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Steven D. Cappell, Ph.D.

Steven D. Cappell, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Cappell focuses on understanding the cellular and molecular mechanisms underlying cell cycle regulation at the single-cell level. In particular, he applies state-of-the-art live-cell imaging approaches and fluorescent biosensors to dissect the dynamic signaling pathways controlling the G1 to S phase transition. His work has shed new light on how cells make the decision to proliferate and the origin of cell-to-cell heterogeneity.

Areas of Expertise

1) signal transduction 2) systems biology 3) cell cycle 4) single-cell analysis 5) fluorescent biosensors 6) ubiquitin ligases

Publications

Selected Key Publications

Revealing beta-TrCP activity dynamics in live cells with a genetically encoded biosensor

Paul D, Kales SC, Cornwell JA, Afifi MM, Rai G, Zakharov A, Simeonov A, Cappell SD.
Nat Commun. 13: 2022.
Full-Text Article
[ Journal Article ]

Cell cycle inertia underlies a bifurcation in cell fates after DNA damage

Nathans JF*, Cornwell JA*, Afifi MM, Paul D, Cappell SD
Science Advances. 7: 2021.
Full-Text Article
[ Journal Article ]

EMI1 switches from being a substrate to an inhibitor of APC/C-CDH1 to start the cell cycle

Cappell SD, Mark KG, Garbett D, Pack LR, Rape M, Meyer T
Nature. 558/7709: 313-317, 2018.
Full-Text Article
[ Journal Article ]

Irreversible APC(Cdh1) inactivation underlies the point of no return for cell-cycle entry

Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T.
Cell. 166: 167-180, 2016.
Full-Text Article
[ Journal Article ]

Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation

Yang HW, Cappell SD, Jaimovich A, Liu C, Chung M, Daigh LH, Pack LR, Fan Y, Regot S, Covert M, Meyer T
eLife. 2020.
Full-Text Article
[ Journal Article ]

Job Vacancies

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