Breadcrumb

Mark B. Lewandoski, Ph.D.

Mark B. Lewandoski, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Head, Genetics of Vertebrate Development Section

RESEARCH SUMMARY

Dr. Lewandoski has made seminal contributions to the development of the Cre/loxP system for the conditional control of gene expression in mice. He has applied these approaches and other aspects of mouse genetics to an analysis of embryonic development, in particular, limb development, somitogenesis, and axis extension. In this work he focuses on Fibroblast Growth Factor (FGF) signaling, which controls most aspects of cellular behavior, including apoptosis, differentiation, gene regulation and programmed cell death. He also investigates how the embryo integrates FGF signals with other pathways, notably that of WNT and BMP signaling.

Areas of Expertise

Fibroblast Growth Factor (FGF) Signaling
Cre/loxP Recombination
Somitogenesis
Embryonic and Limb Development

Publications

Selected Key Publications

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function

Matthew J Anderson, Valentin Magidson, Ryoichiro Kageyama, Mark Lewandoski
Elife. 9: e55608, 2020.
Full-Text Article
[ Journal Article ]

Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb

Irene Delgado, Alejandra C López-Delgado, Alberto Roselló-Díez, Giovanna Giovinazzo , Vanessa Cadenas , Laura Fernández-de-Manuel, Fátima Sánchez-Cabo, Matthew J Anderson , Mark Lewandoski , Miguel Torres
Sci. Adv.. 6(23): eaaz0742, 2020.
Full-Text Article
[ Journal Article ]

The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall

Michael Boylan , Matthew J Anderson , David M Ornitz , Mark Lewandoski
Development. 147 (21): dev189506, 2020.
Full-Text Article
[ Journal Article ]

An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension

Matthew J. Anderson, Thomas Schimmang, Mark Lewandoski
PLoS Genet.. 12 (5): e1006018, 2016.
Full-Text Article
[ Journal Article ]

BMPs are direct triggers of interdigital programmed cell death

Kaltcheva MM, Anderson MJ, Harfe BD, Lewandoski M.
Dev Biol.. 411(2): 266-276, 2016.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Team

Dr. Qingyuan Fan
Biologist
Qingyuan (James) Fan, M.D., Ph.D.
Erika Truffer
Animal Technician
Erika L. Truffer
Anne-Cecile Choutedjem
POSTBACCALAUREATE FELLOW
Anne-Cecile Evelyne Choutedjem Kamgue Nkamougna, B.S.
Postbaccalaureate Fellow
Natalie Daigle, B.S.

News

Mark Lewandoski, Ph.D. and Taylor Pompan, B.S. (NSF Awardee)
April 2024 - Pictured: Mark Lewandoski, Ph.D. and Taylor Pompan, B.S.  Lewandoski Lab congratulates member Taylor Pompan, recipient of the National Science Foundation (NSF) Graduate Fellowship Program (GRFP)

Alumni

Taylor Pompan, B.S., Postbaccalaureate Fellow, Lewandoski Lab, CDBL
Taylor Pompan, B.S.
July 2022 - July 2024
Luke Ostendorf-Snell
Luke Ostendorf-Snell
June 2022 - July 2023, May 2024 - July 2024
Current Position: Student pursuing a Bioengineering degree at the University of Maryland
Joanne Unite, B.S.
Joanne Unite, B.S.
September 2020 - July 2022
Current Position: Research Associate Frederick National Lab, Leidos
Sarah Martin
Sarah Martin
June 2021 - August 2021
Cynthia Elder
Cynthia Elder
December 2008 - February 2021
Current Position: Retired
Patricia Abete-Luzi, Ph.D.
Patricia Abete-Luzi, Ph.D.
November 2019 - April 2021
Salvia Misaghian, M.S.
Salvia Misaghian, M.S.
July 2017 - June 2019, July 2019 - July 2023
Current Position: Ph.D. Student, George Mason University, VA
Christian Bonatto Paese, Ph.D.
Christian Bonatto Paese, Ph.D.
October 2018 - October 2019
Thilinie Kuruppu, B.S.
Thilinie Kuruppu, B.S.
June 2017 - August 2018, July 2019 - August 2019
Current Position: B.S. Bioengineering, Univ. Maryland. Injection Molding Process Engineer, Becton Dickson, Inc.
McCauley Brown
McCauley Brown
July 2017 - July 2018, May 2019 - July 2019
Trevor Ellis
Trevor Ellis
August 2018 - June 2019
Sumi Mondal
Sumi Mondal
June 2017 - July 2018
Maria Kaltcheva, Ph.D.
Maria Kaltcheva, Ph.D.
September 2015 - September 2017
Current Position: Toxicologist, Federal Food and Drug Administration (FDA)
Aaron Raju
Aaron Raju
May 2016 - July 2016
Current Position: MS Program Student, University of Alabama at Birmingham, School of Public Health
Irene Hung, M.D.
Irene Hung, M.D.
July 2011 - March 2016
Current Position: Clinical Geneticist, Hackensack University Med. Group, Clin. Genetics and Genomics, NJ
Catherine Wilson
Catherine Wilson
September 2001 - February 2007
Current Position: Histology Lab Supervisor, Proean BioDiagnostics, Inc., FL
Naiche Adler, Ph.D.
Naiche Adler, Ph.D.
February 2008 - February 2014
Current Position: Scientific Director, University of Illinois at Chicago
Samuel Waters, Ph.D.
Samuel Waters, Ph.D.
April 2001 - August 2006
Current Position: Assistant Professor, University of the District of Columbia
Vera Veronina, Ph.D.
Vera Veronina, Ph.D.
Current Position: Associate Director, Regeneron Pharmaceuticals, Inc., NY
Nakisha Holder, Ph.D.
Nakisha Holder, Ph.D.
October 2003 - November 2007
Current Position: Associate Director, Johns Hopkins Technology Ventures, JHU, MD
Sangeeta Underwood, Ph.D.
Sangeeta Underwood, Ph.D.
August 2002 - August 2009
Current Position: Bioengineer, Dept. of Defense
Charmaine Richman, Ph.D.
Charmaine Richman, Ph.D.
Current Position: Scientific Project Manager, Booz Allen Hamilton, Inc., WV