Ira O. Daar, Ph.D.

Ira O. Daar, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


In our laboratory, we focus on the Eph/ephrin signaling system, and specifically how the ephrinB transmembrane ligands for Eph receptor tyrosine kinases send signals affecting cell-cell junctions and cell movement. This signaling intersects with the Wnt/PCP (Planar Cell Polarity) pathway to affect morphogenesis during development and has been shown to play an instructive role in angiogenesis, as well as tumor cell invasion.

Areas of Expertise

Cell-Cell Adhesion
Cell Migration


Selected Recent Publications

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling

Yoon J, Sun J, Lee M, Hwang YS, Daar IO
Nature Communications. 14(1): 337, 2023.
Full-Text Article
[ Journal Article ]

Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery

Zhao H, Sun J, Insinna C, Lu Q, Wang Z, Nagashima K, Stauffer J, Andresson T, Specht S, Perera S, Daar IO, Westlake CJ.
EMBO Reports. e52775, 2022.
Full-Text Article
[ Journal Article ]

Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development

Sun J, Yoon J, Lee M, Lee HK, Hwang YS, Daar IO.
Cell Reports. 38: 110312, 2022.
Full-Text Article
[ Journal Article ]

CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis

Lee M, Nagashima K, Yoon J, Sun J, Wang Z, Carpenter C, Lee HK, Hwang YS, Westlake CJ, Daar IO
Journal of Cell Biology. 221/1: e202102110, 2022.
Full-Text Article
[ Journal Article ]

Rab11fip5 regulates telencephalon development via ephrinB1 recycling

Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO
Development. 148: dev196527. doi: 10.1242/dev.196527, 2021.
Full-Text Article
[ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - Ephrin/Eph Signaling in Lung Development and Regeneration Ph.D. or equivalent Ira Daar, Ph.D.


Jaeho Yoon, Ph.D.

Congratulations to Jaeho Yoon and crew for publishing another beautiful story in Nature Communications   Yoon J*, Sun J, Lee M, Hwang YS, Daar IO*  2023.

Further Congrats on the paper "Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling" being selected to be highlighted in the Editors' Choice section of Science Signaling, a weekly journal from the publisher of Science magazine. A link to the summary of your article is below: