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Ravi B. Chalamalasetty, Ph.D.

Ravindra B. Chalamalasetty, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Research in cancer biology and developmental biology have greatly benefitted from each other’s progress over the past few decades. A closer look reveals that many of the molecular and cellular processes essential for the normal embryonic development are mis-regulated in cancer progression. In our lab, we are specifically interested in understanding the molecular mechanisms that regulate tissue homeostasis. A delicate balance of stem cell self-renewal and differentiation is required for the maintenance of normal embryonic structures, adult organogenesis, and wound repair. However, the molecular, genetic and cellular cues essential for this biological process are not very clear. We are utilizing a variety of approaches from molecular biology, mouse genetics, embryonic development, embryonic stem cell differentiation, functional genomics and bioinformatics to address these questions.

Areas of Expertise

Embryonic Development
Embryonic Stem Cells
Organoids
Wnt Signaling
Mouse Genetics
Cancer Signaling and Pathways

Publications

Selected Key Publications

Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

Chalamalasetty RB, Tran H, Kelly R, Kuo S, Kennedy MW, Lee M, Thomas S, Mandalos, N, Koparde V, Lobo FP, Yamaguchi TP.
BioRxiv. 2025.
Full-Text Article
[ Journal Article ]

Transcription factors Sp5 and Sp8 drive primary cilia formation

Liang Y, Koche R, Chalamalasetty RB, Stephen DN, Kennedy, MW, Lao, Z, Pang, Y, Kuo YY, Lee M, Lobo, FP, Huang X, Hadjantonakis AK, Yamaguchi TP, Anderson KV, Joyner AL.
Science, accepted. 2025.
Full-Text Article
[ Journal Article ]

A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation

Garriock RJ*, Chalamalasetty RB*, Zhu J, Kennedy MW, Kumar A, Mackem S, Yamaguchi TP.
Development. 2020 Apr 12;147(8): dev185108, 2020.
Full-Text Article
[ Journal Article ]

Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation

Chalamalasetty RB, Garriock RJ, Dunty WC Jr, Kennedy MW, Jailwala P, Si H, Yamaguchi TP.
Development. 141(22): 4285-97, 2014.
Full-Text Article
[ Journal Article ]

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

Chalamalasetty RB, Dunty WC Jr, Biris KK, Ajima R, Iacovino M, Beisaw A, Feigenbaum L, Chapman DL, Yoon JK, Kyba M, Yamaguchi TP.
Nat Commun. 2: 390, 2011.
Full-Text Article
[ Journal Article ]