Ryan M. Young, Ph.D.

Ryan M. Young, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Lymphoid Malignancies Branch


Dr. Young employs proteogenomic technologies to elucidate novel modes of pathogenic signaling in multiple myeloma and lymphoma. Insights from his research are helping to identify novel therapeutic targets and to exploit druggable pathways in lymphoid malignancies.

Areas of Expertise


Selected Publications

IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

Arnold Bolomsky, Michele Ceribelli, Sebastian Scheich, Kristina Rinaldi, Da Wei Huang, Papiya Chakraborty, Lisette Pham, George W. Wright, Tony Hsiao, Vivian Morris, Jaewoo Choi, James D. Phelan, Ronald J. Holewinski, Thorkell Andresson, Jan Wisniewski, Deanna Riley, Stefania Pittaluga, Elizabeth Hill, Craig J. Thomas, Jagan Muppidi, and Ryan M. Young
Cancer Cell. 2024.
Full-Text Article
[ Journal Article ]

Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma

Yandan Yang, Arnold Bolomsky, Thomas Oellerich, Ping Chen, Michele Ceribelli, Björn Häupl, George W Wright, James D Phelan, Da Wei Huang, James W Lord, Callie K Van Winkle, Xin Yu, Jan Wisniewski, James Q Wang, Frances A Tosto, Erin Beck, Kelli Wilson, Crystal McKnight, Jameson Travers, Carleen Klumpp-Thomas, Grace A Smith, Stefania Pittaluga, Irina Maric, Dickran Kazandjian, Craig J Thomas, Ryan M Young
nature communications. 13 (1): 5469, 2022.
Full-Text Article
[ Journal Article ]

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.
Nature. 560(7718): 387-91, 2018. [ Journal Article ]

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens

Young RM, Wu T, Schmitz R, Dawood M, Xiao W, Phelan JD, Xu W, Menard L, Meffre E, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Staudt LM.
Proc Natl Acad Sci U S A. 112(44): 13447-54, 2015. [ Journal Article ]

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Research Fellow
Arnold Bolomsky, Ph.D.
Kristina Rinaldi


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