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Mark B. Lewandoski, Ph.D.

Mark B. Lewandoski, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Lewandoski has made seminal contributions to the development of the Cre/loxP system for the conditional control of gene expression in mice. He has applied these approaches and other aspects of mouse genetics to an analysis of embryonic development, in particular, limb development, somitogenesis, and axis extension. In this work he focuses on Fibroblast Growth Factor (FGF) signaling, which controls most aspects of cellular behavior, including apoptosis, differentiation, gene regulation and programmed cell death. He also investigates how the embryo integrates FGF signals with other pathways, notably that of WNT and BMP signaling.

Areas of Expertise

Fibroblast Growth Factor (FGF) Signaling
Cre/loxP Recombination
Somitogenesis
Embryonic and Limb Development

Publications

Selected Key Publications

Fgf4 maintains Hes7 levels critical for normal somite segmentation clock function

Matthew J Anderson, Valentin Magidson, Ryoichiro Kageyama, Mark Lewandoski
Elife. 9: e55608, 2020.
Full-Text Article
[ Journal Article ]

Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb

Irene Delgado, Alejandra C López-Delgado, Alberto Roselló-Díez, Giovanna Giovinazzo , Vanessa Cadenas , Laura Fernández-de-Manuel, Fátima Sánchez-Cabo, Matthew J Anderson , Mark Lewandoski , Miguel Torres
Sci. Adv.. 6(23): eaaz0742, 2020.
Full-Text Article
[ Journal Article ]

The Fgf8 subfamily (Fgf8, Fgf17 and Fgf18) is required for closure of the embryonic ventral body wall

Michael Boylan , Matthew J Anderson , David M Ornitz , Mark Lewandoski
Development. 147 (21): dev189506, 2020.
Full-Text Article
[ Journal Article ]

An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension

Matthew J. Anderson, Thomas Schimmang, Mark Lewandoski
PLoS Genet.. 12 (5): e1006018, 2016.
Full-Text Article
[ Journal Article ]

BMPs are direct triggers of interdigital programmed cell death

Kaltcheva MM, Anderson MJ, Harfe BD, Lewandoski M.
Dev Biol. 411(2): 266-76, 2016. [ Journal Article ]

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