Swati S. Choksi, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 1130
- Bethesda, MD 20892
Dr. Swati Choksi is a Staff Scientist in the Laboratory of Immune Cell Biology at the National Cancer Institute, NIH. She is interested in cell death and the fine balance of apoptosis, necrosis and autophagy that regulates the fate of a cell. Her current work is focused on connecting cell death pathways to tumorigenesis.
Areas of Expertise
1) apoptosis 2) necrosis 3) TNF signaling 4) mouse tumor models
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Butylated hydroxyanisole blocks the occurrence of tumor associated macrophages in tobacco smoke carcinogen-induced lung tumorigenesis
ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages
Induction of autophagy is essential for monocyte-macrophage differentiation
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
Swati S. Choksi, Ph.D.
Dr. Swati Choksi is a Staff Scientist in the Laboratory of Genitourinary Cancer Pathology at the the National Cancer Institute, NIH. She received her Ph.D. and training in the Department of Immunology, Kimmel Cancer Center, Thomas Jefferson University. Her thesis work involved molecular modeling of peptide mimics of CD8 and develop therapeutics for graft versus host disease. These studies led to several patents. Dr. Choksi is currently interested in cell death and the fine balance of apoptosis, necrosis and autophagy that regulates the fate of a cell. Her current work is focused on connecting cell death pathways to tumorigenesis. Dr. Choksi is active in the NIH scientific community. She is a member of the CCR Staff Scientist/Staff Clinician (SSSC) Organization and has been very giving of her time by serving on many committees for the SSSC Organization since first becoming a staff scientist in 2008. She has and continues to serve on the Retreat Planning Committee, Social Networking Committee and the Professional Development Committee. Dr. Choksi is involved with the Immunology Interest Group, NIH by attending lectures and the annual retreat. Dr. Choksi also volunteers her time and experience to judge abstracts/posters for F.A.R.E. and the SSSC.