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Jaeho Yoon, Ph.D.

Jaeho Yoon, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Yoon has been interested in the planar cell polarity (PCP) in his preferred animal model, the developing Xenopus embryo. Polarized cellular behaviors that are governed by PCP signaling represent a vital process for orchestrating cells to form a distinct polarity axis in a tissue. This PCP signaling is driven by various stimuli such as spatial/temporal gene expression, Wnt morphogen gradients and asymmetric subcellular enrichment of PCP proteins. Since abnormal regulation of PCP signaling causes severe birth defects and defects of tissue function, the PCP process has been known as an essential feature for proper embryo development and diverse functions in many tissues. Aberrant Wnt/PCP signaling has been strongly implicated in cancer progression.

Areas of Expertise

1) Xenopus embryogenesis, 2) Signal transduction, 3) Eph/ephrin, 4) planar cell polarity (PCP), 5) Cell migration, 6) Cranial neural crest (CNC) development

Publications

Selected Publications

Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling.

Jaeho Yoon, Jian Sun, Moonsup Lee, Yoo-Seok Hwang & Ira O. Daar
Nature Communications. 20;14(1):337: 2023.
Full-Text Article
[ Journal Article ]

TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration

Yoon J, Hwang YS, Lee M, Sun J, Cho HJ, Knapik L, Daar IO
Nat Commun. 9(1):3491: 2018.
Full-Text Article
[ Journal Article ]

Rab11fip5 regulates telencephalon development via ephrinB1 recycling.

Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO
Development. 148(3): 2021.
Full-Text Article
[ Journal Article ]

Characterization of a Compound Heterozygous SLC2A9 Mutation That Causes Hypouricemia.

Yoon J, Cachau R, David VA, Thompson M, Jung W, Jee SH, Daar IO, Winkler CA, Cho SK
Biomedicines. 9(9): 2021.
Full-Text Article
[ Journal Article ]

Bmp Signal Gradient Modulates Convergent Cell Movement via Xarhgef3.2 during Gastrulation of Xenopus Embryos

Jaeho Yoon, Vijay Kumar, Ravi Shankar Goutam , Sung-Chan Kim, Soochul Park, Unjoo Lee and Jaebong Kim
Cells. 11(1), 44: 2021.
Full-Text Article
[ Journal Article ]

Team