Breadcrumb

John Brognard, Ph.D.

John Brognard, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

My lab studies cancer-associated kinases in the unexplored kinome, using bioinformatics and functional genomic approaches, to understand the molecular mechanisms by which these kinases promote tumorigenesis. With in vivo patient-derived xenograft (PDX) mouse models, we will translate these findings to the clinic by developing novel compounds, such as PROTACs (proteolysis targeting chimeras), or by repurposing existing drugs to target these kinase drivers of cancer. The goal is to provide a platform for transformational research to identify novel druggable drivers to benefit cancer patients without durable treatment options.

Areas of Expertise

1) cancer cell signaling 2) tumor suppressors 3) oncogenes 4) cancer genetics 5) lung and head and neck cancers 6) kinases

Publications

Selected Recent Publications

TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin

Pedro Torres-Ayuso, Elvira An , Katherine M Nyswaner , Ryan C Bensen, Daniel A Ritt, Suzanne I Specht , Sudipto Das, Thorkell Andresson, Raul E Cachau, Roger J Liang, Amy L Ries, Christina M Robinson , Simone Difilippantonio, Brad Gouker, Laura Bassel, Baktiar O Karim, Chad J Miller, Benjamin E Turk , Deborah K Morrison, John Brognard
Cancer Discov.. Jan. 25: Online ahead of print, 2021. [ Journal Article ]

The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells

Hoang VT, Nyswaner K, Torres-Ayuso P, Brognard J.
J Biol Chem. Jun 19 295(25): 8470-8479, 2020. [ Journal Article ]

Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases

Hudson AM, Stephenson NL, Li C, Trotter E, Fletcher AJ, Katona G, Bieniasz- Krzywiec P, Howell M, Wirth C, Furney S, Miller CJ, Brognard J.
Sci Signal. 11(526): eaan6776, 2018. [ Journal Article ]

Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53

Edwards ZC, Trotter EW, Torres-Ayuso P, Chapman P, Wood HM, Nyswaner K, Brognard J.
Cancer Res. 77(18): 4961-4972, 2017. [ Journal Article ]

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J*, Newton AC*. *Corresponding authors
Cell. 160(3): 489-502, 2015. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postdoctoral Fellow (CRTA)
Ryan Bensen, Ph.D.
Postbaccalaureate Fellow (CRTA)
Knicki Bergman, B.S.
Postdoctoral Fellow (CRTA)
Amy Funk, Ph.D.
Postbaccalaureate Fellow (CRTA)
Sophia Lookingbill, B.S.
Research Biologist
Katherine Nyswaner, MSc.
Postdoctoral Fellow (Visiting)
Pedro Torres-Ayuso, Ph.D.
Postdoctoral Fellow (Visiting)
Meghri Katerji, Ph.D.
Postdoctoral Fellow (Visiting)
Jungwuk Lee, Ph.D.
Visiting Fellow
Dawid Mehlich, BSC