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Zheng-Gang  Liu, Ph.D.

Zheng-Gang Liu, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Immune Cell Biology

RESEARCH SUMMARY

Dr. Liu is a renowned researcher in the fields of tumor necrosis factor (TNF) signaling and the regulation of apoptosis and necrosis. He made several seminal findings to the current understanding of TNF signaling and the mechanisms of cell death. For instance, his lab demonstrated that RIP1 cleavage by Casp-8 is a key regulator of TNF signaling and that MLKL is an essential component of TNF-induced necrosis. More recently, his lab has also worked on the role of inflammation in tumorigenesis and the regulation of macrophage differentiation.

Areas of Expertise

Publications

Selected Key Publications

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi, Zheng-Gang Liu
Nature Commun.. 12(1): 2666, 2021. [ Journal Article ]

Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang XM, Liu ZG.
Cell Res. 26(8): 886-900, 2016. [ Journal Article ]

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
Nat Cell Biol. 16(1: 55-65, 2014. [ Journal Article ]

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG
Proc Natl Acad Sci U S A. 109(14): 5322-7, 2012. [ Journal Article ]

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.

Lin Y, Devin A, Rodriguez Y, Liu ZG
Genes Dev. 13(19): 2514-26, 1999. [ Journal Article ]

Job Vacancies

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Team

Research Fedllow
Jin Young Baik, Ph.D.
Postdoctoral fellow
Sahar Foroutannejad, PhD
Postbaccalaureate Fellow
Stephen Leyva, B.S.
Postbaccalaureate Fellow (iCURE/IRTA)
Dana Van Fossen
Postdoctoral Fellow (Visiting)
Zhao-Shan Liu, Ph.D.
Postdoctoral Fellow (Visiting)
Peixing Wan, Ph.D.
research Fellow
Jiong Yan, Ph.D.
animal technician
Juan Morales-Contreras

News

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