Marielle E. Yohe, M.D., Ph.D.

Marielle E. Yohe, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Advanced Technology Research Facility, Room D3026
  • Frederick, MD 21701
  • 240-760-7436
Laboratory of Cell and Developmental Signaling


Dr. Yohe is a physician-scientist whose lab studies the role of aberrant small GTPase signaling in the development of pediatric solid tumors, such as rhabdomyosarcoma and neuroblastoma, and the RASopathies, such as Costello syndrome and cardiofaciocutaneous syndrome, using a combination of biochemical, epigenetic, cellular and model organism approaches.  She is actively engaged in clinical trials through the NCI and the Children’s Oncology Group to investigate the safety and efficacy of RAS/MAPK-targeting agents in pediatric patients.

Areas of Expertise


Selected Key Publications

Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies

Gross AM, Frone M, Gripp KW, Gelb BD, Schoyer L, Schill L, Stronach B, Biesecker LG, Esposito D, Hernandez ER, Legius E, Loh ML, Martin S, Morrison DK, Rauen KA, Wolters PL, Zand D, McCormick F, Savage SA, Stewart DR, Widemann BC, Yohe ME.
Am J Med Genet A. 182(4): 866-876, 2020. [ Journal Article ]

Rigosertib induces mitotic arrest and apoptosis in RAS-driven rhabdomyosarcoma and neuroblastoma

Kowalczyk JT, Wan X, Hernandez ER, Luo R, Lyons GC, Wilson KM, Gallardo DC, Isanogle KA, Robinson CM, Mendoza A, Heske CM, Chen J-Q, Luo X, Kelly AE, Difilippantonio S, Robey RW, Thomas CJ, Sackett DL, Morrison DK, Randazzo PA, Miller Jenkins LM, Yohe ME
Molecular Cancer Therapeutics . DOI: 10.1158/1535-7163.MCT-20-0525, 2020. [ Journal Article ]

MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma

Yohe ME, Gryder BE, Shern JF, Song YK, Chou, H-C, Sindiri S, Mendoza A, Patidar R, Zhang X, Guha R, Butcher D, Isanogle KA, Robinson CM, Luo X, Chen J-Q, Walton A, Awasthi P, Edmondson EF, Difilippantonio S, Wei JS, Zhao K, Ferrer M, Thomas CJ, Khan J
Science Translational Medicine. 10: 448, 2018. [ Journal Article ]

PAX3-FOXO1 establishes myogenic super enhancers and confers BET bromodomain vulnerability

Gryder BE, Yohe ME, Chou H-C, Zhang X, Song Y, Marques J, Schaefer B, Sen N, Patidar R, Wen X, Wei J, Guha R, Ferrer M, Lal-Nag M, Andresson T, Shern JF, Zhao K, Thomas CJ, and Khan J.
Cancer Discovery. 7: 884-899, 2017. [ Journal Article ]

Pediatric Rhabdomyosarcoma

Shern JF, Yohe ME and Khan J.
Critical Reviews in Oncogenesis. 20: 227-243, 2015. [ Journal Article ]

Job Vacancies

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Postdoctoral Fellow (CRTA)
Katie E. Hebron, Ph.D.
Visiting Fellow
Subhra Dash, Ph.D.
Stacey Stauffer
Predoctoral Fellow
Ashwaq Aljabri
Postbac Fellow
Lucas Stauffer