Matthew J. Anderson, Ph.D.

Matthew J. Anderson, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Anderson uses complex mouse genetics and advanced imaging analysis to elucidate the signaling requirements for embryonic axis and limb development, with a focus on FGF signaling. Understanding how these pathways signal during development often informs us how they signal in various diseases, including cancer. An example of this work is Dr. Anderson’s identification of a novel signaling requirement for Fgf3 to limit BMP signaling in the forming neural tube. When the gene encoding Fgf3 is inactivated, mice develop neural tube and posterior axis defects, because of increased BMP signaling within the dorsal neural tube and axial progenitor tissue. Neural tube defects are exacerbated when BMP signaling is genetically increased, and in some cases leads to spina bifida and spina bifida occulta, a common human congenital malformation. 

Areas of Expertise

FGF Signaling
Mouse Genetics
Genome Manipulation


Selected Recent Publications

An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension

Anderson MJ, Schimmang T, Lewandoski M.
PLoS Genet. 12(5): e1006018, 2016. [ Journal Article ]

Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development

Anderson MJ, Southon E, Tessarollo L, and Lewandoski M.
Genesis. 54(2): 91-98, 2016. [ Journal Article ]

BMPs are direct triggers of interdigital programmed cell death

Kaltcheva MM, Anderson MJ, Harfe BD, and Lewandoski M.
Dev Biol. 411(2): 266-276, 2016. [ Journal Article ]

FGF-Regulated Etv Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching

Herriges J, Zhang Z, Zhang Y, Anderson MJ, Swing DA, Lewandoski M, and Sun X.
Dev Cell. 35(3): 322-332, 2015. [ Journal Article ]

TCreERT2, a transgenic mouse line for temporal control of Cre-mediated recombination in lineages emerging from the primitive streak or tail bud

Anderson MJ, Naiche LA, Elder C, Wilson C, Swing D, Lewandoski M.
PLoS One. 8(4): e62479, 2013. [ Journal Article ]