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Steven D. Cappell, Ph.D.

Steven D. Cappell, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Cappell focuses on understanding the cellular and molecular mechanisms underlying cell cycle regulation at the single-cell level. In particular, he applies state-of-the-art live-cell imaging approaches and fluorescent biosensors to dissect the dynamic signaling pathways controlling the G1 to S phase transition. His work has shed new light on how cells make the decision to proliferate and the origin of cell-to-cell heterogeneity.

Areas of Expertise

1) signal transduction 2) systems biology 3) cell cycle 4) single-cell analysis 5) fluorescent biosensors 6) ubiquitin ligases

Publications

Selected Key Publications

Cell cycle inertia underlies a bifurcation in cell fates after DNA damage

Jenny F. Nathans*, James A. Cornwell*, Marwa M. Afifi, Debasish Paul, Steven D. Cappell
Science Advances. 7: 2021.
Full-Text Article
[ Journal Article ]

EMI1 switches from being a substrate to an inhibitor of APC/C-CDH1 to start the cell cycle

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T
Nature. 558/7709: 313-317, 2018.
Full-Text Article
[ Journal Article ]

Irreversible APC(Cdh1) inactivation underlies the point of no return for cell-cycle entry

Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T.
Cell. 166: 167-180, 2016.
Full-Text Article
[ Journal Article ]

Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation

Yang HW, Cappell SD, Jaimovich A, Liu C, Chung M, Daigh LH, Pack LR, Fan Y, Regot S, Covert M, Meyer T
eLife. 2020.
Full-Text Article
[ Journal Article ]

Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1

Chung M, Liu C, Yang HW, Köberlin MS, Cappell SD, Meyer T.
Mol Cell. 2019.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Team

Postdoctoral Fellow (Visiting)
Marwa Afifi, Ph.D., B.D.
Postdoctoral Fellow (Visiting)
James Cornwell, Ph.D.
Postdoctoral Fellow (Visiting)
Debasish Paul, Ph.D.
Postdoctoral Fellow (Visiting)
Adrijana Crncec, Ph.D.
Postbaccalaureate Fellow (CRTA)
Kevin Tang, B.S.