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Douglas R. Lowy, M.D.

Douglas R. Lowy, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

 As Laboratory Chief, Dr. Lowy’s two main research areas focus on basic and translational aspects of human papillomavirus infection and on cancer genes. His joint research with John Schiller in the Laboratory of Cellular Oncology (LCO) has identified many aspects of the human papillomavirus (HPV) life cycle, developed technology underlying the FDA-approved HPV vaccines, and elucidated mechanisms for the high efficacy of the vaccines. Secondly, his research is currently examining the DLC1 tumor suppressor, which encodes a Rho-GAP that is down-regulated in a wide variety of cancers, leading to the high Rho activity seen in many advanced cancers. This research has identified important scaffold functions for DLC1, including protein-protein interactions that contribute to the regulation of its activity and its role as a tumor suppressor, and identified kinases that activate and inactivate the functions of DLC1 and the mechanisms by which they do so.

Areas of Expertise

1) cancer biology 2) papillomaviruses 3) preventive vaccines 4) Rho GTPases 5) signaling 6) tumor suppressor genes

Publications

Selected Recent Publications

DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis

Ritchey L, Ha T, Otsuka A, Kabashima K, Wang D, Wang Y, Lowy DR, Tosato G.
Oncogene. 38(45): 7046-59, 2019. [ Journal Article ]

SRC and ERK cooperatively phosphorylate DLC1 and attenuate its Rho-GAP and tumor suppressor functions

Tripathi BK, Anderman MF, Qian X, Zhou M, Wang D, Papageorge AG, Lowy DR.
J Cell Biol. 218(9): 3060-76, 2019. [ Journal Article ]

A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells

Çuburu N, Kim R, Guittard GC, Thompson CD, Day PM, Hamm DE, Pang YS, Graham BS, Lowy DR, Schiller JT.
J Immunol. 202(4): 1250-64, 2019. [ Journal Article ]

Human papillomavirus capsids preferentially bind and infect tumor cells

Kines RC, Cerio RJ, Roberts JN, Thompson CD, de Los Pinos E, Lowy DR, Schiller JT.
Int J Cancer. 138: 901-11, 2016. [ Journal Article ]

Efficient Production of Papillomavirus Gene Delivery Vectors in Defined In Vitro Reactions

Cerqueira C, Thompson CD, Day PM, Pang YS, Lowy DR, Schiller JT.
Mol Ther Methods Clin Dev . 5: 165-179, 2017. [ Journal Article ]

Job Vacancies

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Team

Research Biologist
Marian Durkin, Ph.D.
Research Biologist
Richard Koller, B.S.
Research Biologist
Alex G. Papageorge, M.S.
Postbaccalaureate fellow (IRTA/CRTA)
Ashley Hwa-Young Lim
Postbaccalaureate fellow (IRTA/CRTA)
David Christopher Hansen