Ryan M. Young, Ph.D.

Ryan M. Young, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Lymphoid Malignancies Branch


Dr. Young employs proteogenomic technologies to elucidate novel modes of pathogenic signaling in multiple myeloma and lymphoma. Insights from his research are helping to identify novel therapeutic targets and to exploit druggable pathways in lymphoid malignancies.

Areas of Expertise


Selected Publications

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W Wright, James D Phelan, Da Wei Huang, James W Lord, Callie K Van Winkle, Xin Yu, Jan Wisniewski, James Q Wang, Frances A Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J Thomas, Ryan M Young
nature communications. 13 (1): 5469, 2022.
Full-Text Article
[ Journal Article ]

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.
Nature. 560(7718): 387-91, 2018. [ Journal Article ]

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens

Young RM, Wu T, Schmitz R, Dawood M, Xiao W, Phelan JD, Xu W, Menard L, Meffre E, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Staudt LM.
Proc Natl Acad Sci U S A. 112(44): 13447-54, 2015. [ Journal Article ]

Oncogenically active MYD88 mutations in human lymphoma

Vu N Ngo, Ryan M Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian-Huat Lim, Holger Kohlhammer, Weihong Xu, Yandan Yang, Hong Zhao, Arthur L Shaffer, Paul Romesser, George Wright, John Powell, Andreas Rosenwald, Hans Konrad Muller-Hermelink, German Ott, Randy D Gascoyne, Joseph M Connors, Lisa M Rimsza, Elias Campo, Elaine S Jaffe, Jan Delabie, Erlend B Smeland, Richard I Fisher, Rita M Braziel, Raymond R Tubbs, JR Cook, Denny D Weisenburger, Wing C Chan, Louis M Staudt
Nature. 470 (7332): 115-119, 2011.
Full-Text Article
[ Journal Article ]

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