News and Events
Celebrating CCR Careers: R. Andrew Byrd, Ph.D.
32 years ago, R. Andrew Byrd, Ph.D., came to NCI Frederick to study the foundational biophysics of cancer. After an extensive career developing and utilizing nuclear magnetic resonance (NMR) spectroscopy methods to determine protein structures and mechanistic insight, he has announced his retirement.
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Undergraduate Research Scholar Program fellow continues her pursuit of science
Megan Andres is an NIH Undergraduate Scholarship Program (UGSP) fellow with Beverly Mock, Ph.D., Deputy Chief of the Laboratory of Cancer Biology and Genetics. The UGSP program offers competitive scholarships to students from disadvantaged backgrounds who are committed to careers in biomedical, behavioral and social science health-related research. She is hoping to make a difference in possible treatment options for children with Burkitt lymphoma.
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New clinical trial tests radiotracer for improved imaging of metastatic prostate cancer
Most forms of prostate cancer have receptors for prostate-specific membrane antigen (PSMA), a protein that helps fuel the development of prostate cancer cells. Investigators are studying if a radiotracer that binds to PSMA may improve imaging methods to find sites of metastatic prostate cancer.
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Clinical trial tests a PARP inhibitor in urothelial cancer with DNA-repair defects
Urothelial carcinoma (UC), or bladder cancer, is the most common cancer of the urinary tract with limited treatment options. A new clinical trial aims to see how this type of cancer reacts to olaparib, a drug designed to target cancers that have defective DNA-repair mechanisms in their cells by inhibiting the action of PARP, an enzyme that can repair breaks in DNA.
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African Postdoctoral Training Initiative fellow looks forward to collaborating within NCI
Rania Labib, Ph.D., is a postdoctoral fellow in the NIH African Postdoctoral Training Initiative (APTI) working in the lab of Beverly Mock, Ph.D., Deputy Chief of the Laboratory of Cancer Biology and Genetics. As part of the fellowship, she will spend two years at NCI conducting initial experiments in Dr. Mock’s lab, where she hopes to make a difference in possible treatment options for children with Burkitt’s lymphoma.
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Envelope glycoprotein mutations allow HIV-1 to escape antiretroviral therapy in a lab-based study
CCR investigators have discovered that HIV-1 can compensate for a variety of mutations that block its replication by acquiring mutations in the envelope glycoprotein. Because antiretroviral therapies work by inhibiting viral replication, these findings may have implications for HIV-1 drug resistance.
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MEK inhibitor selumetinib granted breakthrough designation by FDA to treat neurofibromatosis type 1 in pediatric patients
The U.S. Food and Drug Administration last week granted breakthrough therapy designation for the MEK 1/2 inhibitor selumetinib. The designation is for the treatment of pediatric patients aged three years and older with neurofibromatosis type 1 (NF1) symptomatic and/or progressive, inoperable plexiform neurofibromas (PN), a rare, incurable genetic condition.
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Elaine Jaffe receives the 2019 USCAP Board’s Distinguished Pathologist award
Elaine Jaffe, M.D., Senior Investigator in the Laboratory of Pathology, has received the 2019 United States and Canadian Academy of Pathology (USCAP) Board’s Distinguished Pathologist award. The award recognizes an individual for making major contributions to pathology over the years.
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New study delivers chemotherapy to the liver for metastatic colorectal cancer patients
In some patients, colorectal cancer spreads only to the liver. Patients with previously treated colorectal cancer that has spread only to the liver may be eligible to participate in a new clinical trial at the NIH Clinical Center.
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CCR staff receive funding from the Department of Defense
Congratulations to the CCR staff who have received funding from the Department of Defense (DoD) Congressionally Directed Medical Research Program (CDMRP). The CDMRP office manages medical research programs in breast, prostate and ovarian cancers, neurofibromatosis, military health and other specified areas.
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Stephanie Goff featured in an episode of The Doctors
Stephanie Goff, M.D., Associate Research Physician in CCR’s Surgery Branch, was recently featured on The Doctors. In the clip, she discusses how harnessing the body’s own immune system and adoptive cell transfer (ACT) can treat certain types of cancer.
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