Ryan M. Young, Ph.D.

Ryan M. Young, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Lymphoid Malignancies Branch


Dr. Young employs proteogenomic technologies to elucidate novel modes of pathogenic signaling in multiple myeloma and lymphoma. Insights from his research are helping to identify novel therapeutic targets and to exploit druggable pathways in lymphoid malignancies.

Areas of Expertise


Selected Key Publications

Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14

Choi J, Phelan JD, Wright GW, Häupl B, Huang DW, Shaffer AL 3rd, Young RM, Wang Z, Zhao H, Yu X, Oellerich T, Staudt LM.
Proc Natl Acad Sci U S A. 117(11): 6092-6102, 2020. [ Journal Article ]

Pathogenic B-cell receptor signaling in lymphoid malignancies: New insights to improve treatment

Young RM, Phelan JD, Wilson WH, Staudt LM.
Immunol Rev. 291(1): 190-213, 2019. [ Journal Article ]

TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib

Dadashian EL, McAuley EM, Liu D, Shaffer AL 3rd, Young RM, Iyer JR, Kruhlak MJ, Staudt LM, Wiestner A, Herman SEM.
Cancer Res. 79(2): 360-71, 2019. [ Journal Article ]

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.
Nature. 560(7718): 387-91, 2018. [ Journal Article ]

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens

Young RM, Wu T, Schmitz R, Dawood M, Xiao W, Phelan JD, Xu W, Menard L, Meffre E, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Staudt LM.
Proc Natl Acad Sci U S A. 112(44): 13447-54, 2015. [ Journal Article ]

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Scientist (Contr.)
Ping Chen, Ph.D.
Postbaccalaureate Fellow (CRTA)
Callie Van Winkle, B.S.


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