Breadcrumb

Photo of Brajendra Tripathi using confocal microscope

Brajendra Tripathi, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Tripathi has an abiding interest in the clinical applications of basic research. His current research is mainly focused on how tumor suppressor proteins, which are downregulated or inactivated in several cancer types by distinct mechanisms, can be stabilized and reactivated and exploited for cancer treatment. Specifically, Dr. Tripathi and colleagues are exploring functions of the tumor suppressor protein Deleted in Liver Cancer 1 (DLC1) and the kinases and methyltransferases that regulate its functions in normal physiology and in cancer.

Areas of Expertise

1) cancer biology 2) cell biology and cell imaging 3) small GTPases signaling 4) oncogenes and tumor suppressor genes regulation 5) protein kinases and post-translational modifications

News

Dr. Tripathi is featured in the ‘People and Ideas’ section of the Journal of Cell Biology.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781442/

Dr. Tripathi and colleagues research is featured in the special issue “Cancer Cell Biology 2020” of the Journal of Cell Biology: SRC targets the tumor suppressor DLC1: Interaction between DLC1 and tumor promoting kinase SRC reveals a possible new treatment route for DLC1-positive tumors.