Zheng-Gang  Liu, Ph.D.

Zheng-Gang Liu, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Liu is a renowned researcher in the fields of tumor necrosis factor (TNF) signaling and the regulation of apoptosis and necrosis. He made several seminal findings to the current understanding of TNF signaling and the mechanisms of cell death. For instance, his lab demonstrated that RIP1 cleavage by Casp-8 is a key regulator of TNF signaling and that MLKL is an essential component of TNF-induced necrosis. More recently, his lab has also worked on the role of inflammation in tumorigenesis and the regulation of macrophage differentiation.

Areas of Expertise


Selected Key Publications

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi, Zheng-Gang Liu
Nature Commun.. 12(1): 2666, 2021. [ Journal Article ]

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang XM, Liu ZG.
Cell Res. 26(8): 886-900, 2016. [ Journal Article ]

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
Nat Cell Biol. 16(1: 55-65, 2014. [ Journal Article ]

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG
Proc Natl Acad Sci U S A. 109(14): 5322-7, 2012. [ Journal Article ]

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.

Lin Y, Devin A, Rodriguez Y, Liu ZG
Genes Dev. 13(19): 2514-26, 1999. [ Journal Article ]

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research Fellow
Jiong Yan, Ph.D.
research fellow
Zhao-Shan Liu, Ph.D.
Postdoctoral fellow
Sahar Foroutannejad, PhD
Postdoctoral Fellow (Visiting)
Peixing Wan, Ph.D.
visiting fellow
Xin Chen, PhD
visiting fellow
Yeonji Park, PhD
Postbaccalaureate Fellow
Ruwaida Rajna
animal technician
Juan Morales-Contreras


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