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Dr. Xiaolan Qian M.D., Ph.D.

Xiaolan Qian, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 37, Room 4112
  • Bethesda, MD 20892-4263
  • 240-760-7925
  • 301-594-3996
  • qianx@mail.nih.gov

RESEARCH SUMMARY

Dr. Qian’s major research interests have focused on the impact of certain oncogenes and tumor suppressor genes on normal and neoplastic cell growth and signaling. Her recent studies have included the use of cell biological approaches to understand growth and signaling differences that result from the perturbation of protein kinases (Her-2, EGFR, Src, FAK, Cdk4/6), tumor suppressors (DLC1, p15/p16), cell-cell adhesions (E-cadherin), focal adhesions (talin, tensin, vinculin, paxillin, integrins), and the regulation of small GTPases (Ras, Rap, Rho, Cdc42) by oncogenic GEFs or tumor suppressive GAPs.

Areas of Expertise

1) cancer biology 2) cell and molecular biology 3) tumor suppressor genes and oncogenes 4) protein kinases 5) post-translational regulation 6) regulation of small GTPases by GEFs and GAPs

Publications

Selected Publications

E-cadherin-mediated adhesion inhibits ligand-dependent activation of diverse receptor tyrosine kinases

Qian X, Karpova T, Sheppard AM, McNally J, Lowy DR.
EMBO J.. 23: 1739-48, 2004. [ Journal Article ]

Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer

Qian X, Durkin ME, Wang D, Tripathi BK, Olson L, Yang XY, Vass WC, Popescu NC, Lowy DR.
Cancer Res.. 72: 5900-11, 2012. [ Journal Article ]

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

Li G, Du X, Vass WC, Papageorge AG, Lowy DR, Qian X.
Proc. Natl. Acad. Sci. U.S.A.. 108: 17129-34, 2011. [ Journal Article ]

The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis

Qian X, Li G, Vass WC, Papageorge A, Walker RC, Asnaghi L, Steinbach PJ, Tosato G, Hunter K, Lowy DR.
Cancer Cell. 16: 246-58, 2009. [ Journal Article ]

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

Qian X, Li G, Asmussen HK, Asnaghi L, Vass WC, Braverman R, Yamada KM, Popescu NC, Papageorge AG, Lowy DR.
Proc. Natl. Acad. Sci. U.S.A.. 104: 9012-7, 2007. [ Journal Article ]