Steven Cappell

Steven D. Cappell, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Cappell focuses on understanding the cellular and molecular mechanisms underlying cell cycle regulation at the single-cell level. In particular, he applies state-of-the-art live-cell imaging approaches and fluorescent biosensors to dissect the dynamic signaling pathways controlling the G1 to S phase transition. His work has shed new light on how cells make the decision to proliferate and the origin of cell-to-cell heterogeneity.

Areas of Expertise


Selected Key Publications

Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation

Afifi MM, Crncec A, Cornwell JA, Cataisson C, Paul D, Ghorab LM, Hernandez MO, Wong M, Kedei N, Cappell SD
Cell Reports. 42: 113079, 2023.
Full-Text Article
[ Journal Article ]

Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal

Cornwell JA, Crncec A, Afifi MA, Tang K, Amin R, Cappell SD
Nature. 2023.
Full-Text Article
[ Journal Article ]

Revealing beta-TrCP activity dynamics in live cells with a genetically encoded biosensor

Paul D, Kales SC, Cornwell JA, Afifi MM, Rai G, Zakharov A, Simeonov A, Cappell SD.
Nat Commun. 13: 2022.
Full-Text Article
[ Journal Article ]

Cell cycle inertia underlies a bifurcation in cell fates after DNA damage

Nathans JF*, Cornwell JA*, Afifi MM, Paul D, Cappell SD
Science Advances. 7: 2021.
Full-Text Article
[ Journal Article ]

EMI1 switches from being a substrate to an inhibitor of APC/C-CDH1 to start the cell cycle

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T
Nature. 558/7709: 313-317, 2018.
Full-Text Article
[ Journal Article ]

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The American Association for Dental, Oral and Craniofacial Research (AAODCR) offers the Hatton Award based on an oral presentation competition held at the AADOCR Annual Meeting & Exhibition. The competition is designed for junior investigators (junior, senior and post-doctoral) who exhibit potential for a productive career in dental research. Marwa won first place in the postdoctoral category, a highly competitive category. Congratulations, Marwa!