Terry P. Yamaguchi, Ph.D.

Terry P. Yamaguchi, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Yamaguchi studies how intercellular signals control embryonic development. His recent studies of the Wnt family of signaling molecules have provided a new understanding of how Wnts regulate the transcription of target genes to control the fate of embryonic and adult stem cells.

Dr. Yamaguchi’s lab emphasizes innovative genetic and genome-wide approaches to elucidate the gene regulatory networks that transduce Wnt signals in stem cells, and is developing new animal models of Wnt pathway-dependent intestinal tumorigenesis.

Areas of Expertise

1) embryology, 2) stem cell, 3) Wnt, 4) transcription factors, 5) intestinal tumorigenesis, 6) genomics


Selected Recent Publications

A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation

Garriock RJ, Chalamalasetty RB, Zhu J, Kennedy MW, Kumar A, Mackem S, Yamaguchi TP.
Development. 147(8): dev185108, 2020. [ Journal Article ]

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking

Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP, Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP, Shimono A, Shiratori H, Hamada H.
Dev Cell. 40(5): 439-52, 2017. [ Journal Article ]

Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription

Kennedy MW, Chalamalasetty RB, Thomas S, Garriock RJ, Jailwala P, Yamaguchi TP
Proc Natl Acad Sci U S A. 113(13): 3545-50, 2016. [ Journal Article ]

Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex

Kumar A, Chalamalasetty RB, Kennedy MW, Thomas S, Inala SN, Garriock RJ, Yamaguchi TP.
Mol Cell Biol. 36(12): 1793-802, 2016. [ Journal Article ]

Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation

Garriock RJ, Chalamalasetty RB, Kennedy MW, Canizales LC, Lewandoski M, Yamaguchi TP
Development. 142(9): 1628-38, 2015. [ Journal Article ]

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