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Ira O. Daar, Ph.D.

Ira O. Daar, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Senior Investigator
Head, Developmental Signal Transduction Section

RESEARCH SUMMARY

In our laboratory, we focus on the Eph/ephrin signaling system, and specifically how the ephrinB transmembrane ligands for Eph receptor tyrosine kinases send signals affecting cell-cell junctions and cell movement. This signaling intersects with the Wnt/PCP (Planar Cell Polarity) pathway to affect morphogenesis during development and has been shown to play an instructive role in angiogenesis, as well as tumor cell invasion.

Areas of Expertise

Eph/ephrin
Cell-Cell Adhesion
Cell Migration

Publications

Selected Recent Publications

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling

Yoon J, Sun J, Lee M, Hwang YS, Daar IO
Nature Communications. 14(1): 337, 2023.
Full-Text Article
[ Journal Article ]

Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery

Zhao H, Sun J, Insinna C, Lu Q, Wang Z, Nagashima K, Stauffer J, Andresson T, Specht S, Perera S, Daar IO, Westlake CJ.
EMBO Reports. e52775, 2022.
Full-Text Article
[ Journal Article ]

Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development

Sun J, Yoon J, Lee M, Lee HK, Hwang YS, Daar IO.
Cell Reports. 38: 110312, 2022.
Full-Text Article
[ Journal Article ]

CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis

Lee M, Nagashima K, Yoon J, Sun J, Wang Z, Carpenter C, Lee HK, Hwang YS, Westlake CJ, Daar IO
Journal of Cell Biology. 221/1: e202102110, 2022.
Full-Text Article
[ Journal Article ]

Rab11fip5 regulates telencephalon development via ephrinB1 recycling

Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO
Development. 148: dev196527. doi: 10.1242/dev.196527, 2021.
Full-Text Article
[ Journal Article ]

Job Vacancies

We have no open positions in our group at this time, please check back later.

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Team

Post-Baccalaurate Fellow
Anthea Luo, B.A.
Werner H. Kirsten Student Intern Program
Sawyer Grunwell
Werner H. Kirsten Student Intern Program
Olivia Thomas
Summer Cancer Research Training Award Fellow - Former WHK
Olivia Bindewald
Summer Cancer Research Training Award - Former WHK
Elizabeth Goodwin

News

Image
Jaeho Yoon, Ph.D.

Congratulations to Jaeho Yoon and crew for publishing another beautiful story in Nature Communications   Yoon J*, Sun J, Lee M, Hwang YS, Daar IO*  2023.

https://www.nature.com/articles/s41467-023-35991-6

Further Congrats on the paper "Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling" being selected to be highlighted in the Editors' Choice section of Science Signaling, a weekly journal from the publisher of Science magazine. A link to the summary of your article is below:

https://www.science.org/doi/10.1126/scisignal.adg8489