Ravi B. Chalamalasetty, Ph.D.

Ravi B. Chalamalasetty, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Research in cancer biology and developmental biology have greatly benefitted from each other’s progress over the past few decades. A closer look reveals that many of the molecular and cellular processes essential for the normal embryonic development are mis-regulated in cancer progression. In our lab, we are specifically interested in understanding the molecular mechanisms that regulate tissue homeostasis. A delicate balance of stem cell self-renewal and differentiation is required for the maintenance of normal embryonic structures, adult organogenesis, and wound repair. However, the molecular, genetic and cellular cues essential for this biological process are not very clear. We are utilizing a variety of approaches from molecular biology, mouse genetics, embryonic development, embryonic stem cell differentiation, functional genomics and bioinformatics to address these questions.

Areas of Expertise

Embryonic Development
Embryonic Stem Cells
Mouse Genetics
Wnt Signaling
Transcription Factors


Selected Key Publications

A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation

Garriock RJ*, Chalamalasetty RB*, Zhu J, Kennedy MW, Kumar A, Mackem S, Yamaguchi TP.
Development. 2020 Apr 12;147(8): dev185108, 2020.
Full-Text Article
[ Journal Article ]

Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex

Kumar A*, Chalamalasetty RB*, Kennedy MW, Thomas S, Inala SN, Garriock RJ, Yamaguchi TP.
Mol Cell Biol. 2016 May 31;36(12): 1793-802, 2016.
Full-Text Article
[ Journal Article ]

Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription

Kennedy MW, Chalamalasetty RB, Thomas S, Garriock RJ, Jailwala P, Yamaguchi TP.
Proc Natl Acad Sci U S A. Mar 29;113(13): 3545-50, 2016. [ Journal Article ]

Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation

Chalamalasetty RB, Garriock RJ, Dunty WC Jr, Kennedy MW, Jailwala P, Si H, Yamaguchi TP.
Development. 141(22): 4285-97, 2014. [ Journal Article ]

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP.
Nat Commun. 2: 390, 2011. [ Journal Article ]