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Mardo Kõivomägi

Mardo Kõivomägi, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Mardo Kõivomägi is a biochemist studying the biochemical mechanisms cyclin-dependent kinase complexes used to control cell division and how to target these mechanisms with novel therapeutics against cancer. He takes an interdisciplinary approach combining quantitative methods in biochemistry, genetics, imaging, phosphoproteomics and systems biology.

Areas of Expertise

Cyclin-Cdk-Cks Biochemistry
Kinase-Substrate Docking
G1/S Control
Gene Expression
Cell-Cycle Regulation

Publications

Selected Key Publications

G1 cyclin-Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II

Kõivomägi M, Swaffer MP, Turner JJ, Marinov G, Skotheim JM.
Science. 374(6565): 347-351, 2021. [ Journal Article ]

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix

Topacio BR, Zatulovskiy E, Cristea S, Xie S, Tambo CS, Rubin SM, Sage J, Kõivomägi M, Skotheim JM.
Mol Cell. 74(4): 758-770.e4, 2019. [ Journal Article ]

Multisite phosphorylation networks as signal processors for Cdk1

Kõivomägi M, Ord M, Iofik A, Valk E, Venta R, Faustova I, Kivi R, Balog ER, Rubin SM, Loog M.
Nat Struct Mol Biol. 20(12): 1415-24, 2013. [ Journal Article ]

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ER, Rubin SM, Morgan DO, Loog M.
Nature. 480(7375): 128-31, 21993622. [ Journal Article ]

Dynamics of Cdk1 substrate specificity during the cell cycle

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan DO, Loog M.
Mol Cell. 42(5): 610-23, 2011. [ Journal Article ]

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