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