Breadcrumb

Ira O. Daar, Ph.D.

Ira O. Daar, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

In our laboratory, we focus on the Eph/ephrin signaling system, and specifically how the ephrinB transmembrane ligands for Eph receptor tyrosine kinases send signals affecting cell-cell junctions and cell movement. This signaling intersects with the Wnt/PCP (Planar Cell Polarity) pathway to affect morphogenesis during development and has been shown to play an instructive role in angiogenesis, as well as tumor cell invasion.

Areas of Expertise

1) Xenopus embryogenesis 2) development 3) signal transduction 4) Eph/ephrin 5) cell-cell adhesion 6) cell migration

Publications

Selected Recent Publications

Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery

Zhao H, Sun J, Insinna C, Lu Q, Wang Z, Nagashima K, Stauffer J, Andresson T, Specht S, Perera S, Daar IO, Westlake CJ.
EMBO Reports. e52775, 2022.
Full-Text Article
[ Journal Article ]

Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development

Sun J, Yoon J, Lee M, Lee HK, Hwang YS, Daar IO.
Cell Reports. 38: 110312, 2022.
Full-Text Article
[ Journal Article ]

CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis

Lee M, Nagashima K, Yoon J, Sun J, Wang Z, Carpenter C, Lee HK, Hwang YS, Westlake CJ, Daar IO
Journal of Cell Biology. 221/1: e202102110, 2022.
Full-Text Article
[ Journal Article ]

Rab11fip5 regulates telencephalon development via ephrinB1 recycling

Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO
Development. 148: dev196527. doi: 10.1242/dev.196527, 2021.
Full-Text Article
[ Journal Article ]

Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled

Lee M, Hwang YS, Yoon J, Sun J, Harned A, Nagashima K, and Daar IO
Journal of Cell Biology. 218 issue 8: 2019.
Full-Text Article
[ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postdoctoral Fellow (Visiting)
Jian Sun, Ph.D.
Predoctoral Visiting Fellow (Graduate Student), UMD-NCI Partnership for Integrative Cancer Research
Leena Pade, M.S.